Amphotericin Bの大量経口投与と吸入による深部真菌症の予防の試み ： 造血器悪性腫瘍患者の剖検例5例での検討

Abstract

Autopsy examinations were conducted in five patients with hematological malignancies, especially in search of fungal infections. All of them had several risk factors includind prolonged granulocytopenia, treatment with broad-spectrum antibiotics, anticancer therapy, insertion of central venous catheters and so on. They all received prophylactically large doses of oral amphotericin B suspension (2.4 g/d) as well as inhalation of aerosolized amphotericin B, except for one patient who received only oral therapy, but none of them received intravenous administration. Results of postmortem examinations were : 1) immediate causes of death, without exception, were nonmycotic infections, 2) None of the five patients had signs of fungal colonization throughout the digestive tract or in deep organs.