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01121 Journal of Nara Medical Association >
Vol.41 No.4 >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/2053

Title: ニバレノール(マイコトキシン)の代謝と毒性機構に関する研究 : 第一報.ニバレノールの単離精製と新代謝物 ; 脱エポキシニバレノールの同定
Other Titles: STUDIES ON METABOLISM AND TOXICITIES OF NIVALENOL (MYCOTOXIN) : Ⅰ. PURIFICATION OF NIVALENOL AND IDENTIFICATION OF NEW METABOLITE OF NIVALENOL, DEEPOXYNIVALENOL
Authors: 陰地, 義樹
Keywords: trichothecene mycotoxin
nivalenol
deepoxynivalenol
Issue Date: 31-Aug-1990
Publisher: 奈良医学会
Citation: 奈良医学雑誌 Vol.41 No.4 p.325-334
Abstract: Large amounts of two mycotoxins, nivalenol and fusarenon-X were produced from Fusarium graminearum F-1465 cultured on pressed barley. The centrifugal partition chromatography (CPC) using two-phase solvent systems n-butanol-water and chloroform-methanol-water could be applied to a preparative purification of nivalenol and fusarenon-X. Starting from the Fusarium grown on 1 kg of pressed barley substrate, 0.34 g of nivalenol and 0.78 g of fusarenon-X were obtained by recrystallization of CPC fraction from hot methanol. Fusarenon-X was converted to nivalenol by alkaline hydrolysis giving to 0.55 g of crystalline nivalenol. A new metabolite of nivalenol was detected in the feces of rats when nivalenol was administered orally. The new metaboite was identified as 3, 4, 7, 15-tetrahydroxytrichothec-9, 12-dien-8-one, or deepoxynivalenol, on the basis of mass spectrometry and ¹H and ¹³C nuclear magnetic resonance spectroscopy. In repeated oral administration, the deepoxy metabolite was detected in feces at 80% and in urine at 1% of total dose, and the parent compound was detected in feces at 7% and in urine at 1%, respectively.
URI: http://hdl.handle.net/10564/2053
ISSN: 04695550
13450069
Appears in Collections:Vol.41 No.4

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