2024-03-29T07:02:18Zhttp://ginmu.naramed-u.ac.jp/dspace-oai/request
oai:ginmu.naramed-u.ac.jp:10564/29862017-06-11T23:20:26Zhdl_10564_2982表紙、目次、総目次、投稿規定詳細、奥付(Vol.46 No.6)表紙目次総目次投稿規定詳細奥付奈良医学会奈良県立医科大学2015-03-26T05:52:59Z2015-03-26T05:52:59Z1995-12-31OtherOthers奈良医学雑誌 Vol.46 No.60469555013450069http://hdl.handle.net/10564/298604695550AN00180974奈良医学雑誌466jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/29872017-06-11T23:20:26Zhdl_10564_2982Effect of Dietary Protein Restriction and Nutritional Assessment on Early-Stage Diabetic Nephropathy.Kanauchi, MasaoFujii, YoshihiroHashimoto, ToshioDohi, Kazuhiroanthropometric measurementdiabetic nephropathynutritional statusprotein-limited dieturinary albuminWe evaluated the effects of a protein-limited diet on renal function, urinary albumin excretion and nutritional status of 16 patients with non-insulin dependent diabetes mellitus (11 males and 5 females, mean age 60.5 years) had a urinary albumin excretion rate of between 15 and 200μg/min and were c1assified into two groups : group Ⅰ patients were placed on a protein-limited diet (0.77g/kg/day), and group Ⅱ followed a conventional diabetic diet (1.33g/kg/day). After six months, the value of creatinine c1earance was significantly reduced in group Ⅰ, but urinary albumin excretion did not change in either group. Anthropometric measurements revealed no significant change in body weight, body mass index, arm circumference or triceps skinfold thickness in either group during the study period, but the arm musc1ec ircumference significantly increased in group Ⅰ. No significant differences were observed in either group with regard to serum level of protein, in c1uding total protein, albumin, prealbumin or transferrin, In conc1usion, a protein-limited diet was useful for prevention of diabetic nephropathy in patients with early-stage diabetic nephropathy.奈良医学会奈良県立医科大学2015-03-26T23:35:09Z2015-03-26T23:35:09Z1995-12-31ArticleDepartmental Bulletin Paper奈良医学雑誌 Vol.46 No.6 p.551-5560469555013450069http://hdl.handle.net/10564/298704695550AN00180974奈良医学雑誌466551556engpublisher
oai:ginmu.naramed-u.ac.jp:10564/29882017-06-11T23:20:26Zhdl_10564_2982小児IgA腎症の糸球体内Cross-linked fibrinに関する研究 第一報 : 蛍光抗体法および免疫電顕法による観察Intraglomerular Deposits of Cross-Linked Fibrin in Children with IgA Nephropathy Ⅰ. Immunofluorescent and Immunoelectron Microscopic Observation.山下, 隆司cross-linked fibrinintraglomerular coagulationanti-D-dimer antibodyimmunoelectron microscopyIgA nephropathyTo elucidate the relationship between pathogenesis of glomerular damage and intraglomerular deposits of fibrin/fibrinogen-related antigen (FRA) in children with IgA nephropathy, the localization of FRA was determined by an immunohistopathological method using an anti-fibrinogen antibody capable of detecting FRA, an anti-D-dimer antibody capable of detecting cross-linked fibrin and its derivatives, and by a method using the effect of monochloroacetic acid treatment on kidney sections. The distribution of FRA deposits was divided into four types, and the predictable components were as follows : Type Ⅰ, fibrinogen (Fg) and/or fibrinogen degradation products (FgDP) ; Type Ⅱ, cross-linked fibrin degradation products (XLFbDP) and Fg or FgDP ; Type Ⅲ, a mixture of cross-linked fibrin (XLFb) and Fg, FgDP or XLFbDP ; Type Ⅳ, XLFb predominantly. In patients with Type Ⅲ or Type Ⅳ, mesangial proliferation and/or IgA deposits were observed more intensively within the capillary wall and/or mesangial area than those with Type Ⅰ or Ⅱ, in agreement with the cross-linked fibrin deposits within capillary walls or mesangial area, and the degree of mesangial electron dense deposit (EDD), mesangial interposition or basement membrane thinning on electron microscope was apparently higher in these cases. These findings suggest that intraglomerular coagulation in children with IgA nephropathy may cause glomerular damage.