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01 奈良県立医科大学 >
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01121 Journal of Nara Medical Association >
Vol.45 No.4 >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/1652

Title: 脳外科手術患者におけるエンフルレン,イソフルレン,ジアゼパム-フェンタニール麻酔中の脳皮質血流量のCO₂反応性
Other Titles: CARBON DIOXIDE REACTIVITY ON CORTICAL CEREBRAL BLOOD FLOW DURING ENFLURANE, ISOFLURANE AND DIAZEPAM-FENTANYL ANESTHESIA IN NEUROSURGICAL PATIENTS
Authors: 下村, 俊行
Keywords: anesthetics
volatile anesthetics (enflurane, isoflurane)
diazepam-fentanyl anesthesia
thermal clearance method
cerebral blood flow
carbon dioxide reactivity
Issue Date: 31-Aug-1994
Publisher: 奈良医学会
Citation: 奈良医学雑誌 Vol.45 No.4 p.461-468
Abstract: Background : Effects of the CO₂ reactivity on cortical cerebral blood flow (CBF) have not been investigated by non-invasive, non-radioactive procedure in clinical aneshesia (enflurane, isoflurane and diazepam-fentanyl). The purpose of this study is to evaluate the cortical CBF and CO₂ reactivity under anesthesia with a thermal clearance method. Materials and Methods : The CBF were determined by principle of Peltier's effect (thermal clearance method) in 26 patients who have been anesthetized and undergone neurosurgery. The CO₂ reactivities were measured at the clinical steady state of PaCO₂ levels : 35mmHg, 40mmHg and 45mmHg during enflurane (n=8), isoflurane (n=9) and diazepam-fentanyl (n=9)anesthesia, respectively. Results : The CO₂ reactivities of cortical CBF were well maintained during all anesthesia. The slopes of regression line (ΔCBF vs ΔPaCO₂) were 2.74ml・100g⁻¹・min⁻¹・mmHg⁻¹ (enflurane), 1.17ml・100g⁻¹ ・min⁻¹・mmHg⁻¹ (isoflurane) and 1.01ml・100g⁻¹・min⁻¹・mmHg⁻¹ (diazepam-fentanyl). Conclusion : These results suggest that in neurosurgery under enflurane, isoflurane anesthesia, it should be cared for the great reduction of CBF induced by hypocapnic cerebrovascular reactivity.
URI: http://hdl.handle.net/10564/1652
ISSN: 04695550
13450069
Appears in Collections:Vol.45 No.4

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