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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/2637

Title: Reduced prefrontal hemodynamic response in pediatric obsessive-compulsive disorder as measured by near-infrared spectroscopy.
Authors: Ota, Toyosaku
Iida, Junzo
Sawada, Masayuki
Suehiro, Yuko
Yamamuro, Kazuhiko
Matsuura, Hiroki
Tanaka, Shohei
Kishimoto, Naoko
Negoro, Hideki
Kishimoto, Toshifumi
Keywords: Pediatric obsessive–compulsive disorder
Near-infrared spectroscopy
Functional neuroimaging study
Prefrontal hemodynamic response
Issue Date: Apr-2013
Publisher: Springer US
Citation: Child psychiatry and human development Vol.44 No.2 p.265-277
Abstract: Recent developments in near-infrared spectroscopy (NIRS) have enabled non-invasive clarification of brain functions in psychiatric disorders. Functional neuroimaging studies of patients with obsessive–compulsive disorder (OCD) have suggested that the frontal cortex and subcortical structures may play a role in the pathophysiology of the disorder. Twelve treatment-naïve children with OCD and 12 age- and sex-matched healthy control subjects participated in the present study after giving consent. The relative concentrations of oxyhemoglobin (oxy-Hb) were measured with prefrontal probes every 0.1 s during the Stroop color-word task, using 24-channel NIRS machines. During the Stroop color-word task, the oxy-Hb changes in the OCD group were significantly smaller than those in the control group in the prefrontal cortex, especially in the frontopolar cortex. The present study suggests that children with OCD have reduced prefrontal hemodynamic response as measured by NIRS.
Description: 博士(医学)・乙第1315号・平成25年7月22日
URI: http://hdl.handle.net/10564/2637
ISSN: 0009398X
Academic Degrees and number: 24601B1315
Degree-granting date: 2013-07-22
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2013年度

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