奈良医学会奈良県立医科大学2015-03-27T00:05:33Z2015-03-27T00:05:33Z1995-12-31ArticleDepartmental Bulletin Paper奈良医学雑誌 Vol.46 No.6 p.557-5690469555013450069http://hdl.handle.net/10564/298804695550AN00180974奈良医学雑誌466557569jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/29892017-05-29T06:08:42Zhdl_10564_2982睡眠時無呼吸症候群における無呼吸前後の気管音の解析Characteristics of Tracheal Sound During Breaths Preceding AND Following Apnea in Patients with Sleep Apnea Syndrome中野, 博sleep apnea syndrometracheal soundsnoringacousticsThe author analyzed night tracheal sounds from 15 patients with sleep apnea syndrome. The dominant apnea type of the 15 patients was obstructive in nine, central in three and both in three. Tracheal sound was recorded on a video tape recorder through a microphone attached to anterior neck over the trachea. Simultaneously, signals from an ordinary polysomnograph were digitized and recorded on the hard disc of a personal computer. In each patient ten apnea episodes of each type were selected for analysis. The tracheal sounds during three successive breaths preceding and following the apneas were played back and digitized for subsequent analysis. Short-time power spectra were calculated using a fast-Fourier transform successively and displayed as a form of sound-spectrogram. Mean power spectra during the inspiratory and expiratory phases of each breath were separately calculated and compared with those during breaths while awake. In the cases of obstructive apneas, tracheal sounds preceding apneas contained a snoring sound, on the inspiratory phase in about half of the cases and on the expiratory phase in about 20% of them. In most cases resumed breaths after obstructive apneas started with the abrupt emergence of tracheal sound. The resumed trachal sounds were extremely strong (22.2 dB stronger than breath sounds while awake) : in spection of the time expanded waveform revealed a spike with positive deflection followed by any of irregular noise (47%), snore (35%) or normal breath sound (18%). By contrast, in most cases of central apnea normal breath sounds preceded and followed the apneas, and the ratio of snoring in each breath was 0 to 15%. The tracheal sounds were thought to reflect the pathophysiology of the upper airway in sleep apnea. Analysis of tracheal sound recording could be a useful means not only for detection of apnea events but for determining the type of apnea in diagnosis of sleep disordered breathing.奈良医学会奈良県立医科大学2015-03-27T00:29:33Z2015-03-27T00:29:33Z1995-12-31ArticleDepartmental Bulletin Paper奈良医学雑誌 Vol.46 No.6 p.570-5780469555013450069http://hdl.handle.net/10564/298904695550AN00180974奈良医学雑誌466570578jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/29902017-05-29T06:08:48Zhdl_10564_2982肺胞マクロファージから産生されるInterleukin-1β,Tumor necrosis factor αの石綿肺病態における働きに関する研究The Role of Tumor Necrosis Factorα and Interleukin-1β Produced by Alveolar Macrophages in The Pathogenesis of Pulmonary Asbestosis.徳山, 猛asbestos exposureinterleukin-1βtumor necrosis factor αbronchoalveolar lavagealveolar macrophagepulmonary asbestosisCurrent cocepts of the pathogenesis of fibrotic changes in pulmonary asbestosis implies the roles of alveolar macrophages and cytokines produced by themselves. Tumor necrosis factor α(TNFα) and interleukin-1 β(IL-1β) are multifunctional cytokines produced by alveolar macrophages (AMs), cytokines which regulate inflammation and fibrosis. The aim of this study was to evaluate the role of TNFα and IL-1β secreted by AMs in the pathogenesis of pulmonary asbestosis. We isolated AMs by bronchoalveolar lavage from 11 subjects exposed to asbestos (AE) for a long time (32±8yrs) and from 7healthy controls (HC). AMs were stimulated with/without lipopolysaccharide (10μg/ml) for 24h and supernatants were assayed for TNFα and IL-1β by enzyme linked immunosorbent assay. AMs from AE produced higher levels of TNFα and 1L-1β upon stimulation with lipopolysaccharide than did the cells of HC. TNFα concentrations in BALFs were significantly higher