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01121 Journal of Nara Medical Association >
Vol.44 No.6 >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/1763

Title: 放射線照射による食品よりの旋毛虫感染予防に関する研究
Other Titles: EXPERIMENTAL STUDIES ON PREVENTION OF TRICHINOSIS BY FOOD IRRADIATION (Co60)
Authors: 島津, 公隆
Keywords: Trichinella spiralis
Co60 irradiation
prevention of trichinosis
circulating antigen
circulating antibody
Issue Date: 31-Dec-1993
Publisher: 奈良医学会
Citation: 奈良医学雑誌 Vol.44 No.6 p.405-416
Abstract: A systemic study was performed to elucidate the effects of Co60 irradiation on maturation or fecundity of Trichinella spiralis by assessing from parasitological, morphological and immunological points of view. Pieces of muscle tissue of mice infected with T. spiralis were irradiated with Co60 at doses of 50, 75, 100, 150 and 200Gy. These irradiated tissues (Experimental group) and non-irradiated tissues (Control group) were fed to healthy mice. Half of the mice were sacrificed 6 days after the ingestion. The number of adult worms were counted and subjected to statistical analysis, which disclosed a good correlation between the dose of Co60 irradiation and worm damage ; the higher the dose the more damage parasites had, and no adults were recovered if the tissue had been irradiated with more than 150Gy prior to infection. The same tendecy was true for the histopathology of the intestines of host mice ; the higher the dose the less tissue damage. Circulating antigens of T. spiralis and antibodies against T. spiralis were detected in every serum examined by means of ELISA. The remaining mice were sacrificed 30 days after the ingestion. The numbers of muscle larvae were counted and subjected to statistical analysis, which disclosed a good correlation between the dose of Co60 irradiation and worm damage, and no larvae were recovered if the tissue had been irradiated with more than 75Gy. Higher concentrations of circulating antigens of T. spiralis and antibodies against T. spiralis were detected in the serum samples taken with muscle larvae. Thus this study established that Co60 irradiation of more than 150Gy caused complete damage on maturation, and that irradiation of more than 75Gy caused complete damage on the fecundity of T. spiralis.
URI: http://hdl.handle.net/10564/1763
ISSN: 04695550
13450069
Appears in Collections:Vol.44 No.6

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