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Vol.40 No.3 >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/2253

Title: 膜性腎症における間質病変の臨床病理学的研究:生検標本による検討
Authors: 真井, 久夫
土肥, 和紘
松村, 典彦
殿村, 吉正
椎木, 英夫
花谷, 正和
石川, 兵衞
Keywords: 糸球体腎炎-膜性
membranous nephropathy
membranous glomerulonephritis
image analyzer
tubulointerstitial lesions
Issue Date: 30-Jun-1989
Publisher: 奈良医学会
Citation: 奈良医学雑誌 Vol.40 No.3 p.332-338
Abstract: Morphometric investigations of tubulo-interstitial lesions (TIL) were performed in 78 patients with membranous nephropathy. A semi-automatic image analysis system (Leitz Co.) was used for assessment of the TIL in biopsied specimens. The degree of TIL was expressed as the percentage of the damaged area in the cortical interstitium. The measured value of TIL was compared with various clinical indices at the time of biopsy and at final follow-up. TIL in the renal cortex was positively correlated with the serum creatinine level, but it was negatively correlated with endogenous creatinine clearance. TIL was not correlated with severty of glomeruler lesion, urinary protein, or hematuria. The incidence of impaired renal function at the final follow-up increased with the value of TIL. Thus, semiquantitative evaluation of TIL in the renal cortex was considered to be useful in assessing renal function, as well as in the prognosis of membranous nephropathy.
URI: http://hdl.handle.net/10564/2253
ISSN: 04695550
Appears in Collections:Vol.40 No.3

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