OK-432脾臓内投与における抗腫瘍効果の実験的研究

Abstract

It is known that a streptococcal preparation, OK-432, is able to induce cytotoxic activity in vivo, and that the spleen has large amounts of immune response cells. thus the therapeutic efficacy of splenic administration of OK-432 was examined. Intrasplenic injection of OK-432 inhibited tumor growth in tumor bearing mice and prolonged the survival rate in metastasis model compared with no injection or intramusclar injection. It was attributed to the cytotoxic activity acquired by splenocyte directly injected with OK-432. These results indicate the effectiveness of intrasplenic injection of OK-432. Intrasplenic injection is considered suitable for clinical application allowing the operation in vitro, too, whereas it has so far been necessary to induce tumoricidal cells in vivo.