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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/2715

Title: Structure of vitreous body and its relationship with liquefaction.
Other Titles: 硝子体の構造とその液化との関係
Authors: Kodama, Makoto
Matsuura, Toyoaki
Hara, Yoshiaki
Keywords: Vitreous Body
Liquefaction
Crystallin
Issue Date: Jul-2013
Publisher: Scientific Research Pub.
Citation: Journal of biomedical science and engineering Vol.6 No.7 p.739-745
Abstract: The aim of the study is to clarify the vitreous body structure and liquefaction phenomena. It was found that when melting a frozen rabbit vitreous body, the gel-sol transition phenomenon occurs and the gel structure is broken. This is almost like the liquefaction of the vitreous body in vivo. We try to clarify the liquefaction phenomenon by using this animal model. The native vitreous body has three dimensional meshwork structures. After liquefaction, it is changed into two parts, namely fiber aggregates and soluble amorphous aggregates. The surface of native vitreous body meshwork is mucopolysacharide, but that of fiber aggregates after liquefaction is changed into connective tissue, which means the conformational change of vitreous body in liquefaction. The soluble proteins after liquefaction were analyzed and identified as crystallin family. It is suggested that the liquefaction is induced by detachment of non-collagenous protein beads containing crystallins, resulting in the collapse of the three dimensional structure to release watery liquid trapped within. And the new gel-sol transition model of vitreous bod is proposed.
Description: 博士(医学)・乙1330号・平成26年3月17日
URI: http://hdl.handle.net/10564/2715
ISSN: 19376871
Academic Degrees and number: 24601B1330
Degree-granting date: 2014-03-17
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2013年度

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