http://hdl.handle.net/10564/3770 2020-06 Mon, 06 Apr 2026 12:32:09 GMT 2026-04-06T12:32:09Z http://hdl.handle.net/10564/3774 タイトル: A Case of delayed diagnosis of congenital candidiasis in a Late preterm infant. 著者: Aoki, Hirosato; Tani, Yuki; Tonegawa, Hitoshi; Nakagawa, Takashi; Kamamoto, Tomoyuki; Uchida, Yumiko; Nishikubo, Toshiya 抄録: A female infant was vaginally born at 35 weeks and developed respiratory distress. A rash with pustules gradually appeared on her entire body. Her respiratory condition did not improve with antibacterial treatment. Candida albicans was detected in pharynx, urine, stool, and gastric fluid cultures. Therefore, she was diagnosed with congenital candidiasis (CC) and prescribed fiuconazole. Her respiratory condition rapidly improved after the course of treatment. CC is rare but should be considered in infants with rashes and pustules. Rapid diagnosis is important for a prompt treatment because CC has a high mortality rate, particularly in low-birth-weight infants. However, the diagnosis is challenging when the rash is nonspecific. Paying attention to maternal risk factors, such as the use of intrauterine contraceptive devices, cervical suture, and the use of antibiotics, and to infants' symptoms, including respiratory distress and leukocytosis with left shift may help in a faster diagnosis. 内容記述: 個人の尊厳に関わる画像が掲載されているため本文PDFの登録はなし Mon, 29 Jun 2020 15:00:00 GMT http://hdl.handle.net/10564/3774 2020-06-29T15:00:00Z http://hdl.handle.net/10564/3773 タイトル: がん性サルコペニアに対する栄養介入 著者: 森, 拓也; 川原, 勲; 額賀, 翔太; 宮川, 良博; 後藤, 桂; 大森, 斉; 國安, 弘基 抄録: Most patients with advanced cancer develop skeletal muscle atrophy called sarcopenia, which reduces treatment tolerance and social activity and worsens the prognosis. Glucose suppresses skeletal muscle atrophy in cancer-bearing mice, while promoting cancer growth. In contrast, medium-chain fatty acids reduce skeletal muscle atrophy and suppress cancer growth. Simultaneous administration of glucose and medium-chain fatty acids suppresses skeletal muscle atrophy and eliminates the tumor growth seen with glucose. Based on these findings, dietary intervention using a combination of glucose and medium-chain fatty acids is expected to be effective in suppressing sarcopema in cancer patients. Mon, 29 Jun 2020 15:00:00 GMT http://hdl.handle.net/10564/3773 2020-06-29T15:00:00Z http://hdl.handle.net/10564/3772 タイトル: Applicability of the linear-quadratic model to hypofractionated radiotherapy. 著者: Fujitani, Nobumasa; Yoshimine, Tadashi; Takeda, Maiko; Yamaki, Kaori; Miura, Sachiko; Hasegawa, Masatoshi 抄録: Background: The linear-quadratic (LQ) model is used for evaluating fractionation schedules in radiation oncology. It has been suggested that the biologically effective dose based on the LQ model cannot be applied to hypofractionated radiotherapy. Methods: Glioblastoma cells were transplanted into nude mice. Four equivalent dose fractionation schedules (12 Gy/1 fraction (fr). 15.06 Gy/2 fr, 18.16 Gy/4 fr, and 20.96 Gy/8 fr) were calculated based on the LQ model. The tumor size was measured to evaluate the number of days required for the relative tumor volume to double and become five t imes the initial value (TGD₂ and TGD₅, respectively). A histopathological study was performed after the evaluation of growth delay. Result: The mean TGD₂ of the unirradiated control group and 12 Gy/1 fr, 15.06 Gy/2 fr. 18.16/4 fr, and 20.96 Gy/8 fr groups was 5.69, 22.64, 37.26. 36.81, and 28.96 days, respectively. The mean TGD₅ was 17.83, 48.03. 60.30, 60.40, and 64.94 days, respectively. All TGDs of the irradiated groups were longer than those of the control group. However, no significant differences were observed among the four irradiated groups. Histologically, irregular giant cells were found, but there were no significant differences among the four groups. There was no significant difference in the Ki-67 labeling index and the CD133 and CD44 expression among the groups. Conclusion: The four dose fractionation schedules equivalent to 12 Gy/1 fr yielded comparable responses, suggesting that the LQ model may be applicable to hypofractionated radiotherapy, with a high dose per fraction of up to 12 Gy. 内容記述: 博士（医学）・甲第756号・令和2年9月30日 Mon, 29 Jun 2020 15:00:00 GMT http://hdl.handle.net/10564/3772 2020-06-29T15:00:00Z http://hdl.handle.net/10564/3771 タイトル: 表紙、目次、投稿規定、奥付 (Vol.71 No.1,2,3) Mon, 29 Jun 2020 15:00:00 GMT http://hdl.handle.net/10564/3771 2020-06-29T15:00:00Z