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Vol.44 No.5 >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/1773

Title: イヌの膀胱腫瘍における自然史の病理組織学的検討 : Ⅱ. N-butyl-N-(4-hydroxybutyl)nitrosamineにて発生したイヌの膀胱腫瘍の病理組織学的所見のMappingによる検討
Other Titles: HISTOPATHOLOGICAL STUDY OF NATURAL HISTORY OF BLADDER TUMOR IN DOGS : Ⅱ. HISTOPATHOLOGICAL MAPPING STUDY OF THE URINARY BLADDER TUMORS INDUCED BY N-BUTYL-N-(4-HYDROXYBUTYL)NITROSAMINE IN DOGS
Authors: 常深, 邦彦
Keywords: urinary bladder carcinogenesis
natural history of bladder tumor
histopathological analysis
N-butyl-N-(4-hydroxybutyl)nitrosamine
dog
Issue Date: 31-Oct-1993
Publisher: 奈良医学会
Citation: 奈良医学雑誌 Vol.44 No.5 p.313-327
Abstract: Histopathological mapping study was performed on the development and progression of urinary bladder tumor induced by N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) in five adult beagle dogs and four adult mongrel dogs. The results are as follows : 1) Urinary bladder tumors induced by low doses of BBN showed papillary, non-invasive type, G1-2, pTa-1 carcinomas which were similar to human superficial bladder cancer ; 2) Microinvasion was occasionally observed in the papillary, non-invasive tumors induced by low doses of BBN, especially in the proliferated cells with atypia in the lamina propria ; 3) Urinary bladder tumors induced by high doses of BBN showed non-papillary, invasive type, G2-3, pT3b, and carcinoma in situ (CIS), which were similar to human invasive bladder cancer ; 4) No malignant progression was seen in low-grade, low-stage tumors during observation through the whole life of the dogs ; 5) The duration and the total dosage of BBN until bladder tumor occurred in beagle dogs were longer and higher than those of BBN in mongrel dogs ; 6) Those changes such as mild dysplasia and Brunn's nests-like lesion in lamina propria were seen during the development of low grade, papillary and non-invasive bladder tumors induced by low dose of BBN. On the other hand, those changes such as severe dysplasia and carcinoma in situ were seen during the development of non-papillary, invasive transitional cell carcinomas induced by high dose of BBN. The present study suggests that it contributed to knowledge of the natural history of bladder carcinogenesis in dogs, and is a valuable model of bladder carcinoma in humans.
URI: http://hdl.handle.net/10564/1773
ISSN: 04695550
13450069
Appears in Collections:Vol.44 No.5

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