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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/2587

Title: Lower prefrontal activity in adults with obsessive-compulsive disorder as measured by near-infrared spectroscopy
Other Titles: 近赤外線スペクトロスコピィで測定された成人強迫性障害における前頭前野の活動性の低下
Authors: Okada, koji
Ota, Toyosaku
Iida, Junzo
Kishimoto, Naoko
Kishimoto, Toshifumi
Keywords: obsessive-compulsive disorder
near-infrared spectroscopy
functional neuroimaging study
prefrontal hemodynamic response
Stroop color-word task
Issue Date: 3-Jun-2013
Publisher: Pergamon Press
Citation: Progress in neuro-psychopharmacology & biological psychiatry Vol.43 p.7-13
Abstract: Recent developments in near-infrared spectroscopy (NIRS) have enabled the non-invasive elucidation of the neurobiological underpinnings of psychiatric disorders. Functional neuroimaging studies in human patients have suggested that the frontal cortex and subcortical structures may play a role in the pathophysiology of obsessive-compulsive disorder (OCD). Here we used NIRS to investigate neurobiological function in 12 patients with OCD and 12 age- and sex-matched, healthy control subjects. The relative concentrations of oxyhemoglobin (oxy-Hb) were measured with prefrontal probes every 0.1 sec, during performance of a Stroop color-word task, using 24-channel NIRS. Oxy-Hb changes in the prefrontal cortex of the OCD group were significantly smaller than those in the control group, especially in the left lateral prefrontal cortex. These results suggest that patients with OCD have reduced prefrontal hemodynamic responses as measured by NIRS.
Description: 博士(医学)・甲第599号・平成25年5月29日
URI: http://hdl.handle.net/10564/2587
ISSN: 02785846
Academic Degrees and number: 24601A599
Degree-granting date: 2013-05-29
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2013年度

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