特発性血小板減少性紫斑病(Idiopathic Thrombocytopenic Purpura : ITP)におけるPAIgG値の検討

Abstract

Measurement of Platelet Associated IgG (PAIgG) in patients with Idiopathic Thrombocytopenic Purpura (ITP) has clinical significance in diagnosis of the disease and evaluation of the prognosis. The value of PAIgG in these patients has been described mostly using fresh washed platelets and enzyme linked immunosorbent assay in previous publications. In this paper, we compare the values using washed freezed-thawed platelets with those of fresh washed platelets in 20 normal individuals. The former value (mean±SD) shows 14.9±4.5 ng/10⁷ pl and the latter 8.0±5.9 ng/10⁷ pl. The correlation coefficient between them was 0.69. In 7 patients with acute ITP, the value of PAIgG was 124.6±94.3 ng/10⁷ pl and the value from 29 patients with chronic ITP was 68.6±113.7 ng/10⁷ pl. In both instances, there was a significant negative correlation between platelet counts and PAIgG values (Y=2.69-0.737X, r=-0.70). This result indicates that washed freezed-thawed platelets can be conveniently used for the determination of PAIgG instead of fresh washed platelets.