2024-03-29T09:29:59Zhttp://ginmu.naramed-u.ac.jp/dspace-oai/request
oai:ginmu.naramed-u.ac.jp:10564/1862017-06-11T23:20:26Zhdl_10564_211km歩行による膝伸展筋の筋活動量の変化について : 大腿直筋・外側広筋・内側広筋の筋持久力における一考察貝谷, 誠久大西, 竜哉弘本, 律子田中, 秀和生駒, 一憲膝伸展筋筋持久力長距離歩行健常者12名を対象に,1km歩行による膝伸展筋(大腿直筋,外側広筋,内側広筋)の筋活動を測定し,長距離歩行が膝伸展筋に与える影響を検討した。歩行開始時に比べ1km歩行時では,大腿直筋の活動量が増加し,外側広筋は減少した。各筋の活動量に性差は見られなかった。特に,大腿直筋は,立脚相前・中期で増加し,外側広筋は,遊脚相中期で減少した。歩行開始時と1km歩行時での各筋の1歩行周期中における最大活動時期では差は見られなかった。膝伸展筋において,長距離歩行の獲得には,大腿直筋の持久力を考慮する必要があると考えられた。日本理学療法士協会2008-06-09T01:37:22Z2008-06-09T01:37:22Z1999-09-30ArticleJournal Article503693 bytesapplication/pdf理学療法学 Vol.26 No.6 p.265-26902893770http://hdl.handle.net/10564/18602893770AN10146032理学療法学266265269jpnhttp://ci.nii.ac.jp/naid/110003996565日本理学療法士協会本文データは学協会の許諾に基づきCiNiiから複製したものであるpublisher
oai:ginmu.naramed-u.ac.jp:10564/1872017-06-11T23:20:26Zhdl_10564_21膝伸展動作と脚伸展動作の反復による膝伸展筋活動の変化について貝谷, 誠久大西, 竜哉弘本, 律子田中, 秀和生駒, 一憲膝伸展動作脚伸展動作反復活動日本理学療法士協会2008-06-09T07:24:19Z2008-06-09T07:24:19Z1999-05-23ArticleJournal Article154045 bytesapplication/pdf理学療法学 Vol.26 Suppl.1 p.6402893770http://hdl.handle.net/10564/18702893770AN10146032理学療法学26Suppl.16464jpnhttp://ci.nii.ac.jp/naid/110003996707日本理学療法士協会本文データは学協会の許諾に基づきCiNiiから複製したものであるpublisher
oai:ginmu.naramed-u.ac.jp:10564/1882017-06-11T23:20:26Zhdl_10564_21膝後十字靱帯不全患者における腓腹筋の代償作用について : 歩行時筋活動を中心に田中, 秀和大西, 竜哉貝谷, 誠久井関, 彩子生駒, 一憲膝後十字靱帯腓腹筋歩行時日本理学療法士協会2008-06-10T02:34:03Z2008-06-10T02:34:03Z2000-04-20ArticleJournal Article176777 bytesapplication/pdf理学療法学 Vol.27 Suppl.2 p.20702893770http://hdl.handle.net/10564/18802893770AN10146032理学療法学27Suppl.2207207jpnhttp://ci.nii.ac.jp/naid/110003997341/日本理学療法士協会本文データは学協会の許諾に基づきCiNiiから複製したものであるpublisher
oai:ginmu.naramed-u.ac.jp:10564/1892017-06-11T23:20:26Zhdl_10564_21片脚立位における下肢筋活動の変化 : 転倒防止に対する訓練の一考察貝谷, 誠久大西, 竜哉田中, 秀和井関, 彩子生駒, 一憲下肢筋転倒防止日本理学療法士協会2008-06-10T04:28:05Z2008-06-10T04:28:05Z2000-04-20ArticleJournal Article166297 bytesapplication/pdf理学療法学 Vol.27 Suppl.2 p.22602893770http://hdl.handle.net/10564/18902893770AN10146032理学療法学27Suppl.2226226jpnhttp://ci.nii.ac.jp/naid/110003997379日本理学療法士協会本文データは学協会の許諾に基づきCiNiiから複製したものであるpublisher
oai:ginmu.naramed-u.ac.jp:10564/1902017-06-11T23:20:26Zhdl_10564_21股関節形成術後患者の筋力トレーニングにおける自覚運動強度と筋活動量の関係 : 筋力トレーニングの至適運動時間の設定における一考察貝谷, 誠久大西, 竜哉尾崎, 由美仲井, 人士筋力トレーニング至適運動時間自覚運動強度日本理学療法士協会2008-06-10T04:36:30Z2008-06-10T04:36:30Z2002-04-20ArticleJournal Article142100 bytesapplication/pdf理学療法学 Vol.29 Suppl.2 p.35502893770http://hdl.handle.net/10564/19002893770AN10146032理学療法学29Suppl.2355355jpnhttp://ci.nii.ac.jp/naid/110003999498日本理学療法士協会本文データは学協会の許諾に基づきCiNiiから複製したものであるpublisher