in AE than in HC. IL-1β concentrations in BALFs were very low, and there was no significant difference between AE and HC. TNFα concentrations in BALFs and TNFα production from AMs positively correlated with the percentage of neutrophil in BALFs. AE were divided into two groups by roentogenographic profuound according to the ILO/UC classification (progressive group : more than 2, early group : less than Ⅰ). TNFα concentrations in BALFs were significantly higher in the progressive group than in the early group. In conclusion, these results indicate that TNFα is constitutively secreted by AMs from AE and is possibly associated with the pathogenesis of alveolitis and fibrosis due to asbestos exposure.奈良医学会奈良県立医科大学2015-04-06T00:36:50Z2015-04-06T00:36:50Z1995-12-31ArticleDepartmental Bulletin Paper奈良医学雑誌 Vol.46 No.6 p.579-5860469555013450069http://hdl.handle.net/10564/299004695550AN00180974奈良医学雑誌466579586jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/29912017-06-11T23:20:26Zhdl_10564_2982Localized Right Cerebral Hemisphere Dysfunction, Bereavement and Secondary Mania.Kishimoto, ToshifumiKinoshita, KiyokoKinoshita, HideoOhe, YonejiroNoriyama, YoshinobuTsujimoto, HirokazuKikuchi, AtsushiMori, HarukiIkawa, Genrosecondary maniaright cerebral dysfunctionbereavementlife eventsThe authors report on a fully right-handed man without prior psychiatric history who developed mania secondary to vascular lesion in the right hemisphere immediately after bereavement of his wife. From literature consideration, it is suggested that bereavement is an effective trigger of mania and that right hemisphere dysfunction provides vulnerability for this effect. This case raises important question for both organic and psychological theories of causation of bipolar affective illness.奈良医学会奈良県立医科大学2015-04-06T03:22:24Z2015-04-06T03:22:24Z1995-12-31ArticleDepartmental Bulletin Paper奈良医学雑誌 Vol.46 No.6 p.587-5910469555013450069http://hdl.handle.net/10564/299104695550AN00180974奈良医学雑誌466587591engpublisher
oai:ginmu.naramed-u.ac.jp:10564/29922017-06-11T23:20:26Zhdl_10564_2982Effects of Sultopride and Sulpiride on Serum Prolactin Level in Schizophrenia.Kishimoto, ToshifumiKitera, KatsukiMasuda, NobuakiMatsumoto, HirofumiInohara, JunSudoh, YoshitakaShimayoshi, NoritoNoriyama, YoshinobuUeda, AtsushiAoyama, FukikoMorikawa, MasayukiIkawa, GenroschizophreniasultopridesulpirideprolactindopamineSultopride or sulpiride was administered to 26 schizophrenic patients. In the male patients, there was a significant correlation between serum concentrations of sultopride and sulpiride and prolactin response. In the female patients, there was no significant correlation between them. In sultopride treatment, prolaction response was suggested to be predictive of a good therapeutic response.奈良医学会奈良県立医科大学2015-04-06T06:13:21Z2015-04-06T06:13:21Z1995-12-31ArticleDepartmental Bulletin Paper奈良医学雑誌 Vol.46 No.6 p.592-5980469555013450069http://hdl.handle.net/10564/299204695550AN00180974奈良医学雑誌466592598engpublisher
oai:ginmu.naramed-u.ac.jp:10564/29932017-06-11T23:20:26Zhdl_10564_2982膵頭部癌術後にmyocardial stunningを呈した1例A Case Representing Myocardial Stunning After Surgery for Pancreatic Head Cancer.勝山, 慶之川本, 篤彦藤本, 眞一橋本, 俊雄土肥, 和紘abdominal surgerycardiac catheterizationmyocardial stunningpancreatic head cancerWe report a 60-year-old male with pancreatic head cancer presenting myocardial stunning just after the modified Child operation. He had neither a history of angina pectoris, nor electrocadiographic abnormalities before surgery. On 20 hours after surgery, 12-lead electrocardiogram showed a typical pattern suggesting the existence of acute wide anterior myocardial infarction, that is, ST-elevation in leads Ⅰ, ₐⅤʟ, and Ⅴ₁~Ⅴ₆, although the patient had no chest pain. Emergent cardiac catheterization was performed, and revealed akinesis in the anterior wall on left ventriculogram, while there was no organic stenosis on coronary arteriogram. Peak value of creatinine kinase during his admission was just over the upper limit of normal. Left ventriculogram on the 34th hospital day showed perfectly intact wall motion. Reversible myocardial infaction after abdominal surgery was first reported in 1976 by Kuramoto ; however, the pathophysiology of this phenomenon still remains debatable. This is the first case report presenting myocardial stunning just after pancreatic surgery.