2024-03-28T15:21:08Zhttp://ginmu.naramed-u.ac.jp/dspace-oai/request
oai:ginmu.naramed-u.ac.jp:10564/22942017-06-11T23:20:26Zhdl_10564_2293表紙、目次、総目次、投稿規定詳細、奥付(Vol.62 No.6)表紙目次総目次投稿規定奥付奈良医学会奈良県立医科大学OtherOthersJournal of Nara Medical Association Vol.62 No.613450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2294Journal of Nara Medical Association, 62(6)http://hdl.handle.net/10564/2294http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2294/1/%e8%a1%a8%e7%b4%99%e3%80%81%e7%9b%ae%e6%ac%a1%e3%80%81%e7%b7%8f%e7%9b%ae%e6%ac%a1%e3%80%81%e6%8a%95%e7%a8%bf%e8%a6%8f%e5%ae%9a%e8%a9%b3%e7%b4%b0%e3%80%81%e5%a5%a5%e4%bb%98%28Vol.62_No.6%29.pdf13450069AA11252383Journal of Nara Medical Association6262011-12-31jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/22952017-06-11T23:20:26Zhdl_10564_2293MOLECULAR MARKERS OF PERITONEAL DISSEMINATION IN GASTRIC CANCERFujii, KiyomuKuniyasu, Hiroki腫瘍マーカー胃腫瘍腫瘍播種c-met癌原遺伝子蛋白質染色体欠失PPAR GammaPeritoneal dissemination is a special condition of gastric cancer metastasis, which worsens the quality of patients' lives and is often difficult to control. In this study, we describe the basic features of the peritoneal dissemination of gastric cancer. Some molecular events are associated with the peritoneal dissemination, including c-met gene amplification, chromosome 7q deletion, and Reg Ⅳ overexpression. Especially, Reg Ⅳ overexpression enhances the antiapoptotic property of gastric cancer cells. In contrast, activation of PPARg inhibits the peritoneal dissemination by the pro-apoptotic effect.奈良医学会奈良県立医科大学ArticleDepartmental Bulletin PaperJournal of Nara Medical Association Vol.62 No.6 p.95-10713450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2295Journal of Nara Medical Association, 62(6): 95-107http://hdl.handle.net/10564/2295http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2295/1/95-107p%ef%bc%9aMOLECULAR_MARKERS_OF_PERITONEAL_DISSEMINATION_IN_GASTRIC_CANCER.pdf13450069AA11252383Journal of Nara Medical Association626951072011-12-31engpublisher
oai:ginmu.naramed-u.ac.jp:10564/22962017-06-11T23:20:26Zhdl_10564_2293MULTIPLE ROLES OF HMGB1 IN CANCER CELLSLuo, YiKuniyasu, HirokiHMGB1 Proteinマクロファージ自然免疫DNA修復抗腫瘍剤耐性腫瘍HMGB1 is a non-histone chromosomal protein, a secretory protein binding to the receptor for advanced glycation end products in cancer cells and monocyte-lineage immune cells. HMGB1 enhances proliferation, motility, invasion, and survival of cancer cells. HMGB1 associated with DNA repair of anti-cancer drug-induced DNA damage. Importantly, HMGB1 is released from necrotic cancer cells and induces re-growth of the remnant cancer cells. In contrast, HMGB1 induces apoptosis in monocyte-lineage immune
cells and inhibits tumor-infiltrating macrophages and dendritic cells, lymph node sinus macrophages, liver Kupffer cells to attenuate anti-cancer immune responses and anti-metastatic organ defense.奈良医学会奈良県立医科大学ArticleDepartmental Bulletin PaperJournal of Nara Medical Association Vol.62 No.6 p.109-11613450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2296Journal of Nara Medical Association, 62(6): 109-116http://hdl.handle.net/10564/2296http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2296/1/109-116p%ef%bc%9aMULTIPLE_ROLES_OF_HMGB1_IN_CANCER_CELLS.pdf13450069AA11252383Journal of Nara Medical Association6261091162011-12-31engpublisher
oai:ginmu.naramed-u.ac.jp:10564/22972017-05-29T06:08:23Zhdl_10564_2293細胞診で多数の腫瘍細胞が見られた腹膜原発肉腫型悪性中皮腫の一例CYTOPATHOLOGICAL FEATURES OF ASCITES IN A CASE OF PERITONEAL SARCOMATOID MESOTHELIOMA田中, 京子西川, 武嶋田, 亜也森川, 佐和子武田, 麻衣子榎本, 泰典笠井, 孝彦野々村, 昭孝須崎, 康恵植田, 剛北野, 睦子小山, 文一中島, 祥介細胞診中皮腫腹膜腫瘍腹水Generally, malignant sarcomatoid mesothelioma (MSM) has few desquamated tumor cells in the ascitic effusion when compared to those of epithelioid type, and is said to present difficulty in cytopathological diagnosis. There are few reports of the cytopathological features of MSM. We report herein cytopathological features of tumor cells found in ascites of a 58-year-old male patient with MSM. In ascitic fluid, sarcomatoid large atypical polygonal and short spindle cells with irregular nuclei, irregular membranous invagination, and distinct nucleoli were seen. Although there is no definite evidence of mesothelial differentiation in sarcomatoid atypical cells in the ascitic fluid by immunostaining, a diagnosis of peritoneal malignant mesothelioma was made according to the histopathological features of a surgical
peritoneal sample and the clinical course of this patient. When various sarcomatoid atypical cells are seen in the ascitic fluid, it seems to be necessary to include MSM in the differential diagnosis.奈良医学会奈良県立医科大学ArticleDepartmental Bulletin PaperJournal of Nara Medical Association Vol.62 No.6 p.117-12213450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2297Journal of Nara Medical Association, 62(6): 117-122http://hdl.handle.net/10564/2297http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2297/1/117-122p%ef%bc%9a%e7%b4%b0%e8%83%9e%e8%a8%ba%e3%81%a7%e5%a4%9a%e6%95%b0%e3%81%ae%e8%85%ab%e7%98%8d%e7%b4%b0%e8%83%9e%e3%81%8c%e8%a6%8b%e3%82%89%e3%82%8c%e3%81%9f%e8%85%b9%e8%86%9c%e5%8e%9f%e7%99%ba%e8%82%89%e8%85%ab%e5%9e%8b%e6%82%aa%e6%80%a7%e4%b8%ad%e7%9a%ae%e8%85%ab%e3%81%ae%e4%b8%80%e4%be%8b.pdf13450069AA11252383Journal of Nara Medical Association6261171222011-12-31jpnpublisher