シェーグレン症候群における肝病変

Abstract

Sjögren's syndrome (Sjs) may be complicated with hepatic diseases, such as chronic persistent hepatitis, chronic active hepatitis and primary biliary cirrhosis. We examined 14 cases of Sjs complicated with hepatic injury diagnosed by laboratory data. The pathological study of liver biopsies from 13 patients revealed 4 with chronic persistent hepatitis, 4 with chronic active hepatitis and 5 with primary biliary cirrhosis. Abnormal salivary gland lesions were found in 11 of 12 patients with Sjs accompanied with hepatic complications, whereas they were found in 50 of 103 patients with Sjs unaccompanied with hepatic complications. These findings suggest that the development of hepatic complication is associated with that of abnormal salivary gland lesions.