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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/2590

Title: Delayed maturation and differentiation of neurons in focal cortical dysplasia with the transmantle sign: analysis of layer-specific marker expression
Other Titles: “Transmantle sign”を示す限局性皮質異形成における神経細胞の成熟と分化の未熟性:層特異的マーカー発現による解析
Authors: Sakakibara, Takafumi
Sukigara, Sayuri
Saito, Takashi
Otsuki, Taisuke
Takahashi, Akio
Kaneko, Yuu
Kaido, Takanobu
Saito, Yuko
Sato, Noriko
Kimura, Yukio
Nakagawa, Eiji
Sugai, Kenji
Sasaki, Masayuki
Goto, Yu-ichi
Itoh, Masayuki
Keywords: Epilepsy
Focal cortical dysplasia
Layer-specific markers
Neural maturation
Transmantle dysplasia
Transmantle sign
Issue Date: Aug-2012
Publisher: Waverly Press
Citation: Journal of neuropathology and experimental neurology Vol.71 No.8 p.741-749
Abstract: Transmantle dysplasia is a rare type of focal cortical dysplasia (FCD) characterized by expansion of the cortex from the deep white matter to the surface and in which there is a FCD IIA or IIB pathologic pattern. To characterize possible mechanisms underlying this regional disorder of radial migrating cells, we studied the expression patterns of neocortical layer-specific markers using immunohistochemistry in surgical specimens from 5 FCD IIA and 4 FCD IIB cases in children. All neuronal cells expressed the mature neuron marker MAP2/2B but not the microglia markers Iba-1 and CD68. Some layer-specific markers showed distinct expression patterns. TBR1-positive, SATB2-positive, and FOXP1-positive cells were diffusely distributed in the cortex and/or the white matter. TBR1-positive and FOXP1-positive cells were generally more numerous in FCD IIB than in FCD IIA and were mostly in the cortical molecular and upper layers. FOXP1-, FOXP2-, and CUTL1-positive cells also expressed the immature neuron marker, Nestin/PROX1, whereas TBR1-, CTIP2-, and SATB2-positive cells only expressed MAP2/2B. These data highlight differences between FCD IIB and FCD IIA with more cells having the immature marker in upper layer markers in the former. By analyzing layer-specific marker expression patterns, we identified apparent neuronal maturation differences between FCD IIA and FCD IIB in cases of transmantle dysplasia.
Description: 博士(医学)・乙第1312号・平成25年5月29日
URI: http://hdl.handle.net/10564/2590
ISSN: 00223069
Academic Degrees and number: 24601B1312
Degree-granting date: 2013-05-29
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2013年度

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