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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/2674

Title: Involvement of autoimmunity to REG, a regeneration factor, in patients with primary Sjögren's syndrome
Other Titles: 原発性シェーグレン症候群患者における再生因子REG(regenerating gene)に対する自己免疫の関与
Authors: Yoshimoto, Kiyomi
Fujimoto, Takashi
Itaya-Hironaka, Asako
Miyaoka, Tomoko
Sakuramoto-Tsuchida, Sumiyo
Yamauchi, Akiyo
Takeda, Maiko
Kasai, Takahiko
Nakagawara, Kan-ichi
Nonomura, Akitaka
Takasawa, Shin
Keywords: REG family genes
REG Iα protein
anti-REG Iα autoantibodies
Sjögren’s syndrome
ductal epithelial cells
Issue Date: Oct-2013
Publisher: Blackwell Scientific Pub.
Citation: Clinical and experimental immunology Vol.174 No.1 p.1-9
Abstract: The regenerating gene (Reg) was isolated originally as a gene specifically over-expressed in regenerating pancreatic islets and constitute a growth factor family. Reg gene product (Reg) is important in the pathophysiology of various human inflammatory diseases. Recently, the possible involvement of human REG in the regeneration of salivary ductal epithelial cells of patients with primary Sjögren's syndrome (SS) was reported. However, the expression of the REG family genes in minor salivary glands (MSG) and the occurrence of anti-REG Iα autoantibodies in SS patients were obscured. In this study, we examined the expression of REG family genes in the MSG of SS and screened anti-REG Iα autoantibodies in SS. The mRNA levels of REG family genes in MSG were quantified using real-time reverse transcription-polymerase chain reaction (RT-PCR) and REG Iα expression in the MSG was analysed by immunohistochemistry. The mRNA level of REG Iα in the MSG of SS patients was significantly higher than that of control. REG Iα protein was expressed highly in SS ductal epithelial cells. Anti-REG Iα autoantibodies in the sera were found in 11% of SS. All the MSG in the anti-REG Iα autoantibody-positive group showed REG Iα expression, whereas only 40% showed REG Iα expression in the anti-REG Iα autoantibody-negative group. The anti-REG Iα autoantibody-positive group showed significantly lower saliva secretion and a higher ratio of grade 4 (by Rubin-Holt) in sialography. These data suggest strongly that autoimmunity to REG Iα might play a role in the degeneration of MSG ductal epithelial cells in primary SS.
Description: 博士(医学)・乙第1319号・平成25年11月27日
The definitive version is available at " http://dx.doi.org/10.1111/cei.12142 "
URI: http://hdl.handle.net/10564/2674
ISSN: 00099104
Academic Degrees and number: 24601B1319
Degree-granting date: 2013-11-27
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2013年度

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