無症候性蛋白尿/血尿で発見された膜性増殖性糸球体腎炎5症例の臨床的検討

Abstract

We analyzed the clinical features and prognoses of 5 cases of asymptomatic membranoproliferative glomerulonephritis(MPGN). Two boys and 3 girls were noticed with chance hematuria and/or proteinuria on the mass urine screening system in schools and all presented with persistent hypocomplementemia. Three of them showed typical MPGN form but 2 cases showed an atypical form, focal thickening of basement membrane and double track in light microscopy. All patients were treated with steroid and anticoagulant therapy. Urinary findings improved in 4 cases from 5 months to 8 years after treatment and serum complement was normalized in 3 cases from 10 to 27 months. Rebiopsy was performed in 4 cases and the histological findings were not advanced in all cases but improved in 3 cases. We considered that early detection and treatment may improve the clinical course and prognosis of asymptomatic cases of MPGN.