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01 奈良県立医科大学 >
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01121 Journal of Nara Medical Association >
Vol.42 No.5 >
このアイテムの引用には次の識別子を使用してください:
http://hdl.handle.net/10564/1949
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タイトル: | 微小変化型ネフローゼ症候群における末梢血単球・マクロファージのinterleukin-1産生能 |
その他のタイトル: | INTERLEUKIN-1 PRODUCTION OF PERIPHERAL BLOOD MONOCYTES/MACROPHAGES IN MINIMAL CHANGE NEPHROTIC SYNDROME |
著者: | 小川, 修二 |
キーワード: | interleukin-1 lymphocyte activating factor minimal change nephrotic syndrome nephrotic syndrom |
発行日: | 1991年10月31日 |
出版者: | 奈良医学会 |
引用: | 奈良医学雑誌 Vol.42 No.5 p.353-362 |
抄録: | The present study was designed to clarify the role of cell-mediated immunity in minimal change nephrotic syndrome (MCNS) by measuring interleukin-1 (IL-1) production of peripheral blood monocytes/macrophages (PBM).
The subjects employed in this study were 25 patients with MCNS, 18 with membranous nephropathy (MN), 32 with IgA nephropathy (IgA-GN), and 30 healthy volunteers as controls. Patients with MN and IgA-GN showed normal levels of IL-1 activity. PBM from patients with MCNS produced significantly higher levels of IL-1 activity compared to
normal healthy volunteers. The increase of IL-1 production by PBM was prominent in the
nephrotic stage of MCNS. Increased production of IL-1 by PBM from patients with MCNS returned to normal when the disease was in remission. In addition, we measured the levels of IL-1α and IL-1β produced by PBM. Patients with MCNS, MN, IgA-GN showed normal
levels of IL-1α. PBM from patients with MCNS produced significantly larger amounts of
IL-1β compared to normal healthy volunteers. Finally, the level of IL-1 activity produced by PBM correlated positively with the level of IL-1β. These findings indicate that increased production of IL-1 by PBM from patients with MCNS may be related to immunological abnormalities in MCNS. |
URI: | http://hdl.handle.net/10564/1949 |
ISSN: | 04695550 13450069 |
出現コレクション: | Vol.42 No.5
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