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01121 Journal of Nara Medical Association >
Vol.45 No.5 >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/1617

Authors: Yoshikawa, Masahide
Fukui, Hiroshi
Takaya, Akira
Matsumura, Masahiko
Uemura, Masahito
Fukui, Kennichi
Kuriyama, Shigeki
Kikuchi, Eiryou
Yamao, Junichi
Matsumoto, Masami
Matsumura, Yoshinobu
Tsujii, Hiroyuki
Nakano, Hiroshi
Tsujii, Tadasu
Keywords: chronic hepatitis C
interferon therapy
liver histology
HCV titer
HCV genotype
Issue Date: 31-Oct-1994
Publisher: 奈良医学会
Citation: 奈良医学雑誌 Vol.45 No.5 p.469-475
Abstract: We investigated the influences of liver histology,serum levels of hepatitis C virus (HCV) and HCV genotypes on responsiveness to interferon (IFN) therapy in 342 patients with chronic hepatitis C. Either 9 million units (MU) of lymphoblastoid alpha IFN or 3 MU of recombinant IFN-alpha was administered daily for 2 weeks and then three times a week for 22 weeks. IFN responses were divided into three groups on the basis of the results of polymerase chain reaction (PCR) assay detecting HCV-RNA in serum. Complete response (CR) was defined as sustained elimination of HCV for at least 6 months after treatment,partial response (PR) as HCV elimination for a limited period,non-response (NR) as continuously positive for HCV-RNA in serum. Quantitation of pre-treament HCV-RNA amount in serum was determined by competitive PCR assay in 47 patients. HCV genotyping was performed in 114 patients by PCR with genotype-specific primers. CR was obtained in 97 patients (28.4%),PR in 104 (30.4%) and NR in 141 (41.2%). IFN responses,represented by CR/PR/NR,were 15/18/11 in 44 patients with chronic persistent hepatitis (CPH),72/65/73 in 210 patients with chronic aggressive hepatitis (CAH) 2a,and 10/21/57 in 88 patients with CAH2b. CR rate was lower in patients with CAH2b (11.4%) compared to those with CPH (34.1%) or CAH2a (34.3%). Averages of pre-treatment serum HCV-RNA amount (copies/50μl) were 10³·⁵⁵ in 13 CRs,10⁴·⁵⁶ in 17 PRs,and 10⁵·⁹⁵ in 17 NRs. There was a positive correlation between pre-treatment HCV-RNA levels and IFN unresponsiveness. HCV genotyping in 114 patients revealed that HCV type Ⅰ infection was observed in one,type Ⅱ in 94,type Ⅲ in 11,type Ⅳ in 6 and mixed (types Ⅱ and Ⅳ) in 2 patients,and their IFN responses (CR/PR/NR) were 0/0/1,28/26/40,3/5/3,1/3/2 and 0/1/1,respectively.
URI: http://hdl.handle.net/10564/1617
ISSN: 04695550
Appears in Collections:Vol.45 No.5

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