http://hdl.handle.net/10564/2372 2012-08 Mon, 06 Apr 2026 14:23:14 GMT 2026-04-06T14:23:14Z http://hdl.handle.net/10564/2378 タイトル: 公立病院の標榜科と実際の診療に関する考察 著者: 大西, 丈二 Thu, 30 Aug 2012 15:00:00 GMT http://hdl.handle.net/10564/2378 2012-08-30T15:00:00Z http://hdl.handle.net/10564/2377 タイトル: 虫垂粘液嚢胞腺癌の1切除例 著者: 中辻, 直之; 八倉, 一晃; 越智, 祥隆; 堤, 雅弘 抄録: We report a case of mucinous cystadenocarcinoma of the appendix. A 71-year-old women visited our hospital because fecal occult blood test was positive. Colonoscopy showed a round submucosal tumor-like lesion in the cecum. Abdominal CT scan showed a cystic tumor, 3×2 cm in diameter, adjacent to the cecum. A barium enema showed a round submucosal tumor-like lesion in the cecum, without demonstration of the appendix. The hematological tests showed an elevation of serum CEA level. We performed laparotomy with a suspicion of mucinous cystadenoma of the appendix. At the time of the operation, the appendix was swollen and filled with jelly-like mucus. We performed appendectomy because intraoperative pathological diagnosis by frozen section showed no malignancy. But, postoperative final pathological diagnosis revealed mucinous cystadenocarcinoma of the appendix. Ileocecal resection with D2 lymph node dissection was performed on the 17th days after the first operation. Mucinous cystadenocarcinoma of the appendix is comparatively rare and it is difficult to diagnose it preoperatively. Thu, 30 Aug 2012 15:00:00 GMT http://hdl.handle.net/10564/2377 2012-08-30T15:00:00Z http://hdl.handle.net/10564/2376 タイトル: ACUTE HEPATITIS A IN A JAPANESE TRAVELER AFTER OCCURRENCE OF DENGUE FEVER DURING STAY IN INDIA 著者: Sahara, Toshinori; Yoshikawa, Masahide; Ouji, Yukiteru; Nakamura-Uchiyama, Fukumi 抄録: We report a case of acute hepatitis A that developed following an occurrence of dengue fever during a stay in India. The patient was a 52-year-old Japanese man who visited Delhi, India, from September 29 to October 20, 2010. During that stay, he developed a high fever and rash, with thrombocytopenia and slight liver dysfunction (platelet count 7.0×10＾4/μl, AST 94 IU/ml, ALT 63 IU/ml), then was diagnosed with dengue fever on October 14. Soon after returning to Japan, the patient was well, with anti-HA IgM, hepatitis B surface antigen, and anti-hepatitis C all negative, though liver dysfunction transiently worsened. The DENV genome-sequence was not amplified, while IgM and IgG antibodies were detected. In mid-December 2010, one month after returning from India, he noted fatigue and appetite loss. When the patient came to us on January 12, 2011, jaundice was apparent. A laboratory examination revealed highly elevated aminotransferase levels (AST 4002 IU/ml ALT 4715 IU/ml) and positivity for anti-HA IgM, and we made a diagnosis of acute hepatitis A. The clinical course of acute hepatitis A showed smooth improvement without adverse symptoms. By the end of March 2012, the total bilirubin and aminotrasferase levels were completely normalized. We recommend that non-immune individuals be pre-immunized with HA-vaccine and be fully aware of potential health risks at their intended destinations before traveling to endemic countries. Thu, 30 Aug 2012 15:00:00 GMT http://hdl.handle.net/10564/2376 2012-08-30T15:00:00Z http://hdl.handle.net/10564/2375 タイトル: 肝細胞癌におけるstem/progenitor cell markerの免疫組織化学的検討 著者: 高野, 将人; 森田, 剛平; 武田, 麻衣子; 榎本, 泰典; 笠井, 孝彦; 野々村, 昭孝 抄録: Introduction : Recently, stem/progenitor cell marker positive hepatocellular carcinoma (HCC), such as intermediate cell type HCC, CK19 positive HCC and cholangiolocellular carcinoma, has been identified, and stem/progenitor cell origin of liver cancer may have been suggested. The aim of this study was to investigate the expression of stem/progenitor cell marker in case of hepatocellular carcinoma in relation to clinicopathological and morphological features. Materials and methods : Tissue specimens from 65 HCC patients who underwent primary curative hepatectomy between 2007 and 2010 were collected and immunohistochemically analyzed for the expression of CK19, CDC56, c-kit, CD44, and CD133. The correlation between each expression and clinicopathological and morphological factors of HCC patients were evaluated. Results : CK19-positive HCC were observed in 4 (6%) cases. Female gender, metastasis and necrosis of tumor cells were significantly more frequent observed in cases showing positive expression of CK19, and poorly differentiated HCC more frequently expressed CK19 than well/moderately differentiated HCC. Oncocyte-like cells were more frequently observed in CD56-positive HCC (4 cases ; 6%). However, c-kit, CD44, CD133-positive HCC was not found to be associated with any clinicopathological and morphological factors of HCC. Conclusion : Our study suggested that the expression of CK19 in HCC would correlate with female gender, tumor necrosis and metastasis and poor cell differentiation, and CD56 would be associated with oncocyte features of HCC. Thu, 30 Aug 2012 15:00:00 GMT http://hdl.handle.net/10564/2375 2012-08-30T15:00:00Z