ラットの肝におけるジエチルニトロサミンとフェノバルビタールによる前癌病変の発生に対する食餌性鉄欠乏の抑制効果

Abstract

The effects of dietary iron deficiency on induction of γ-glutamyltransferase (GGT)-positive foci in the liver of rats treated with diethylnitrosamine (DEN) followed by phenobarbital (PB) were studied. The following results were obtained. 1) Dietary iron deficiency for 4 weeks induced an iron dificient anemia and a hepatic iron deficiency in rats. Both the iron deficient anemia and the hepatic iron deficiency were reversed by a 2-week feeding of the basal diet. 2) Dietary iron deficiency for 4 weeks did not alter a hepatic content of cytochrome P450, that of GSH or a peroxidative state of hepatocellular membrane lipids in rats. 3) Induction of GGT-positive foci in the liver of rats initiated with DEN and promoted by PB was significantly inhibited by dietary iron deficiency from 4 weeks before DEN administration throughout the experimental period.