本態性低血圧症の心機能に関する研究 ： 交感神経α₁受容体・β受容体刺激薬に対する反応性

Abstract

In order to evaluate the cardiovascular function of patients with essential hypotension, systolic time intervals (STI) in 25 essential hypotensives (Group EH) and 100 healthy adults (Group C) were measured. There were no differences in STI between Group EH and Group C. Furthermore, methoxamine or isoproterenol was intravenously administrated in 15 essential hypotensives (Group L), and 10 healthy volunteers (Group N) for further evaluation of cardiovascular function. Left ventricular ejection time (LVET) of Group L was significantly prolonged and LVET/PEP (PEP ; pre-ejection period) of Group L was elevated compared to those of Group N by infusion of methoxamine, suggesting that cardiac pump function may be accelerated in Group L. When isoproterenol was loaded, LVET of Group N was shortened but LVET of Group L was not changed. The effect of methoxamine on cardiovascular function in Group L may be due to augmentation of contractility of myocardium rather than constriction of resistant vessels through α₁ receptor.