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Vol.62 No.6 >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/2295

Title: MOLECULAR MARKERS OF PERITONEAL DISSEMINATION IN GASTRIC CANCER
Authors: Fujii, Kiyomu
Kuniyasu, Hiroki
Keywords: 腫瘍マーカー
胃腫瘍
腫瘍播種
c-met癌原遺伝子蛋白質
染色体欠失
PPAR Gamma
Issue Date: 31-Dec-2011
Publisher: 奈良医学会
奈良県立医科大学
Citation: Journal of Nara Medical Association Vol.62 No.6 p.95-107
Abstract: Peritoneal dissemination is a special condition of gastric cancer metastasis, which worsens the quality of patients' lives and is often difficult to control. In this study, we describe the basic features of the peritoneal dissemination of gastric cancer. Some molecular events are associated with the peritoneal dissemination, including c-met gene amplification, chromosome 7q deletion, and Reg Ⅳ overexpression. Especially, Reg Ⅳ overexpression enhances the antiapoptotic property of gastric cancer cells. In contrast, activation of PPARg inhibits the peritoneal dissemination by the pro-apoptotic effect.
URI: http://hdl.handle.net/10564/2295
ISSN: 13450069
Appears in Collections:Vol.62 No.6

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