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01121 Journal of Nara Medical Association >
Vol.41 No.5 >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/2035

Title: 微小変化型ネフローゼ症候群における血清interferon-γ濃度と末梢血単核球interferon-γ産生能
Other Titles: SERUM INTERFERON-γ CONCENTRATION AND INTERFERON-γ PRODUCTION BY PERIPHERAL BLOOD MONONUCLEAR CELLS IN MINIMAL CHANGE NEPHROTIC SYNDROME
Authors: 平山, 俊英
Keywords: interferon-γ
lymphocyte subpopulation
minimal change nephrotic syndrome
nephrotic syndrome
Issue Date: 31-Oct-1990
Publisher: 奈良医学会
Citation: 奈良医学雑誌 Vol.41 No.5 p.451-464
Abstract: The present study was designed to clarify the ability of peripheral blood mononuclear cells (PBMC) from patients with minimal change nephrotic syndrome (MCNS) to produce interferon-γ (IFN-γ) in vitro. Subjects were 35 patients with MCNS, 25 with membranous nephropathy (MN), 42 with IgA nephropathy (IgA-GN), and 23 healthy volunteers as controls. Upon stimulation with phytohemagglutinin and tetradecanoyl phorbol-13-acetate, PBMC of patients with MCNS produced significantly lower amounts of IFN-γ compared to normal healthy volunteers. The reduction of IFN-γ production by PBMC was prominent in the nephrotic stage of MCNS. Decreased production of IFN-γ by PBMC from patients with MCNS returned to normal levels when PBMC were cultured in the presence of autologous serum, suggesting that there may be enhancing factor(s) for IFN-γ production in patient sera. In addition, we have measured the levels of IFN-γ in serum from MCNS. The samples from MCNS in the nephrotic stage had significantly higher levels of IFN-γ than normal healthy volunteers, although the samples from MCNS in incomplete remission and complete remission had normal levels of IFN-γ. Finally, 3 patients of MCNS in the nephrotic stage were found to show a remarkable reduction in their IFN-γ production and an elevation of serum IFN-γ levels. But IFN-γ production and serum IFN-γ levels returned to normal range when the disease was in remission. These findings indicate that disturbance of IFN-γ formation by PBMC and elevation of serum IFN-γ levels may be related to immunological abnormalities in MCNS.
URI: http://hdl.handle.net/10564/2035
ISSN: 04695550
13450069
Appears in Collections:Vol.41 No.5

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