DSpace コレクション: 1991-08
http://hdl.handle.net/10564/1964
1991-082024-03-29T08:03:55Z牛骨由来骨形成因子添加骨代用材の異種移植に関する実験的研究
http://hdl.handle.net/10564/1974
タイトル: 牛骨由来骨形成因子添加骨代用材の異種移植に関する実験的研究
著者: 堀内, 克啓
抄録: Fresh autogenous bone graft is generally considered to be the most effective procedure for the repair of bone defects. However, there are some problems such as donor site morbidity and limited quantities. For these reasons, extensive research on
bone substitutes has been done. Bone morphogenetic protein (BMP) induces differentiation of mesenchymal-type cells into cartilage and bone even in xenogeneic extraskeletal sites. However, an appropriate carrier is thought to be required when applied clinically because BMP alone does not induce large amounts of bone formation because of its rapid diffusion. This preliminary report presents xenogeneic osteogenesis in mice using bone substitutes which consisted of BMP and atelocollagen (AC) derived from bovine bones alone. The bovine BMP was purified by utilizing extraction from the demineralized bone matrix (DBM) with 4M guanidine/HCl, followed by differential precipitation, gel filtration
and heparin affinity chromatography. The finally obtained heparin-bound fraction (H-B)
consisted mainly of Mr 22,000 and 18,500 components. Bone AC and pepsinized bone matrix residue gelatin (BMG) were prepared from the guanidine/HCl-extracted DBM by pepsin digestion and differential precipitation. Intramuscular injection of the crude BMP with bone AC solution resulted in reproducible bone induction, and its increase was dose-dependent on the concentration of the AC solution between 0% to 0.5%, followed by a plateau up to 1.0%. However, intermuscular implantation of H-B and bone AC resulted in bone formation only around the periphery of the implant. Moreover, an implant of H-B and BMG induced only slight bone formation resulting from possibly rapid diffusion of BMP. In contrast, an implant of H-B and a carrier consisting of 20% AC and 80% BMG induced the largest deposits of bone formation, the degree of which was superior to allogeneic DBM. Injection of BMP and AC solution was the most reproducible bioassay system and
implantation method. An osteoinductive bone substitute derived entirely from unlimitedly
available bovine bones induced bone formation, even in xenogeneic species. The obtained results suggest a possibility of clinical applications of xenogeneic bone substitutes combined with BMP in osseous reconstruction and augmentation.1991-08-30T15:00:00Z骨髄炎様症状をともなった下顎化骨性線維腫の1症例
http://hdl.handle.net/10564/1973
タイトル: 骨髄炎様症状をともなった下顎化骨性線維腫の1症例
著者: 湯村, 典子; 橋本, 多加; 吉岡, 稔; 川上, 哲司; 松塚, 裕弘; 堀内, 克啓; 杉村, 正仁
抄録: Ossifying fibroma is one of the fibro-osseus lesions, and a benign tumor which has a variety of bone formation in the fibromatous tissue. This report presents a case of an ossifying fibroma of the mandible associated with symptoms similar to an osteomyelitis. The patient was a 34-year-old female complaining of pain in the right submandibular region. The radiographs showed a relatively well-defined radiopaque change containing numerous radiolucent spots extending from the right second premolar to the right mandibular angle. She had hyposthesia of the right lower lip and a fistula with pus discharge in her submandibular region. Four months after her first visit, a radiolucent mass like a sequestrum was revealed radiographically.
After a segmental mandibulectomy preserving the periosteum, mandibular continuity was maintained using A-O reconstructing plate. In the histological findings, most of the tumor consisted of woven bone, and prolifera
tion of the immature fibrous connective tissue was found between trabeculae. The postoperative course was uneventful, and new bone formation induced by the remaining periosteum occurred around the plate.
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http://hdl.handle.net/10564/1972
タイトル: 脳出血後に発見された選択的低アルドステロン症の1例
著者: 松田, 吉史; 野中, 秀郎; 平田, 英二; 佐々木, 嘉彦; 伴, 圭一郎; 上田, 一也; 小川, 修二; 林, 勝文; 清水, 和男; 有吉, 浄治; 石川, 兵衞
抄録: A 54 year-old male who had suffered from an attack of cerebral hemorrhage five months before was admitted because of increasing dizziness and fatigue. Laboratory examinations on admission revealed both hyponatremia and hyperkalemia. Despite the
elevation of plasma renin activity (PRA), plasma aldosterone level was markedly low. Both basal plasma cortisol level and urinary 17-OHCS excretion rate were normal. While cortisol showed a normal response to rapid ACTH infusion test, plasma aldosterone showed
no or very low response to each of the endocrinological tests carried out (rapid ACTH infusion test, angiotensin Ⅱ infusion test and furosemide two-hour standing test). However, PRA showed a marked increase in response to furosemide two-hour standing test. On the basis of these findings, a diagnosis of selective hypoaldosteronism (Type Ⅰ) was entablished. The present disease was probably due to destruction of the zona glomerulosa of the adrenal cortex caused by some autoimmune mechanism.1991-08-30T15:00:00Z超音波内視鏡が診断上有用であった胃隆起性病変の一例
http://hdl.handle.net/10564/1971
タイトル: 超音波内視鏡が診断上有用であった胃隆起性病変の一例
著者: 松田, 吉史; 野中, 秀郎; 船谷, 泰嗣; 小林, 裕子; 東田, 光博; 石川, 兵衞
抄録: A 70-year-old female visited a nearby physician with a complaint of discomfort in the upper abdomen that had lingered for two weeks. X-ray examination revealed the possibility of a gastric tumor. She was referred to the O. P. D. of this hospital
in April, 1987. The endoscopic examination showed a beaded elevated lesion with smooth
surface on the posterior wall of the upper corpus of the stomach. This finding suggested
either varices or submucosal tumor, but a definite diagnosis was not entablished. In November, 1987, endoscopic ultrasonography was carried out and the diagnosis of gastric
varices was established. This type of gastric varices is rarely found in that position. No other varices were found in the esophagus or cardiac region of the stomach. Despite carrying out various examinations, we failed to clarify the cause of this lesion. This lesion was probably due to some kind of vascular malformation. We should recognize the usefulness of endoscopic ultrasonography for differential diagnosis of gastric elevated mass as in such a case as this.1991-08-30T15:00:00Z