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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/2695

Title: Abnormal distribution of aquaporin-5 and lymphoid infiltration in salivary glands of primary sjögren's syndrome.
Other Titles: 原発性シェーグレン症候群の唾液腺におけるリンパ球浸潤とアクアポリン5の分布異常について
Authors: Kobayashi, Takehiko
Fujimoto, Takashi
Yane, Katsunari
Hosoi, Hiroshi
Keywords: aquaporin-5
salivary gland
Sjögren's syndrome
Issue Date: 30-Nov-2013
Publisher: 奈良医学会
Citation: Journal of Nara Medical Association Vol.64 No.4 p.65-72
Abstract: Objectives: Patients with Sjögren's syndrome (SS) suffer from impaired saliva secretion due to an autoimmune destruction of salivary glands. Based upon its abnormal distribution in SS salivary glands, a potential role for the water channel protein aquaporin-5 (AQP5) is proposed in the pathogenesis of SS. Methods: The immunohistochemical distribution of AQP5 was compared in minor salivary gland (MSG) biopsies obtained from primary SS with a variety of lymphoid cells infiltration in MSG, and healthy volunteers. Results: Biopsies from normal subjects revealed AQP5 primarily at the apical membrane of the salivary gland acinus. In contrast, biopsies from SS patients with both moderate and severe lymphoid infiltration revealed AQP5 expression diffusely at the cytoplasm of the acinus. Computer-assisted microscopy was performed to quantitatively evaluate AQP5 distribution in the acini. Biopsies of SS patients exhibited lower labeling indices (LI) at the apical membrane compared with biopsies from control subjects. The LI of the acini obtained from SS patients with both moderate and severe lymphoid infiltration showed no difference. Conclusions: Abnormal distribution of AQP5 in salivary gland acini could be responsible for a loss of saliva secretion, and this abnormal distribution is likely to develop during the stage of moderate lymphoid infiltration in salivary gland.
Description: 博士(医学)・乙1334号・平成26年3月17日
URI: http://hdl.handle.net/10564/2695
ISSN: 13450069
Academic Degrees and number: 24601B1334
Degree-granting date: 2014-03-17
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2013年度
Vol.64 No.4

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