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Vol.54 No.2 >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/100

Title: Relationship of Metallothionein to Zinc Metabolism During Pregnancy
Authors: Minami, Takeshi
Naganuma, Takashi
Watanabe, Mariko
Takemura, Hideo
Keywords: metallothionein
amniotic fluid
Issue Date: 30-Apr-2003
Publisher: 奈良医学会
Citation: Journal of Nara Medical Association Vol.54 No.2 p.77-82
Abstract: The amounts of metallothionein (MT) and related substances in amniotic fluid and urine were measured, and the role of the MT contained in these fluids was studied. Amniotic fluid without blood was collected during Caesarian sections. Total urine obtained during one day was collected from newborn infants (0-6 days), and spot urine was collected from pregnant women. Sera were also collected. MT in amniotic fluid and urine was measured by radioimmunoassay. In amniotic fluid, a positive relation was observed between MT and β2-microgloblin (MG), but not between MT and zinc. In contrast, a positive relation was observed between MT and zinc in urine of newborn infants, but not between MT and MG. Serum zinc levels were significantly lower in postpartum women than healthy young women, and urinary zinc levels were markedly higher in newborn infants than healthy young women. In conclusion, the level of MT in amniotic fluid may reflect fetal renal function, and another function of MT in the fetus and newborn infant is to supplement zinc in the body.
URI: http://hdl.handle.net/10564/100
ISSN: 13450069
Appears in Collections:Vol.54 No.2

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