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01121 Journal of Nara Medical Association >
Vol.41 No.6 >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/2019

Title: 表在性膀胱癌に対するBCG膀胱内注入療法の検討
Other Titles: INTRAVESICAL BACILLUS CALMETTE-GUERIN IN THE TREATMENT OF SUPERFICIAL BLADDER CANCER
Authors: 馬場谷, 勝廣
大園, 誠一郎
三馬, 省二
平尾, 佳彦
岡島, 英五郎
青山, 秀雄
佐々木, 憲二
小原, 壮一
森田, 昇
平松, 侃
生間, 昇一郎
山田, 薫
岡本, 新司
塩見, 努
丸山, 良夫
Keywords: superficial bladder cancer
BCG
Issue Date: 31-Dec-1990
Publisher: 奈良医学会
Citation: 奈良医学雑誌 Vol.41 No.6 p.638-643
Abstract: Between March 1988 and September 1989, 29 patients with superficial bladder cancer (Stages CIS, Ta and T1) were treated with intravesical bacillus Calmette-Guerin (BCG). The patients (23 males and 6 females) ranged in age from 42 to 83 years (average 67.4 years). A suspension containing 80 mg of BCG (Tokyo-strain 172) was instilled into the bladder once a week for 8 weeks. Six patients were treated after transurethral resection (TUR-Bt) as prophylaxis. After treamtment, all patients indicate no recurrence at this time. The remaining 23 patients with visible bladder tumor were treated as antitumor effect. Of the 11 patients with CIS, 8 patients (72.7%) were proved to be free of disease by random biopsy and urinary cytology. Three patients (27.5%) had no evidence of CIS by random biopsy and cystoscopy but have persistent positive urinary cytology. As for superficial tumor (Ta, T1), 9 patients (75.0%) had a complete response but another 3 patients (25.0%) indicated no response. Regarding side effects, irritable bladder in 75%, gross hematuria in 27.6% and fever (over 38℃) in 27.6% of patients were observed. These results suggest that intravesical BCG may be useful in the therapy of superficial bladder cancer as well as in the prophylaxis for recurrent tumor following TUR-Bt. However, clinical efficacy and total dose of BCG should be clarified by long term observation.
URI: http://hdl.handle.net/10564/2019
ISSN: 04695550
13450069
Appears in Collections:Vol.41 No.6

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