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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/2591

Title: Phosphorylation status of Fas-associated death domain protein is associated with biochemical recurrence after radical prostatectomy
Other Titles: FADDのリン酸化の状態と根治的前立腺全摘除術後の生化学的再発は関連する
Authors: Ikeda, Tomohiro
Tanaka, Nobumichi
Shimada, Keiji
Matsumura, Yoshiaki
Miyake, Makito
Anai, Satoshi
Tomioka, Atsushi
Okajima, Eijiro
Hirayama, Akihide
Fujimoto, Kiyohide
Konishi, Noboru
Hirao, Yoshihiko
Keywords: Prostate cancer
radical prostatectomy
prognostic factor
biochemical recurrence
p-FADD
Issue Date: Mar-2013
Publisher: Elsevier Science
Citation: Urology Vol.81 No.3 p.607-610
Abstract: OBJECTIVE: To assess whether the phosphorylated Fas-associated death domain protein (FADD) at 194 serine (p-FADD) is valuable as a marker of biochemical recurrence in hormone-naive patients who had undergone radical prostatectomy. MATERIALS AND METHODS: We used radical prostatectomy specimens from 106 patients. None of the patients had received neoadjuvant or adjuvant therapy. The percentage of positive p-FADD cells (nuclear staining) was immunohistochemically evaluated. The correlation between FADD phosphorylation and the clinicopathologic parameters was assessed. The correlation between the biochemical recurrence-free rate and the p-FADD expression level was analyzed using the Kaplan-Meier method. RESULTS: Overall, 39 patients developed biochemical recurrence. We investigated the expression of p-FADD in 106 patients with prostate cancer using immunohistochemistry. We compared our findings with the clinicopathologic parameters, including the follow-up data. Patients with a greater positive p-FADD rate had a significantly lower biochemical recurrence rate than those with a lower positive p-FADD rate (P < .001). A significant inverse correlation was found between the positive p-FADD rate and the Gleason score. CONCLUSION: A low expression of p-FADD could be a predictor of biochemical recurrence in hormone-naive patients who have undergone radical prostatectomy.
Description: 博士(医学)・乙第1313号・平成25年5月29日
URI: http://hdl.handle.net/10564/2591
ISSN: 00904295
Academic Degrees and number: 24601B1313
Degree-granting date: 2013-05-29
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2013年度

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