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01121 Journal of Nara Medical Association >
Vol.44 No.6 >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/1761

Title: 試作人工硝子体ポリビニールアルコールハイドロゲルに対する猿眼の病理組織学的評価
Other Titles: HISTOPATHOLOGICAL EVALUATION IN THE EYES OF RHESUS MONKEYS AFTER INJECTION OF POLYVINYLALCOHOL HYDROGEL AS A VITREOUS SUBSTITUTE
Authors: 原, 徳子
Keywords: artificial vitreous body
polyvinyl alcohol hydrogel
vitreous substitute
Issue Date: 31-Dec-1993
Publisher: 奈良医学会
Citation: 奈良医学雑誌 Vol.44 No.6 p.393-404
Abstract: The purpose of the present experiment is to study by clinical and histological methods the effects of artificial vitreous body made from polyvinyl alcohol hydrogel (PVA) in rhesus monkeys. Fifteen rhesus monkeys were used in the present experiment. Zero point three ml of PVA was injected into the right eye after 0.5 ml of the vitreous body was removed. As a control, 0.3 ml of physiological saline was injected into the left eye, after 0.5 ml of the vitreous body was removed. Clinical laboratory observations were done at 3 days, 1, 2, 4, 8, 12 and 16 weeks after PVA or physiological saline were injected. All eyes were removed at experiment week 16 and were used for histopathological studies. Adequate data could not be obtained in clinical observation, because of difficulty in controlling the intraocular pressure and secondary uveitis, the measurement of which required systemic anesthesia. In histological studies, granulation in outer sclera, mild infiltration of neutrophils, plasma cells and lymphocytes in the iris, granulation on the surface of the sclera, destruction of inner nuclear layer, decrease in the number of outer nuclear cells or fibrin with lymphocytes on the surface of vitreous body were seen in 8 of 12 experimental eyes. Further observations should be done on the adequacy of PVA for vitreous substitute before clinical use.
URI: http://hdl.handle.net/10564/1761
ISSN: 04695550
13450069
Appears in Collections:Vol.44 No.6

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