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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/2670

Title: Protumoral roles of melanoma inhibitory activity 2 in oral squamous cell carcinoma
Other Titles: 口腔扁平上皮癌におけるmelanoma inhibitory activity 2 (MIA2)の腫瘍促進性
Authors: Kurihara, Miyako
Kirita, Tadaaki
Sasahira, Tomonori
Ohmori, Hitoshi
Matsushima, Sayako
Yamamoto, Kazuhiko
Bosserhoff, Anja Katrin
Kuniyasu, Hiroki
Keywords: apoptosis
VEGF
integrin
MAPK
Issue Date: 16-Apr-2013
Publisher: Nature Publishing
Citation: British journal of cancer Vol.108 No.7 p.1460-1469
Abstract: The role of melanoma inhibitory activity 2 (MIA2) was examined in human oral squamous cell carcinoma (OSCC). MIA2 expression was observed in 62 (66.7%) of 93 OSCCs and was associated with tumor expansion and nodal metastasis. MIA2 expression was inversely correlated with intratumoral infiltration of lymphocytes. MIA2 expression was found in 3 human OSCC lines. Invasion and anti-apoptotic survival were reduced by MIA2 knockdown in HSC3 cells. The number of MOLT-3 lymphocytes infiltrating the HSC3 cell layer was increased by MIA2 knockdown or MIA2 depletion by MIA2 knockdown and absorption with the antibody. In HSC3 cells, MIA2 knockdown decreased the expressions of vascular endothelial growth factor (VEGF), VEGF-C, VEGF-D. The downregulation of VEGF-C and -D was caused by inhibition of p38 and extracellular signal-regulated kinase (ERK)1/2, respectively. MIA2 was coprecipitated with integrin α4 andα5 in HSC3 cells. Integrin α4 knockdown decreased p38 phosphorylation and increased apoptosis, whereas integrin α5 knockdown decreased c-Jun N-terminal kinase (JNK) phosphorylation and apoptosis. Inhibition of JNK decreased apoptosis in the HSC3 cells. These findings suggest that the roles of MIA2 might be based on the variety of the integrins and the subtypes of mitogen-activated protein kinase.
Description: 博士(医学)・甲第605号・平成25年11月27日
URI: http://hdl.handle.net/10564/2670
ISSN: 00070920
Academic Degrees and number: 24601A605
Degree-granting date: 2013-11-27
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2013年度

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