奈良医学会奈良県立医科大学2015-04-07T23:56:52Z2015-04-07T23:56:52Z1995-12-31ArticleDepartmental Bulletin Paper奈良医学雑誌 Vol.46 No.6 p.599-6050469555013450069http://hdl.handle.net/10564/299304695550AN00180974奈良医学雑誌466599605jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/29942017-05-29T06:08:42Zhdl_10564_2982糖尿病性ケトアシドーシスで発症し、横紋筋融解症と各種膵酵素の上昇を示した成人発症IDDMの1例A Case of Adult-onset Insulin Dependent Diabetes Mellitus (IDDM) Associated with Ketoacidosis, Rhabdomyolysis and Elevation of Serum Pancreatic Enzyme Levels.赤井, 真弓川野, 貴弘西浦, 公章濱口, 尚重金内, 雅夫土肥, 和紘adult-onset IDDMdiabetic ketoacidosisrhabdomyolysisserum pancreatic enzymeA 57-year-old man with no history of diabetes mellitus was admitted to our hospital because of malaise and impaired consciousness level. The laboratory findings on admission were as follows : plasma glucose 1, 181mg/dl, urine ketone bodies (+), serum amylase 1, 137IU/l, and serum lipase 400IU/l. Elevation of myogenic enzyme, serum-and urine-myoglobin were also observed, so we made a diagnosis of rhabdomyolysis. His diabetes mellitus was well controlled and his general condition improved after saline transfusion and insulin injection. Plasma CPR levels were not detected during admission, and no endogenous insulin secretion was observed on a glucagon tolerance test. These findings suggest that this case is IDDM in spite of his advanced age associated with rhabdomyolysis and elevation of serum pancreatic enzyme levels.奈良医学会奈良県立医科大学2015-04-08T00:37:03Z2015-04-08T00:37:03Z1995-12-31ArticleDepartmental Bulletin Paper奈良医学雑誌 Vol.46 No.6 p.606-6090469555013450069http://hdl.handle.net/10564/299404695550AN00180974奈良医学雑誌466606609jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/29962017-05-29T06:08:51Zhdl_10564_2982ヌードマウス可移植性ヒト胃癌および食道癌株における血管新生阻害剤TNP-470の抗腫療効果に関する研究Effect of Anti-angiogenetic Compound (TNP-470) on Human Gastric and Esophageal Cancer Transplanted into Nude Mice.棚瀬, 真宏anti-angiogenetic compoundhyperthermiaRecently angiogenesis is thought to be necessary for the growth and metastasis of solid tumors. Several anti-angiogenetic compounds which suppress the growth and metastasis of solid tumors have been developed. TNP-470 (o-chloroacetyl-carbamoyl fumagillol), an anti-angiogenetic compound, strongly suppresses the growth of epithelial cells. We determined the effects of TNP-470 alone and in combination with hyperthermia, CDDP or radiation on human gastric and esophageal cancer subcutaneously inoculated into nude mice. In addition, we investigated the effect of TNP-470 on an experimental liver metastasis model using human gastric cancer transplanted into nude mice. The results of experiments using human gastric and esophageal cancer subcutaneously inoculated into nude mice are as follows : 1) TNP-470 alone suppressed the growth of both gastric and esophageal cancer, 2) combination treatment of TNP-470 with hyperthemia suppressed the growth of both gastric and esophageal cancer more strongly than either alone, and 3) it was more effective than the combination treatment of TNP-470 with CDDP or radiation. This study of experimental liver metastasis model demonstrated that TNP-470 alone did not suppress liver metastasis.奈良医学会奈良県立医科大学2015-04-09T01:00:24Z2015-04-09T01:00:24Z1995-12-31ArticleDepartmental Bulletin Paper奈良医学雑誌 Vol.46 No.6 p.610-6220469555013450069http://hdl.handle.net/10564/299604695550AN00180974奈良医学雑誌466610622jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/29972017-06-11T23:20:26Zhdl_10564_2982冠動脈壁におけるAdvanced Glycosylation Endproducts(AGEs)の免疫組織化学的検討Immunohistochemical Analysis of Advanced Glycosylation Endproducts (AGEs) in Coronary Arteries.