無投薬精神分裂病患者におけるアルギニンバゾプレッシン(AVP)の分泌動態

Abstract

We designed this study to elucidate the manner of arginine-vasopressin (AVP) secretion in non-medicated schizophrenic patients. Plasma AVP level and osmolality (OSM) were measured before and after oral water loading in 14 normal volunteers, 20 non-medicated and 27 medicated schizophrenic patients with psychotropic drugs. Water loading test was performed twice, before and during medication, in the same 13 schizophrenic patients. 1. Simple regression analysis did not show significant differences in AVP secretion manner between the control and non-medicated groups. The sensitivity of AVP secretion response to osmolality in the medicated group was lower than that in the normal control group, suggesting that the psychotropic drug was a major factor in the change of AVP secretion manner. 2. In the medicated patients the basal levels of plasma AVP and ΔAVP/ΔOSM were lower than those in the same and non-medicated patients. 3. Multiple regression analysis in the non-medicated patients revealed associations of the Brief Psychiatric Rating Scale scores to their basal levels of AVP. AVP levels were related positively to acute symptoms and negatively to conceptual disorders in the patients.