Cytotoxic chemotherapy施行前における骨髄像検査

Abstract

The present investigation was conducted to evaluate the predictive value of bone marrow examination for myelotoxicity after cytotoxic chemotherapy. A total of 25 patients with urogenital cancer underwent bone marrow examination in the Department of Urology, Nara Medical University and its affiliated hospitals between August 1989 and September 1991. Those parameters including myeloid counts before chemotherapy (M-Number), reticulocyte counts before chemotherapy (Ret), WBC counts before chemotherapy (WBC) and at nadir (N-WBC), interval of the beginning of chemotherapy and nadir (N-Day), interval of recovering days from nadir (R-Day) and N+R-Day were examined. A significant relationship between M-Number and WBC was observed (r=0.367, p=0.016). A negative relationship between WBC and N-Day was observed (r=-0.257, p=0.097). There were also negative relationships between Ret and R-Day (r=-0.337, p=0.068) and between WBC and R-Day (r=-0.254, p=0.084). In addition, a negative relationship could be seen between WBC and N+R-Day (r=-0.306, p=0.061). As for M-Number, however, no relationship with any other parameters concerned with myelotoxicity after chemotherapy was found. Thus, bone marrow examination before cytotoxic chemotherapy did not show a predictive value for myelotoxicity after chemotherapy.