中村, 義行advanced glycosylation endproducts (AGEs)immunohistochemistrycoronary arterydiabetes mellitusAdvanced glycosylation endproducts (AGEs) accumulate on long-lived extracellular matrix proteins and have been implicated in the micro- and macrovascular complications of diabetes mellitus. Recently developed anti-AGE antibodies were used in an immunohistochemical analysis of coronary arteries obtained from non-insulin dependent diabetic and nondiabetic patients. In the case of diabetes, the incidence of AGEs reactivity is higher in the older group than in the younger group. In the case of nondiabetes, however, there is no difference in the incidence of AGEs reactivity between the two groups. Duration of diabetes mellitus is significantly longer in the AGEs positive group than in the negative group. On the other hand, there is no diffesence in HbA₁c between the AGEs positive and negative groups. Incidence of coronary calcification and degree of coronary stenosis is higher in the AGEs positive group than in the negative group. These data support the role of advanced glycosylation in progressive coronary calcification and coronary stenosis associated with diabetes mellitus.奈良医学会奈良県立医科大学2015-04-09T05:53:58Z2015-04-09T05:53:58Z1995-12-31ArticleDepartmental Bulletin Paper奈良医学雑誌 Vol.46 No.6 p.623-6300469555013450069http://hdl.handle.net/10564/299704695550AN00180974奈良医学雑誌466623630jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/30042017-05-29T06:08:50Zhdl_10564_2982インスリン非依存型糖尿病における腎病変の定量形態学的検討 : (第1報)早期腎病変Quantitative Analysis of Early Morphological Changes in Diabetic Nephropathy with NIDDM.北内, 京子color image processormicroalbuminuriaNIDDMnormoalbuminuiarenal biopsyIncreased urinary albumin excretion (UAE) is a marker of incipient diabetic nephropathy. I examined renal biopsy specimens in patients with normoalbuminuria and microalbuminuria to disclose early morphological changes in non-insulin-dependent diabetes mellitus (NIDDM). Diabetic subjects were 30 patients with normoalbuminuria (group N ; UAE<20μg/min) and 22 patients with microalbuminuria (group M ; 20≦UAE<200μg/min). Ten non-diabetic patients (group C) and their kidney tissue resectedsurgically were compared for reference. Glomerular area (GA), mesangial rate (MR) and percentage of global glomerulosc1erosis (GS) were quantified by light microscopy with a color image processor histomorphometrically. GA was not significantly different in the three groups. In addition, Ccr was not different in the three groups. MR was significantly increased in group N compared with group C (p<0.05), and in group M compared with group C (p<0.0001). MR was also significantly increased in group M compared with group N (p<0.01). GS was not significantly different in the three groups. These results suggest that neither glomerular hypertrophy nor hyperfi1tration exist in NIDDM at the ear1y stage, and mesangial expansion proceeds before the existence of microalbuminuria.奈良医学会奈良県立医科大学2015-04-16T03:29:22Z2015-04-16T03:29:22Z1995-12-31ArticleDepartmental Bulletin Paper奈良医学雑誌 Vol.46 No.6 p.631-6370469555013450069http://hdl.handle.net/10564/300404695550AN00180974奈良医学雑誌466631637jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/30052017-05-29T06:08:50Zhdl_10564_2982インスリン非依存型糖尿病における腎病変の定量形態学的検討 : (第2報)顕性腎症Quantitative Analysis of Morphological Changes in Overt Diabetic Nephropathy with NIDDM.