oai:ginmu.naramed-u.ac.jp:10564/2742017-06-11T23:20:26Zhdl_10564_21股関節接触圧分布についての三次元解析 : 臼蓋回転術の生体力学的検討大根田, 豊股関節接触圧分布三次元解析臼蓋回転術生体力学http://ci.nii.ac.jp/naid/110001096064/バイオメカニズム学会2008-07-03T00:51:04Z2008-07-03T00:51:04Z1988-08-01ArticleJournal Article722287 bytesapplication/pdfバイオメカニズム学会誌 Vol.12 No.3 p.138-14502850885http://hdl.handle.net/10564/27402850885AN00334047バイオメカニズム学会誌 : Journal of the Society of Biomechanisms123138145jpnhttp://ci.nii.ac.jp/naid/110001096064/http://ci.nii.ac.jp/naid/110001096064/バイオメカニズム学会本文データは学協会の許諾に基づきCiNiiから複製したものであるpublisher
oai:ginmu.naramed-u.ac.jp:10564/2752017-06-11T23:20:26Zhdl_10564_21抗てんかん薬服用者における肝機能異常とその治療の試み久永, 学内海, 庄三郎宮本, 誠司岡崎, 孜雄塚本, 澄雄抗てんかん薬肝機能日本てんかん学会2008-07-03T01:03:41Z2008-07-03T01:03:41Z1979-11-19ArticleJournal Article75529 bytesapplication/pdf日本てんかん学会プログラム・抄録集 13回 p.25http://hdl.handle.net/10564/275AA11832791日本てんかん学会プログラム・抄録集132525jpnhttp://ci.nii.ac.jp/naid/110002686569/日本てんかん学会本文データは学協会の許諾に基づきCiNiiから複製したものであるpublisher
oai:ginmu.naramed-u.ac.jp:10564/2762017-06-11T23:20:26Zhdl_10564_21FeCl_3注入ラットによる、急性及び慢性焦点性てんかんモデルの作製多田, 隆興榊, 寿右谷掛, 龍夫宮本, 誠司内海, 庄三郎山本, 浩司堀, 浩ラット急性慢性焦点性日本てんかん学会2008-07-03T01:12:33Z2008-07-03T01:12:33Z1979-11-19ArticleJournal Article55544 bytesapplication/pdf日本てんかん学会プログラム・抄録集 13回 p.54http://hdl.handle.net/10564/276AA11832791日本てんかん学会プログラム・抄録集135454jpnhttp://ci.nii.ac.jp/naid/110002686597/日本てんかん学会本文データは学協会の許諾に基づきCiNiiから複製したものであるpublisher
oai:ginmu.naramed-u.ac.jp:10564/2772017-06-11T23:20:26Zhdl_10564_21monopharmacyとpolypharmacy : 肝機能検査値の面より久永, 学内海, 庄三郎宮本, 誠司塚本, 澄雄monopharmacypolypharmacy肝機能日本てんかん学会2008-07-03T01:17:48Z2008-07-03T01:17:48Z1980-11-07ArticleJournal Article106823 bytesapplication/pdf日本てんかん学会プログラム・抄録集 14回 p.66http://hdl.handle.net/10564/277AA11832791日本てんかん学会プログラム・抄録集146666jpnhttp://ci.nii.ac.jp/naid/110002667819/日本てんかん学会本文データは学協会の許諾に基づきCiNiiから複製したものであるpublisher
oai:ginmu.naramed-u.ac.jp:10564/2782017-06-11T23:20:26Zhdl_10564_21塩化第2鉄注入法による, てんかん焦点の, 組織学的検討多田, 隆興宮本, 誠司内海, 庄三郎山本, 浩司塩化第2鉄注入法てんかん日本てんかん学会2008-07-03T01:28:02Z2008-07-03T01:28:02Z1980-11-07ArticleJournal Article99999 bytesapplication/pdf日本てんかん学会プログラム・抄録集 14回 p.71http://hdl.handle.net/10564/278AA11832791日本てんかん学会プログラム・抄録集147171jpnhttp://ci.nii.ac.jp/naid/110002667829/日本てんかん学会本文データは学協会の許諾に基づきCiNiiから複製したものであるpublisher
oai:ginmu.naramed-u.ac.jp:10564/2792017-06-11T23:20:26Zhdl_10564_21てんかん患者(未治療群と治療群)に対するVPA monotherapy : 特に血清内濃度と臨床効果について宮本, 誠司多田, 隆興角田, 茂田中, 祥弘桐野, 義則京井, 喜久男内海, 庄三郎てんかん患者未治療群治療群VPAmonotherapy血清内濃度臨床効果日本てんかん学会2008-07-03T01:43:40Z2008-07-03T01:43:40Z1987-10-01ArticleJournal Article94056 bytesapplication/pdf日本てんかん学会プログラム・抄録集 21回 p.92http://hdl.handle.net/10564/279AA11832791日本てんかん学会プログラム・抄録集219292jpnhttp://ci.nii.ac.jp/naid/110002668879/日本てんかん学会本文データは学協会の許諾に基づきCiNiiから複製したものであるpublisher
