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Vol.45 No.2 >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/1712

Authors: Ueda, Shigehiko
Yoshikawa, Masahide
Okamoto, Shingo
Tamagawa, Taiko
Tsujinoue, Hirohisa
Ishii, Yoshinobu
Tsuruzono, Takuya
Kawamoto, Hiroshi
Kawata, Mitsuhiro
Yamazaki, Masaharu
Yamamoto, Hiroshi
Moriyasu, Hiroto
Miyamoto, Youji
Kimura, Takaaki
Masui, Kazuhiro
Yamamoto, Kouji
Mitoro, Akira
Mimura, Mayumi
Kyo, Masanaga
Sakamoto, Takemi
Takagi, Masahiro
Fukui, Hiroshi
Tsujii, Tadasu
Keywords: chronic hepatitis C
interferon therapy
thyroid function autoimmune disease
Issue Date: 30-Apr-1994
Publisher: 奈良医学会
Citation: 奈良医学雑誌 Vol.45 No.2 p.192-199
Abstract: In order to evaluate the influnces of IFNα on thyroid function, thyroid-stimulating hormone (TSH), total thyroxine (T4), free T4, tri-iodothyronine (T3), and thyroxine-binding globulin were examined in IFNα-treated 351 patients with chronic hepatitis C before and during therapy. As therapy, either 3 million units (MU) of human lymphoblastoid IFNα or 9MU of recombinant IFNα2a was administrated daily for the initial two weeks followed by three times a week for 22 weeks. There were nine patients showing thyroid dysfunction during IFNα therapy. They consist of one relapse of Graves' disease, one relapse of Hashimoto thyroiditis, one development of apparent thyroid insufficiency from subclinical hypothyroidism, five cases with transient hyperthyroidism and one case with transient hypothyroidism. T4 and T3 levels in most patients who transiently developed thyroid dysfunction were normalized spontaneously after the discontinuation of IFNα. Thyroid-related autoantibodies were positive in 4 patients before IFNα therapy and newly developed in one patient during therapy. Attention should be paid first to the previous histories of autoimmune thyroid diseases and the existence of thyroid-related autoantibodies for the prediction of development of thyroid dysfunction during IFNα therapy. In addition, serial examinations of TSH, T3 and T4 should be also necessary for early detection of transient thyroid dysfunction during IFNα therapy.
URI: http://hdl.handle.net/10564/1712
ISSN: 04695550
Appears in Collections:Vol.45 No.2

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