北内, 京子color image processornephrotic syndromeNIDDMovert nephropathyrenal biopsyThe diagnosis of overt diabetic nephropathy is performed by persistent proteinuria (>0.5g/day). I examined renal biopsy specimens in patients with overt diabetic nephropathy, inc1uding patients with nephrotic syndrome, to disclose advanced morphological changes in non-insulin-dependent diabetes mellitus (NIDDM). Diabetic subjects were 9 patients with persistent proteinuria without nephrotic syndrome (group O) and 12 patients with nephrotic syndrome (group NS). Twenty-two diabetic patients with microalbuminuria (20≦urinary albumin excretion<200μg/min) were enrolled for reference (group M). Glomerular area (GA), mesangial rate (MR) and percentage of global glomerulosc1erosis (GS) were quantified by light microscopy with a color image processor histomorphometrically. GA in group NS was significantIy larger than that in group M (p<0.05). MR was significantly increased in group NS compared with both group O (p<0.05) and group M (p<0.0001). GS was significantly increased in both group O and group NS compared with group M (p<0.05). GS was not orrelated with GA in overt diabetic nephropathy. This study shows the existence of glomerular hypertrophy of advanced diabetic nephropathy with nephrotic syndrome in NIDDM. But it was not proved that this hypertrophy took place as a compensatory phenomenon to supplement the decrease of Ccr caused by the existence of global glomerulosc1erosis.奈良医学会奈良県立医科大学2015-04-16T04:02:50Z2015-04-16T04:02:50Z1995-12-31ArticleDepartmental Bulletin Paper奈良医学雑誌 Vol.46 No.6 p.638-6430469555013450069http://hdl.handle.net/10564/300504695550AN00180974奈良医学雑誌466638643jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/30062017-05-29T06:08:44Zhdl_10564_2982甲状腺製剤(チラージンS)が奏功した神経性食息不振症の一例Effects of Thyroxine (T4) on a Patient with Anorexia Nervosa Accompanied by Low T3 Syndrome.西野, さやか澤本, 好克鈴木, 博西野, 正人anorexia nervosaT4 productlow T3 syndromeA 10 year-old girl, diagnosed as anorexia nervosa (AN), had suffered a loss of weight from 33kg to 23kg, and school-phobia during about 10 months. She showed low T3 syndrome at the laboratory examination : T3 0.4ng/ml, T4 4.7μg/ml, TSH 1.2μU/ml and low response of TSH to TRH dose test. Since some psychological treatments had not been effective for her symptoms, we administered a small amount of T4 product in order to improve the low T3 syndrome, which could be one component of the vicious circle on the AN. In this case, the T4 was rather effective : she became cheerful and regained her appetite, gaining 4kg in weight ; laboratory data improved as well. These results suggest that T4 product could be one of the appropriate medicines to treat patients with AN accompanied by low T3 syndrome.奈良医学会奈良県立医科大学2015-04-16T04:32:10Z2015-04-16T04:32:10Z1995-12-31ArticleDepartmental Bulletin Paper奈良医学雑誌 Vol.46 No.6 p.644-6480469555013450069http://hdl.handle.net/10564/300604695550AN00180974奈良医学雑誌466644648jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/30072017-05-29T06:08:53Zhdl_10564_2982我が国のHIV-1感染血友病患者におけるHIV-1 V3領域型特異的抗体に関する研究 : その同定ならびに抗体力価と臨床像との関連Studies on the identification of type-specific antibody against HIV-1 V3 loop, and its clinical significance in HIV-1 infected Japanese hemophiliac.山中, 貴世HIV-1V3-loopprincipal neutralizing determinantanti-PNDмɴ-antibodyhemophiliacsThe V3-domain within gp120 of HIV-1 elicits virus neutralizing antibodies (Ab). In North American-European strains of HIV-1, the GPGR-motif of V3-loop is conserved, whereas in African strains this motif is substituted by GP (or L) GQ. Therefore, a linear amino acid sequence including these motifs is called the principal neutralizing determinant (PND). However, the correlation between clinical stage of HIV-1-infected individuals and anti-PND Ab titers has not yet been well investigated. In this paper, I established that a high frequency (44%) of anti-PND Ab against HIV-1 мɴ strain was observed in 93 seropositive Japanese hemophiliacs using a panel of PND-peptides and an enzyme-linked immunosorbent assay. The cDNA sequence analysis of V3-domain of HIV-1 isolated from patient sera also revealed that the high-responder against PNDмɴ-peptide well conserved the original sequence. Further, based on the determination of anti-PNDмɴ Ab (MN- Ab) titer during the past 10 years, 35 HIV-1-infected Japanese hemophiliacs with a well-characterized natural