oai:ginmu.naramed-u.ac.jp:10564/2802017-06-11T23:20:26Zhdl_10564_21猫キンドリングモデルにおける抗痙攣剤としてのリドカインの効果田中, 祥弘多田, 隆興内海, 庄三郎桐野, 義則宮本, 誠司京井, 喜久男猫キンドリングモデル抗痙攣剤リドカイン日本てんかん学会2008-07-03T01:49:37Z2008-07-03T01:49:37Z1987-10-01ArticleJournal Article93462 bytesapplication/pdf日本てんかん学会プログラム・抄録集 21回 p.100http://hdl.handle.net/10564/280AA11832791日本てんかん学会プログラム・抄録集21100100jpnhttp://ci.nii.ac.jp/naid/110002668894/日本てんかん学会本文データは学協会の許諾に基づきCiNiiから複製したものであるpublisher
oai:ginmu.naramed-u.ac.jp:10564/2812017-06-11T23:20:26Zhdl_10564_21細胞免疫能からみた抗てんかん薬の選択角田, 茂宮本, 誠司内海, 庄三郎京井, 喜久男榊, 寿右多田, 隆興森本, 哲也平松, 謙一郎細胞免疫能抗てんかん薬日本てんかん学会2008-07-03T01:54:57Z2008-07-03T01:54:57Z1987-10-01ArticleJournal Article103458 bytesapplication/pdf日本てんかん学会プログラム・抄録集 21回 p.163http://hdl.handle.net/10564/281AA11832791日本てんかん学会プログラム・抄録集21163163jpnhttp://ci.nii.ac.jp/naid/110002669021/日本てんかん学会本文データは学協会の許諾に基づきCiNiiから複製したものであるpublisher
oai:ginmu.naramed-u.ac.jp:10564/2822017-06-11T23:20:26Zhdl_10564_21発作焦点とCT : 相関例を中心に京井, 喜久男内海, 庄三郎榊, 壽右多田, 隆興宮本, 誠司発作CT日本てんかん学会2008-07-03T01:59:22Z2008-07-03T01:59:22Z1988-11-07ArticleJournal Article96181 bytesapplication/pdf日本てんかん学会プログラム・抄録集 22回 p.57http://hdl.handle.net/10564/282AA11832791日本てんかん学会プログラム・抄録集225757jpnhttp://ci.nii.ac.jp/naid/110002669039/日本てんかん学会本文データは学協会の許諾に基づきCiNiiから複製したものであるpublisher
oai:ginmu.naramed-u.ac.jp:10564/2832017-06-11T23:20:26Zhdl_10564_21猫扁桃核kindlingの発展過程における髄液内somatostatinの変動中瀬, 裕之物部, 健彦田中, 祥弘多田, 隆興榊, 寿右宮本, 誠司京井, 喜久男内海, 庄三郎猫扁桃核kindling髄液内somatostatin日本てんかん学会2008-07-03T02:08:21Z2008-07-03T02:08:21Z1988-11-07ArticleJournal Article105184 bytesapplication/pdf日本てんかん学会プログラム・抄録集 22回 p.99http://hdl.handle.net/10564/283AA11832791日本てんかん学会プログラム・抄録集229999jpnhttp://ci.nii.ac.jp/naid/110002669095/日本てんかん学会本文データは学協会の許諾に基づきCiNiiから複製したものであるpublisher
oai:ginmu.naramed-u.ac.jp:10564/2842017-06-11T23:20:26Zhdl_10564_21フェリチン注入による焦点性てんかんモデルにおける焦点および対側皮質の経時的組織学的変化桐野, 義則田中, 祥弘多田, 隆興宮本, 誠司京井, 喜久男内海, 庄三郎フェリチン対側皮質日本てんかん学会2008-07-03T04:34:02Z2008-07-03T04:34:02Z1988-11-07ArticleJournal Article84407 bytesapplication/pdf日本てんかん学会プログラム・抄録集 22回 p.169http://hdl.handle.net/10564/284AA11832791日本てんかん学会プログラム・抄録集22169169jpnhttp://ci.nii.ac.jp/naid/110002669232/日本てんかん学会本文データは学協会の許諾に基づきCiNiiから複製したものであるpublisher
oai:ginmu.naramed-u.ac.jp:10564/2852017-06-11T23:20:26Zhdl_10564_21けいれん発症型脳内海綿状血管腫の検討中瀬, 裕之森本, 哲也今西, 正巳二階堂, 雄次角田, 茂久永, 學多田, 隆興榊, 寿右宮本, 誠司京井, 喜久男内海, 庄三郎薮野, 透川合, 省三大西, 英之川口, 正一郎鎌田, 喜太郎けいれん脳内海綿状血管腫日本てんかん学会2008-07-03T04:57:29Z2008-07-03T04:57:29Z1989-10-06ArticleJournal Article93266 bytesapplication/pdf日本てんかん学会プログラム・抄録集 23回 p.89http://hdl.handle.net/10564/285AA11832791日本てんかん学会プログラム・抄録集238989jpnhttp://ci.nii.ac.jp/naid/110002669332/日本てんかん学会本文データは学協会の許諾に基づきCiNiiから複製したものであるpublisher
