SLEを伴ったKlinefelter症候群の1例

Abstract

The case of a 36-year-old male patient with Klinefelter's syndrome associated with systemic lupus erythematosus (SLE) is presented. He was diagnosed as SLE and had been treated since the age of 25 years old. Hypogonadism showing loss of pubic hair and testicular atrophy has appeared since the age of 35. LH-RH test showed a pattern of primary hypogonadism. Karyotype analysis showed that he has 47, XXY chromosomes suggestive of Klinefelter's syndrome. Biopsy of his testis revealed hyaline degeneration of seminiferous tubules and absence of spermatocytes. IgG deposition was found in interstitial cells of testicular tissue by immunohistochemistory. These findings suggest that atrophy of testis is due to immunological changes of SLE as well as hormonal changes of Klinefelter's syndrome.