history were categorized. Group 1 : MN-Ab was consistently negative (<20). Group 2 : MN-Ab titer was within 20-100. Group 3 : MN-Ab titer was initially high, but decreased later. Group 4 : MN-Ab titer was kept high (>100). Patients of group 1 were further divided into two subgroups based on CD4-positive cell count ; namely, subgroup 1a and subgroup 1b. Without exception, the patients belonging to groups 1a, 2, and 3 showed a consistent decrease in CD-4 positive cell counts and a progression to HIV-l-induced disease. Virus isolation test was frequently positive (65-69.4%). In contrast, the patients of group 4 remained asymptomatic carriers. Virus isolation was also less frequent (16.0%). In addition, a marked increase in serum IgA levels was found in many patients of groups 1a, 2, and 3, but this was not seen in any patients of group 4. These results indicate that a high level of anti-PNDмɴ Ab titer in sera well reflects retardation of the disease progression.奈良医学会奈良県立医科大学2015-04-16T23:24:00Z2015-04-16T23:24:00Z1995-12-31ArticleDepartmental Bulletin Paper奈良医学雑誌 Vol.46 No.6 p.649-6640469555013450069http://hdl.handle.net/10564/300704695550AN00180974奈良医学雑誌466649664jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/30082017-05-29T06:08:52Zhdl_10564_2982腎不全におけるエンドセリンの検討Examination of Endothelin in Renal Failure.米田, 龍生hemodialysisrenal transpantationratwarm ischemiaendothelinThe role of Endothelin (ET) in renal failure was evaluated by experimental study using rats (study 1) and clinical study (study 2). In study 1, the change of plasma ET level in renal failure was evaluated in two groups of rats. Group 1 consists of sham operation for left kidney and right nephrectomy, and group 2 consists of 60 minutes warm ischemic damaged left kidney and right nephrectomy. In group 2, plasma ET level increased and was followed with the renal insufficiency. In study 2, the comparison of plasma ET level between the chronic renal failure patients treated with hemodialysis (HD) and those treated with renal transplantation (Tx) was demonstrated. In transplanted patients, periodical change of plasma ET level after renal transplantation was demonstrated. The plasma ET level in HD patients is significantly higher than that of Tx patients. The change in plasma ET level corresponded to renal function. In Tx patients, plasma ET level decreased periodically, followed by the improving of renal function. The results of this study suggest that measurement of plasma ET level is useful as a marker of renal function.奈良医学会奈良県立医科大学2015-04-16T23:55:00Z2015-04-16T23:55:00Z1995-12-31ArticleDepartmental Bulletin Paper奈良医学雑誌 Vol.46 No.6 p.665-6740469555013450069http://hdl.handle.net/10564/300804695550AN00180974奈良医学雑誌466665674jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/30092017-05-29T06:08:52Zhdl_10564_2982温阻血およびサイクロスポリンAによるラット障害腎に対する心房性ナトリウム利尿ペプチド投与による影響Effect of Recombinant Atrial Natriuretic Peptide (R-ANP) on Warm Ischemic and Cyclosporine A-Induced Kidney Damage in Rats.坂, 宗久ratwarm ischemiacyclosporine Arecombinant-atrial natriuretic peptideThe nephrotoxicity of Cyclosporine A (CYA) is a serious problem, and constitutes the major obstacle limiting the use of CYA as an immunosuppressive agent for renal transplantation. On the other hand, the newly described atrial natriuretic peptide (ANP) hormonal system in both humans and animals appears to play an important role in sodium and water excretion. In study 1, the effect of recombinant-ANP (r-ANP) on warm ischemic (WI) damaged kidney was examined in six experimental groups. In study 2, the effects of r-ANP on kidneys damaged by WI followd by CYA administration, which is a similar condition in renal transplantation, were examined in four experimental groups. Consequently, the efficiency of r-ANP on renal function which was damaged by CYA and WI was shown to be verifiable.