oai:ginmu.naramed-u.ac.jp:10564/2862017-06-11T23:20:26Zhdl_10564_21てんかん準備性及び痙攣発現機序に関する検討 : 神経ペプチド(ソマトスタチン, TRH)からみた検討中瀬, 裕之多田, 隆興平林, 秀裕田中, 祥弘榊, 寿右宮本, 誠司京井, 喜久男内海, 庄三郎てんかん準備性痙攣発現機序神経ペプチドソマトスタチンTRH日本てんかん学会2008-07-03T05:04:32Z2008-07-03T05:04:32Z1989-10-06ArticleJournal Article93144 bytesapplication/pdf日本てんかん学会プログラム・抄録集 23回 p.124http://hdl.handle.net/10564/286AA11832791日本てんかん学会プログラム・抄録集23124124jpnhttp://ci.nii.ac.jp/naid/110002669399/日本てんかん学会本文データは学協会の許諾に基づきCiNiiから複製したものであるpublisher
oai:ginmu.naramed-u.ac.jp:10564/2932017-06-11T23:20:26Zhdl_10564_21経口避妊薬の生殖器に対する影響とその回復能 (第三回毒性研究会記事)酒井, 健夫螺良, 義彦経口避妊薬生殖器毒性研究会日本トキシコロジー学会2008-07-08T02:17:53Z2008-07-08T02:17:53Z1976-01-15ArticleJournal Article112503 bytesapplication/pdfJournal of toxicological sciences vol.1 No.1 p.10803881350http://hdl.handle.net/10564/29303881350AN00002808Journal of toxicological sciences11108108jpnhttp://ci.nii.ac.jp/naid/110001819995/日本トキシコロジー学会本文データは学協会の許諾に基づきCiNiiから複製したものであるpublisher
oai:ginmu.naramed-u.ac.jp:10564/2942017-06-11T23:20:26Zhdl_10564_21運動失調症およびパーキンソニスムにおける起立時動揺に関する検討榊原, 敏正真野, 行生高柳, 哲也起立動作重心動揺脊髄小脳変性症およびパーキンソン病における起立動作時の前後方向の動揺の分析を行った。この動揺は起立動作開始後, 後方へ移ってそこから安定した立位時のbase lineを越えて前方へ至り, 動揺を繰り返したあと比較的安定した立位の状態になるパターンをとる。脊髄小脳変性症での動揺パターンは起立動作の時間に著明な遅延はないが, 起立直後に大きな振幅の動揺が長く続くのが特徴であり, パーキンソン病の動揺パターンは起立動作に要する時間が延長し, 起立直後に小さな動揺をつくることもあるがすみやかに安定した状態になるのが特徴であった。このような特徴ある動揺パターンは疾患の鑑別や症候の定量化に有益である。日本リハビリテーション医学会2008-07-08T02:27:48Z2008-07-08T02:27:48Z1985-07-18ArticleJournal Article280259 bytesapplication/pdfリハビリテーション医学 Vol.22 No.4 p.221-223188135260034351Xhttp://hdl.handle.net/10564/29418813526AN00250275リハビリテーション医学224221223jpnhttp://ci.nii.ac.jp/naid/110001857979/日本リハビリテーション医学会本文データは学協会の許諾に基づきCiNiiから複製したものであるpublisher
oai:ginmu.naramed-u.ac.jp:10564/2952017-06-11T23:20:26Zhdl_10564_21運動失調症での上肢動作能に対する短期リズムタッピング訓練の効果の検討EFFECTIVENESS OF A RHYTHMAIC EXERCISE FOR ATAXIA森本, 茂真野, 行生高柳, 哲也リズムタッピング運動失調症運動失調症10例でリズムタッピング訓練を行い, 訓練前後でタッピングテストにてタッピングの interval, duration time を測定し, 時間的正確性, 運動方向変換能を検討した。運動失調症では, interval, duration の延長があり, 特に duration の分散は左手で大きかった。リズムタッピング訓練は, 時間的正確性に対して7例で効果があったがその程度は様々であり, 3例においては効果を認めなかった。訓練による学習の受け入れ, 記憶, 呼び出しの過程のどこかに障害があると, 訓練効果は得られなかったり動作能に陰性的に働くと推定した。クロックパルスの障害と, 動作能の障害あるいはリズムタッピング訓練効果と関連がある可能性を推測した。In 10 patients suffering from ataxia, we examined the effect on upper limb function of a tapping exercise performed in time to a rhythmic sound. Eight of the patinets had spinocerebeller degeneration, one had tabes dorsalis, and the remaining patient had severely impaired deep sensation in the upper limbs secondary to an abnormality at the atlas and axis. The rhythmic tapping exercise consisted of alternately tapping two points in time to a beep tone rhythmically generated from a computer. Forty taps