精神分裂病患者における心房性ナトリウム利尿ペプチド(ANP)とアルギニンバゾプレッシン(AVP)の分泌に関する研究

Abstract

The present study was designed to elucidate the manner of atrial natriuretic peptide (ANP) and vasopressin (AVP) secretion, which involves the development of water intoxication in patients with chronic psychosis. Plasma ANP level and plasma AVP level to plasma osmolality were measured before and after oral water loading in fifteen psychotic patients and in fifteen normal controls. 1) In the patient group, plasma AVP was detected even below 270 mOsm/kg. Sensitivity of AVP secretion to osmolality was lower in the patient group than in the control group. 2) The level of ANP was higher in the patient group than in the control group before and after water loading. There was a negative exponential correlation between ANP level and plasma osmolality in the patient group. 3) From these results, we infer that water intoxication in schizophrenic patients might be 'hypovasopressinemic antidiuresis' (one type of SIADH), linked with ANP secretion.