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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/2718

Title: Persistent overexpression of SERCA2a affects bladder functions under physiological conditions, but not in bladder outlet obstruction-induced sub-acute pathological conditions.
Other Titles: SERCA2aの持続的過剰発現は、生理的条件下では膀胱機能に影響を及ぼすが、膀胱出口部閉塞亜急性期の病的条件下では膀胱機能に影響しない
Authors: Yamada, Atsushi
Torimoto, Kazumasa
Obata, Koji
Hirayama, Akihide
Fujimoto, Kiyohide
Takaki, Miyako
Keywords: Rat bladder
SERCA2 overexpression
Outlet obstruction
Issue Date: Jan-2014
Publisher: Physiological Society of Japan / Springer Japan
Citation: The journal of physiological science Vol.64 No.1 p.21-30
Abstract: A functional impairment of the bladder and heart in a decompensated state caused by a pressure overload is accompanied by a decrease in the sarcoplasmic reticulum Ca2+-ATPase (SERCA2). The beneficial effects of SERCA2 overexpression in preserving cardiac functions have been previously reported. The aim of the present study was to investigate the effects of overexpressed SERCA2 on bladder functions under physiological and pathological conditions using partial bladder outlet obstruction (BOO) in SERCA2a transgenic Wistar rats (TG). Bladder cystometry and western blot analysis were performed using the wild-type Wistar rats (WT), TG, and BOO models (WTBOO and TGBOO). Persistent overexpression of SERCA2 induces reduced bladder compliance without hypertrophy in TG. BOO induces reduced bladder compliance and hypertrophy in WT and TG in the sub-acute phase, but persistent overexpression of SERCA2a in TG does not aggravate the bladder compliance and hypertrophy. In conclusion, SERCA2a overexpression affects bladder functions under physiological conditions, but not in BOO-induced sub-acute pathological conditions.
Description: 博士(医学)・甲第623号・平成26年5月28日
URI: http://hdl.handle.net/10564/2718
ISSN: 18806546
Academic Degrees and number: 24601A623
Degree-granting date: 2014-05-28
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2014年度

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