comprised one performance of the exercise. The beep tone was emitted at rates of 40,60,80,…, 200 beeps per minute. The right hand and the left hand each performed the series of taps at the defferent beep rates. Motor skill was assessed by measuring the interval between successive taps and the duration of the press for each tap. These temporal measures were sampled on line by an MSX computer to which the device for pressing was wired. The rhythmic tapping exercise was effective, though to varying degrees, in seven of the subjects. The remaining three subjects experienced on beneficial effect from the exercise, and in fact performance even became worse in some instances. Failure to improve may have been due to impairment somewhere in the motor lerning system of the cerebellum. If the body can be considered to have a clock-pulse function something like that of a computer, the rhythmic tapping exercise might not help improve motor skill of the hands in patients wheos internal clock-pulse functions are impaired.日本リハビリテーション医学会2008-07-08T06:33:34Z2008-07-08T06:33:34Z1986-05-18ArticleJournal Article560763 bytesapplication/pdfリハビリテーション医学 Vol.23 No.3 p.125-130188135260034351Xhttp://hdl.handle.net/10564/29518813526リハビリテーション医学233125130jpnhttp://ci.nii.ac.jp/naid/110001858167/日本リハビリテーション医学会本文データは学協会の許諾に基づきCiNiiから複製したものであるpublisher
oai:ginmu.naramed-u.ac.jp:10564/2962017-06-11T23:20:26Zhdl_10564_21健常正常人における求心性筋収縮, 遠心性筋収縮時の肘関節屈曲力の検討STUDY OF THE DIFFERENCE BETWEEN CONCENTRIC AND ECCENTRIC TORQUE OF ELBOW FLEXOR MUSCLES小西, 敏彦真野, 行生堀川, 博誠高柳, 哲也森本, 茂等運動性筋収縮肘関節屈曲力The purpose of this study was to determine the torque-velocity relationship between concentric and eccentric contration of elbow flexor muscles. Elbow flexor torques of nine healthy men (29.3±8.7ys) were measured during concentric and eccentric contraction with an isokinetic dynamometer at velocities of 10,30,60 and 120 deg./sec. Peak torque at each velocity of nine subjects was measured to determine the torque-velocity relationship. And the ratio of peak torque of concentric contraction to that of eccentric contraction (EMC/CMC) was calculated. Stabilization straps were used to prevent the shoulder and girdle sliding in order to prevent the error between movement of arm and movement of dynamometer. The significant difference was observed between the torque of concentric and eccentric contraction at the same angular velocity (p<0.001). At the eccentric contraction the torque at 10 deg/sec was significantly lower than that at 30,60,120 deg/sec (p<0.01). At the concentric contraction the torque reached the maximum at 30 deg/sec. But no significant change of the torque was observed at concentric contracton. Significant