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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/2708

Title: Intranasal priming of newborn mice with microbial extracts increases opsonic factors and mature CD11c+ cells in the airway.
Other Titles: 新生児マウス鼻腔への微生物抽出液の投与は気道中のオプソニン量及び、成熟CD1c+ 細胞を増加させる
Authors: Kasahara, Kazuki
Matsumura, Yoko
Ui, Kouji
Kasahara, Kei
Komatsu, Yuko
Mikasa, Keiichi
Kita, Eiji
Keywords: commensal flora
regulation of acute inflammation
Issue Date: 1-Nov-2012
Publisher: American Physiological Society
Citation: American journal of physiology. Lung cellular and molecular physiology Vol.303 No.9 p.L834-843
Abstract: Nasal exposure to the mixture of microbial extracts (MME) after ablactation enhanced airway resistance of newborn mice to Streptococcus pneumoniae (J Physiol Lung Cell Mol Physiol 298: L67, 2010). The present study was addressed to elucidate effective factors responsible for the enhanced innate resistance in the airway of MME-exposed newborn mice. MME exposure significantly increased the amount of pulmonary surfactants (SP-A and SP-D) in the airway. Bronchoalveolar lavage fluid of the exposed mice exhibited greater levels of opsonic activity, thereby enhancing the phagocytic and intracellular killing activities of alveolar macrophages (MØ) against S. pneumoniae. The exposure itself did not increase a complement component C3 and mannan-binding lectin-A (MBL-A) in the airway, whereas intratracheal infection with S. pneumoniae increased the quantity of SP-A, SP-D, C3, and MBL-A in the exposed mice to a significant extent compared with control mice. The exposure enhanced the expression of the class A scavenger MØ receptor with collagenous structure on alveolar MØ and also increased the frequency of major histocompatibility complex II+ CD11c+ cells in the lung; the cells were able to produce IL-10 and transforming growth factor-β in vitro. These results suggest that microbial exposure early in life increases the amounts of SP-A and SP-D and the number of scavenger MØ and also promotes maturation of CD11c+ cells in the airway of newborn mice, which may be involved in airway resistance to S. pneumoniae.
Description: 博士(医学)・乙1323号・平成26年3月17日
発行元の規定により、本文の登録不可。本文は以下のURLを参照 "http://dx.doi.org/10.1152/ajplung.00031.2012"
URI: http://hdl.handle.net/10564/2708
ISSN: 10400605
Academic Degrees and number: 24601B1323
Degree-granting date: 2014-03-17
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2013年度

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