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01121 Journal of Nara Medical Association >
Vol.55 No.2 >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/227

Authors: Shimada, Keiji
Nakamura, Mitsutosm
Ishida, Eiwa
Enomoto, Yasunori
Ike, Hiroko
Konishi, Noboru
Keywords: cytology
large cell neuroendocrine careinoma
differential diagnosis
Issue Date: 30-Apr-2004
Publisher: 奈良医学会
Citation: Journal of Nara Medical Association Vol.55 No.2 p.101-105
Abstract: Clinical data or investigation of large cell neuroendocrine carcinoma (LCNEC) have accumulated, some of which however, can be flawed by erroneous cytological diagnosis. In this report, we present a case of LCNEC suspected of originating in the lung, and discuss cytological features Qr differential diagnosis. Aspiration cytology showed clusters of tumor cells with large and polymorphic nuclei and distinct nucleoli. The cytoplasm was positive for some markers for neuroendocrines, is similarly as demonstrated in histological findings of metastasis in the cervical lymph node. LCNEC rapidly develops and often reaches an advanced stage, and we have sometirnes found that fine needle biopsy or cytology is the only tool for pathological suggestion or diagnosis. Therefore, it is necessary to accumulate case reports as presented here and confirm cytological features, which might help us to make an accurate diagnosis of LCNEC and to distinguish it from other neuroendocrine neoplasms including small cell carcinoma or poorly differentiated tumors.
URI: http://hdl.handle.net/10564/227
ISSN: 13450069
Appears in Collections:Vol.55 No.2

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