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Vol.41 No.1 >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/2086

Title: OK-432脾臓内投与における抗腫瘍効果の実験的研究
Other Titles: ANTI-TUMOR EFFECT ON INTRASPLENIC INJECTION OF A STREPTOCOCCAL PREPARATION, OK-432
Authors: 佐道, 三郎
Keywords: BRM
immunotherapy
OK-432
intrasplenic injection
Issue Date: 28-Feb-1990
Publisher: 奈良医学会
Citation: 奈良医学雑誌 Vol.41 No.1 p.65-75
Abstract: It is known that a streptococcal preparation, OK-432, is able to induce cytotoxic activity in vivo, and that the spleen has large amounts of immune response cells. thus the therapeutic efficacy of splenic administration of OK-432 was examined. Intrasplenic injection of OK-432 inhibited tumor growth in tumor bearing mice and prolonged the survival rate in metastasis model compared with no injection or intramusclar injection. It was attributed to the cytotoxic activity acquired by splenocyte directly injected with OK-432. These results indicate the effectiveness of intrasplenic injection of OK-432. Intrasplenic injection is considered suitable for clinical application allowing the operation in vitro, too, whereas it has so far been necessary to induce tumoricidal cells in vivo.
URI: http://hdl.handle.net/10564/2086
ISSN: 04695550
13450069
Appears in Collections:Vol.41 No.1

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