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01121 Journal of Nara Medical Association >
Vol.42 No.4 >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/1968

Title: Hemodilutionに伴うラット視床血流量の変動 : Laser Doppler血流計による連続的測定
Other Titles: EFFECT OF HEMODILUTION ON CEREBRAL BLOOD FLOW : CONTINUOUS MEASUREMENT OF MICROCIRCULATORY REGIONAL CEREBRAL BLOOD FLOW BY LASER-DOPPLER FLOWMETRY
Authors: 奥地, 一夫
平松, 謙一郎
金, 良根
榊, 寿右
Keywords: hemodilution
Laser Doppler flowmeter
rCBF
albumin
hematocrit
Issue Date: 31-Aug-1991
Publisher: 奈良医学会
Citation: 奈良医学雑誌 Vol.42 No.4 p.293-298
Abstract: The object of this investigation is to study the effects of isovolemic hemodilution on regional cerebral blood flow (rCBF) in non-ischemic rats. Regional CBF was measured by Laser-Doppler flowmetery and hydrogen clearance method in the rat's thalamus simultaneously. It is possible for the Laser-Doppler flowmeter (LDF) to make continuous measurement of rCBF. Thirteen Wistar rats were anesthetized with 1.5% halothane by mask. Isovolemic hemodilution was performed to exchange of 7 ml of human albumin for 7 ml rat blood gradually. After this process the values of hematocrit (Hct) decreased from 44.8 to 31.7. The rCBF of the thalamus measured by LDF increased by 25.8%. The increase in rCBF correlated almost linearly with the decrease in Hct. The decrease of mean red cell density caused by hemodilution in the tissue is a decrease factor of CBF which is the theoretical basis of this method. In spite of the decrease factor measured CBF was increased. These data suggest that the remarkable increase in red cells velocity may occur with hemodilution.
URI: http://hdl.handle.net/10564/1968
ISSN: 04695550
13450069
Appears in Collections:Vol.42 No.4

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