DSpace コレクション: 2004-102004-10http://hdl.handle.net/10564/15662024-03-28T09:01:24Z2024-03-28T09:01:24Z食道表在癌放射線治療著効後に照射野内に発見され内視鏡的治療で根治しえた食道粘膜癌の3例浅川, 勇雄玉本, 哲郎吉村, 均松尾, 祥弘伊藤, 高広中西, 攝子城根, 憲久鎌田, 喜代志http://hdl.handle.net/10564/2512018-04-26T16:30:07Z2004-10-30T15:00:00Zタイトル: 食道表在癌放射線治療著効後に照射野内に発見され内視鏡的治療で根治しえた食道粘膜癌の3例
著者: 浅川, 勇雄; 玉本, 哲郎; 吉村, 均; 松尾, 祥弘; 伊藤, 高広; 中西, 攝子; 城根, 憲久; 鎌田, 喜代志
抄録: In general, salvage EMIR after radiotherapy (RT) is regarded as contra-
indicated in esophageal cancer. We report here three cases of mucosal esophageal cancer
found within the irradiated field of previous RT and treated successfu11y with EMR and
local heating therapy.
Case 1, a 73-year-old man, was diagnosed with operable squamous cell carcinomas
(SCCs) of the esophagus (T1bN0M0: stage I). We performed radical radiotherapy (RT) of
70 Gy and the responses of these tumors were complete response (CR). Twenty-four
months after RT, we found metachronous mucosal esophageal cancer within the irradiated
field. Case 2, a 57-year-old man, was diagnosed with SCCs of the esophagus (T1aN0M0:
stage 0). We tried to perform endoscopic mucosal resection (EMR) for the tumors, but
could not resect them completely. Then, we performed additional RT of 60 Gy for the
residual tumors. The tumor responses were CR. Twenty months after RT, we found
recurrent mucosal esophageal cancer. Case 3, an 81-year-old man, was diagnosed with
SCC of the esophagus (T1bN0M0: stage I). We performed radical RT of 60 Gy because of
his advanced age, and the tumor response was CR. But 6 months after RT, we found
recurrent mucosal esophageal cancer. For these mmors, we performed EMR and local
heating therapy.
In conclusion, these endoscopic treatments may be useful in patients with mucosal
esophageal cancer within the irradiated field.2004-10-30T15:00:00ZSHIFT OF AXIAL POSITION FOR ROTATION AT THE INTERVERTEBRAL JOINT IN DOGSTohno, YoshiyukiTohno, SetsukoAzuma, ChoMoriwake, YumiKumai, TsukasaYamada, Genhttp://hdl.handle.net/10564/2502018-04-26T16:30:06Z2004-10-30T15:00:00Zタイトル: SHIFT OF AXIAL POSITION FOR ROTATION AT THE INTERVERTEBRAL JOINT IN DOGS
著者: Tohno, Yoshiyuki; Tohno, Setsuko; Azuma, Cho; Moriwake, Yumi; Kumai, Tsukasa; Yamada, Gen
抄録: To elucidate whether the position of axis for rotation at the intervertebral
joint is related with the spinal curvature, the authors investigated the spinal columns of
beagles. The spinal column of beagle was composed of 7 cervical, 13 thoracic, 7 lumbar,
3 sacral, and 19 coccygeal vertebrae. It was observed that the position of axis for
rotation at the intervertebral joint was shifted on the superior and inferior views of the
2nd thoracic vertebra and was next shifted on the superior and inferior views of the 10th
thoracic vertebra. It was suggested that in the case of beagle and Wistar rat with 13
thoracic vertebrae, the upper shift of axial position for rotation at the intervertebral joint
occurred on the superior and inferior views of the 2nd thoracic vertebra and the lower
shift of axial position for rotation at the intervertebral joint occurred on the superior and
inferior views of the 10th thoracic vertebra.2004-10-30T15:00:00Z小児胆道拡張症に対するMRCPの有用性と問題点鹿子木, 英毅金廣, 裕道岡山, 順司高, 済峯中島, 祥介北野, 悟廣橋, 伸治豊坂, 昭弘http://hdl.handle.net/10564/2492018-04-18T16:30:06Z2004-10-30T15:00:00Zタイトル: 小児胆道拡張症に対するMRCPの有用性と問題点
著者: 鹿子木, 英毅; 金廣, 裕道; 岡山, 順司; 高, 済峯; 中島, 祥介; 北野, 悟; 廣橋, 伸治; 豊坂, 昭弘
抄録: Evaluation of biliary anatomy and arrangement of the pancreatobiliary
maljunction is critically important in patients with choledochal cysts before surgical
therapy. Although endoscopic retrograde cholangio-pancreatography (ERCP) has been a
golden standard for preoperative evaluation of choledochal cysts, there are some
difficulties in performing this method in pediatric patients due to its invasiveness.
Recently, magnetic resonance cholangiopancreaticography (MRCP) was developed and has
been established as a less invasive diagnostic modality for the pancreatobiliary duct
system. We applied MRCP for ten pediatric patients with choledochal cysts. The bile
duct system was successfully visualized in all cases. Irnages of pancreatobiliary
maljunction were provided from MRCP in 5 of 9 patients who underwent MRCP before
operation. In conclusion, MRCP is a less invasive and quite useful diagnostic modality
for imaging of the pancreatobiliary duct system in pediatric patients with choledochal
cysts.2004-10-30T15:00:00Z銅キレート剤トリエンチンの抗血管新生作用と肝癌発育および肝発癌抑制効果の検討吉井, 純一http://hdl.handle.net/10564/2482018-03-12T16:30:08Z2004-10-30T15:00:00Zタイトル: 銅キレート剤トリエンチンの抗血管新生作用と肝癌発育および肝発癌抑制効果の検討
著者: 吉井, 純一
抄録: Angiogenesis is now recognized to play a pivotal role in tumor
development, and even in the process of carcinogenesis. Trientine dihydrochloride
(trientine) is used in clinical practice as a copper (Cu)-chelating agent. In this study, we
elucidate that the effect of trientine on tumor development and carcinogenesis is due to
the suppression of angiogenesis in the murine hepatocellular carcinoma cell (HCC)
xenograft model and in the rat hepatocarcinogenesis model, respectively. Trientine
suppressed the tumor development associated with suppression of intra-tumoral
angiogenesis. Trientine treatment also resulted in a marked increase of apoptosis in the
tumor, although tumor cell proliferation itself was not altered. In vitro studies also
showed that trientine is not cytotoxic for the tumor cells, but it significantly suppressed
the endothelial cell proliferation. In a diethylnitrosamine (DEN)-induced rat
hepatocarcinogenesis model, trientine treatment significantly suppressed glutathione
S-transferase placental form (GST-P)-positive preneoplastic lesions. Trientine also
markedly suppressed neovascularization in the liver to a similar level as that of
development of preneoplastic lesions. On the contrary, the intrahepatic cell proliferation
was not altered with or without trientine treatment. These results suggested that Cu
plays a pivotal role in HCC tumor development and carcinogenesis via angiogenesis
suppression. Since trientine is already used in clinical practice without any serious side
effects, it may be an effective new strategy for future HCC therapy.2004-10-30T15:00:00Z