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GINMU >
03 紀要 >
031 Journal of Nara Medical Association >
Vol.55 No.2 >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10564/225
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| Title: | ESTRADIOL INDUCES EXPRESSION OF HTLV-I ANTIGENS IN LYMPHOCYTES OF HTLV-I ANTIBODY POSMVE WOMEN |
| Authors: | Matsumoto, Yosmnari
Ando, Yoshiya
Maruya, Chiaki
Enomoto, Masahzlro
Matsuda, Tetsunori |
| Keywords: | HTLV-I
antibody
antigen
sero-coversion
human sera |
| Issue Date: | 30-Apr-2004 |
| Publisher: | 奈良医学会 |
| Citation: | Journal of Nara Medical Association Vol.55 No.2 p.81-86 |
| Abstract: | Pregnant women tested positive for antibodies to human T cell leukemia
virus-I (HTLV-I), even though they had tested negative during a previous pregnancy.
We investigated the correlations between production of HTLV-I antibodies (HTLV-I Ab)
, expression of HTLV-I antigen (HTLV-I Ag), and proliferation of cells due to estrogen
in vitro. Peripheral blood lymphocytes (PBLs) were separated from five HTLV-I
sero-positive non-pregnant women and titration of HTLV-I Ab in sera undertaken.
Cultured PBL were stained by indirect inrmunofluorescence for detection of HTLV-I Ag
expression. It was shown that 17-β estradiol (E2) increased HTLV-I Ab production and
expression in cultured PBL from sero-positive women. These results suggest that
pregnancy stirnulates the production of HTLV-I Ab in women infected with low
concentrations of HTLV-I, but who appear sero-negative, and that this is the reason why
some pregnant women tested positive even though they had tested negative during a
prevlous pregnancy. |
| URI: | http://hdl.handle.net/10564/225 |
| ISSN: | 13450069 |
| Appears in Collections: | Vol.55 No.2
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