2011-12 http://hdl.handle.net/10564/2293 2026-04-09T15:20:21Z 2026-04-09T15:20:21Z 田中, 京子 西川, 武 嶋田, 亜也 森川, 佐和子 武田, 麻衣子 榎本, 泰典 笠井, 孝彦 野々村, 昭孝 須崎, 康恵 植田, 剛 北野, 睦子 小山, 文一 中島, 祥介 http://hdl.handle.net/10564/2297 2017-05-29T06:08:23Z 2011-12-30T15:00:00Z

タイトル: 細胞診で多数の腫瘍細胞が見られた腹膜原発肉腫型悪性中皮腫の一例 著者: 田中, 京子; 西川, 武; 嶋田, 亜也; 森川, 佐和子; 武田, 麻衣子; 榎本, 泰典; 笠井, 孝彦; 野々村, 昭孝; 須崎, 康恵; 植田, 剛; 北野, 睦子; 小山, 文一; 中島, 祥介 抄録: Generally, malignant sarcomatoid mesothelioma (MSM) has few desquamated tumor cells in the ascitic effusion when compared to those of epithelioid type, and is said to present difficulty in cytopathological diagnosis. There are few reports of the cytopathological features of MSM. We report herein cytopathological features of tumor cells found in ascites of a 58-year-old male patient with MSM. In ascitic fluid, sarcomatoid large atypical polygonal and short spindle cells with irregular nuclei, irregular membranous invagination, and distinct nucleoli were seen. Although there is no definite evidence of mesothelial differentiation in sarcomatoid atypical cells in the ascitic fluid by immunostaining, a diagnosis of peritoneal malignant mesothelioma was made according to the histopathological features of a surgical peritoneal sample and the clinical course of this patient. When various sarcomatoid atypical cells are seen in the ascitic fluid, it seems to be necessary to include MSM in the differential diagnosis.

2011-12-30T15:00:00Z Luo, Yi Kuniyasu, Hiroki http://hdl.handle.net/10564/2296 2017-06-11T23:20:26Z 2011-12-30T15:00:00Z

タイトル: MULTIPLE ROLES OF HMGB1 IN CANCER CELLS 著者: Luo, Yi; Kuniyasu, Hiroki 抄録: HMGB1 is a non-histone chromosomal protein, a secretory protein binding to the receptor for advanced glycation end products in cancer cells and monocyte-lineage immune cells. HMGB1 enhances proliferation, motility, invasion, and survival of cancer cells. HMGB1 associated with DNA repair of anti-cancer drug-induced DNA damage. Importantly, HMGB1 is released from necrotic cancer cells and induces re-growth of the remnant cancer cells. In contrast, HMGB1 induces apoptosis in monocyte-lineage immune cells and inhibits tumor-infiltrating macrophages and dendritic cells, lymph node sinus macrophages, liver Kupffer cells to attenuate anti-cancer immune responses and anti-metastatic organ defense.

2011-12-30T15:00:00Z Fujii, Kiyomu Kuniyasu, Hiroki http://hdl.handle.net/10564/2295 2017-06-11T23:20:26Z 2011-12-30T15:00:00Z

タイトル: MOLECULAR MARKERS OF PERITONEAL DISSEMINATION IN GASTRIC CANCER 著者: Fujii, Kiyomu; Kuniyasu, Hiroki 抄録: Peritoneal dissemination is a special condition of gastric cancer metastasis, which worsens the quality of patients' lives and is often difficult to control. In this study, we describe the basic features of the peritoneal dissemination of gastric cancer. Some molecular events are associated with the peritoneal dissemination, including c-met gene amplification, chromosome 7q deletion, and Reg Ⅳ overexpression. Especially, Reg Ⅳ overexpression enhances the antiapoptotic property of gastric cancer cells. In contrast, activation of PPARg inhibits the peritoneal dissemination by the pro-apoptotic effect.

2011-12-30T15:00:00Z http://hdl.handle.net/10564/2294 2017-06-11T23:20:26Z 2011-12-30T15:00:00Z

タイトル: 表紙、目次、総目次、投稿規定詳細、奥付(Vol.62 No.6)

2011-12-30T15:00:00Z