奈良医学会奈良県立医科大学2015-04-17T00:25:59Z2015-04-17T00:25:59Z1995-12-31ArticleDepartmental Bulletin Paper奈良医学雑誌 Vol.46 No.6 p.675-6870469555013450069http://hdl.handle.net/10564/300904695550AN00180974奈良医学雑誌466675687jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/30102017-05-29T06:08:53Zhdl_10564_2982骨形成因子添加アテロコラーゲン溶液反復注入法による骨造成術に関する実験的研究Bone Augmentation Using Repeated Injection of Atelocollagen Solution with Bone Morphogenetic Protein.稲田, 育久bone morphogenetic protein (BMP)bone augmentationinjectionatelocollagenosteogeneslsBone morphogenetic protein (BMP) induces differentiation of mesenchymal-type cells into cartilage and bone in a number of species. Therefore, BMP has been investigated as an osteoinductive factor for preparation of a bone substitute. This preliminary report presents bone augmentation using repeated injection of atelocollagen (AC) solution with BMP in mice and rats. The crude BMP and bone type Ⅰ atelocollagen were prepared from fresh bovine bones. Intramuscular injection of the AC solution with crude BMP resulted in reproducible bone induction after 2 weeks. BMP activity depended on the concentration of the AC solution as a carrier, and the 0.75% AC solution with BMP induced the highest BMP activity. Repeated injection of the AC solution with BMP did not incite a significant decrease of BMP activity which suggested an immunological response inhibiting osteoinduction. The 3-consecutive-day subperiosteal injection over the rat cranium elicited significantly higher and wider deposits of bone formation than the 3-consecutive-week one after 8 weeks. Moreover, in the 3-consecutive-day injection, each injected implant unified as a mass. On the other hand, in the 3-consecutive-week injection, each induced bone deposit was individually encapsulated by fibrous connective tissues without unification. The repeated injection method of the AC solution with BMP resulted in extensive bone induction easily and reproducibly, in the consecutive-day injection. The results obtained suggest a possibility of c1inical applications of the repeated injection method of the AC solution with BMP not only for bone augmentation but also for all osseous reconstructions, considering the interval,f requency, and location of injection.奈良医学会奈良県立医科大学2015-04-17T00:46:31Z2015-04-17T00:46:31Z1995-12-31ArticleDepartmental Bulletin Paper奈良医学雑誌 Vol.46 No.6 p.688-7030469555013450069http://hdl.handle.net/10564/301004695550AN00180974奈良医学雑誌466688703jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/30112017-05-29T06:08:52Zhdl_10564_2982超音波骨密度測定装置を用いた小児骨密度の検討Growth Related Changes of Bone Mineral Density in Healthy Children, Using an Ultrasound Bone Densitometer.鈴木, 博西野, さやか西野, 正人ultrasound bone densitometerbone mineral densitynormal childrenWe analysed thirty healthy children (15 boys and 15 girls) and four patients under steroid therapy on bone mineral density (BMD), using a newly developed ultrasound bone densitometer. BMD was estimated with the value of stiffness of bone, which was calculated with SOS and BUA. The stiffness in boys increased from 75 to 96 in parallel with aging, as a regression line of Y=67.58±2.27 X. And those in girls showed a regression line of Y=68.38+1.40 X, ranging from 67 to 88. These results were correlative to those using DEXA. The stiffness in four patients under steroid therapy were lower than in healty children. Therefore, we supposed that the ultrasound bone densitometer would be useful for analysis of BMD in children.奈良医学会奈良県立医科大学2015-04-17T05:34:44Z2015-04-17T05:34:44Z1995-12-31ArticleDepartmental Bulletin Paper奈良医学雑誌 Vol.46 No.6 p.704-7080469555013450069http://hdl.handle.net/10564/301104695550AN00180974奈良医学雑誌466704708jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/30122017-06-11T23:20:26Zhdl_10564_2982第116回奈良医学会 : 学会記事第116回奈良医学会学会記事奈良医学会奈良県立医科大学2015-04-17T06:41:08Z2015-04-17T06:41:08Z1995-12-31ArticleDepartmental Bulletin Paper奈良医学雑誌 Vol.46 No.6 p.709-7130469555013450069http://hdl.handle.net/10564/301204695550AN00180974奈良医学雑誌466709713jpnpublisher