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GINMU >
01 奈良県立医科大学 >
011 医学部 >
0112 紀要 >
01121 Journal of Nara Medical Association >
Vol.40 No.1 >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10564/2309
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| Title: | 培養肝癌細胞に及ぼすDIBUTYRYL CYCLIC AMPの影響 |
| Other Titles: | EFFECT OF DIBUTYRYL CYCLIC AMP ON THE GROWTH OF CULTURED HEPATOMA CELLS |
| Authors: | 岡本, 康幸
辻井, 啓之
中野, 博
松本, 真
中山, 雅樹
辻井, 正 |
| Keywords: | 肝細胞癌
Bucladesine
HepG2細胞 |
| Issue Date: | 28-Feb-1989 |
| Publisher: | 奈良医学会 |
| Citation: | 奈良医学雑誌 Vol.40 No.1 p.5-9 |
| Abstract: | Effects of dibutyryl cyclic AMP (DBcAMP) on the growth of cultured hepatoma cells were studied with rat Morris hepatoma cells (HTC) and human hepatoma cells (HepG＿2). DBcAMP inhibited DNA synthesis in HTC without cytotoxicity. DBcAMP also induced tyrosine aminotransferase (TAT) in HTC. DBcAMP inhibited DNA synthesis in HepG＿2 at each time point during the 24h-culture. DBcAMP delayed the population doubling time of HepG＿2 and the time at which the percentage of the cells with mitosis reached a peak. These observations suggested that DBcAMP has an inhibitory effect on the growth of hepatoma cells by elongating the cell cycle. |
| URI: | http://hdl.handle.net/10564/2309 |
| ISSN: | 04695550
13450069 |
| Appears in Collections: | Vol.40 No.1
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