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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/2636

Title: Coagulation potential of immobilised factor VIII in flow-dependent fibrin generation on platelet surfaces.
Authors: Doi, Masaaki
Sugimoto, Mitsuhiko
Matsui, Hideto
Matsunari, Yasunori
Shima, Midori
Keywords: Haemophilia
von Willebrand factor
factor VIII
flow
Fibrin generation
Issue Date: Aug-2013
Publisher: Schattauer
Citation: Thrombosis and haemostasis Vol.110 No.2 p.316-322
Abstract: Coagulation factor VIII (FVIII) plays an essential role in haemostasis. To date, physiologic activity of FVIII circulating in the bloodstream (S-FVIII) is evaluated by classic coagulation assays. However, the functional relevance of FVIII (-von Willebrand factor complex) immobilised on thrombogenic surfaces (I-FVIII) remains unclear. We used an in vitro perfusion chamber system to evaluate the function of I-FVIII in the process of mural thrombus formation under whole blood flow conditions. In perfusion of either control or synthetic haemophilic blood, the intra-thrombus fibrin generation on platelet surfaces significantly increased as a function of I-FVIII, independent of S-FVIII, under high shear rate conditions. This I-FVIII effect was unvarying regardless of anti-FVIII inhibitor levels in synthetic haemophilic blood. Thus, our results illustrate coagulation potentials of immobilised clotting factors, distinct from those in the bloodstream, under physiologic flow conditions and may give a clue for novel therapeutic approaches for haemophilic patients with anti-FVIII inhibitors.
Description: 博士(医学)・甲第602号・平成25年7月22日
The definitive version is available at " http://dx.doi.org/10.1160/TH13-02-0159 "
URI: http://hdl.handle.net/10564/2636
ISSN: 03406245
Academic Degrees and number: 24601A602
Degree-granting date: 2013-07-22
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2013年度

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