difference existed between EMC/CMC ratio at 10 deg/sec and that at 30,60 and 120 deg/sec (p<0.001). From these findings the following conclusion can be reached that the difference existed between the torque of concentric and eccentric contraction. The greater torque of EMC than that of CMC might be the result of fascilitation of motor unit due to long loop reflex during the stretch of muscle. The follwing fact was reported that stretch of the twitched single muscle fiber caused the enhancement of muscle fiber force. These mechanism may explain the result in this study.日本リハビリテーション医学会2008-07-08T07:10:53Z2008-07-08T07:10:53Z1989-09-18ArticleJournal Article736943 bytesapplication/pdfリハビリテーション医学 Vol.26 No.5 p.399-403188135260034351Xhttp://hdl.handle.net/10564/29618813526AN00250275リハビリテーション医学265399403jpnhttp://ci.nii.ac.jp/naid/110001852416/日本リハビリテーション医学会本文データは学協会の許諾に基づきCiNiiから複製したものであるpublisher
oai:ginmu.naramed-u.ac.jp:10564/2972017-06-11T23:20:26Zhdl_10564_21筋萎縮性側索硬化症と多発性硬化症のリハビリテーション眞野, 行生筋萎縮性側索硬化症多発性硬化症日本リハビリテーション医学会2008-07-08T07:22:45Z2008-07-08T07:22:45Z1991-01-18ArticleJournal Article546216 bytesapplication/pdfリハビリテーション医学 Vol.28 No.1 p.39-43188135260034351Xhttp://hdl.handle.net/10564/29718813526AN00250275リハビリテーション医学2813943jpnhttp://ci.nii.ac.jp/naid/110001859865/日本リハビリテーション医学会本文データは学協会の許諾に基づきCiNiiから複製したものであるpublisher
oai:ginmu.naramed-u.ac.jp:10564/2982017-06-11T23:20:26Zhdl_10564_21障害者の動作分析 : 新しい歩行分析法による検討安東, 範明眞野, 行生障害者歩行日本リハビリテーション医学会2008-07-09T01:27:45Z2008-07-09T01:27:45Z1994-07-18ArticleJournal Article550617 bytesapplication/pdfリハビリテーション医学 Vol.31 No.7 p.483-489188135260034351Xhttp://hdl.handle.net/10564/29818813526AN00250275リハビリテーション医学317483489jpnhttp://ci.nii.ac.jp/naid/110001862410/日本リハビリテーション医学会本文データは学協会の許諾に基づきCiNiiから複製したものであるpublisher
oai:ginmu.naramed-u.ac.jp:10564/2992017-06-11T23:20:26Zhdl_10564_21SMONの重心動揺と中枢運動神経伝導時間 : 高齢者群との比較A Comparison of Stabilogram Findings between Patients with SMON and Elderly Healthy Subjects荒木, 克仁眞野, 行生藤本, 泰代高柳, 哲也森本, 茂スモン重心動揺中枢運動神経伝導時間SMONbody swaycentral motor conduction time (CMCT)立位保持可能なSMON患者と高齢者に重心動揺検査を行い,その立位能を比較し,重心動揺に影響する因子について検討した。SMON患者を歩行能で2群に分けそれぞれを高齢者群と比較した場合,歩行能がより障害されている杖歩行群で,重心動揺距離,面積が有意に大きく,皮質脊髄路などの障害の指標となる中枢運動神経伝導時間も有意に遅延していた。SMON患者では中枢運動神経伝導時間と重心動揺距離が高い相関を示した。SMON患者のうち杖歩行群では重心動揺は大きくなり,CMCTの遅延と重心動揺の障害が並行して出現することが明らかにされた。In 16 patients with SMON (group S) and 35 elderly healthy controls (group A), stabilograms were recorded for 15 seconds with the eyes open. Group S was divided into two subgroups : group S1, comprised of patients who did not need support in walking, and group S2, comprised of patients who required support in walking. Stability was statistically worse in group S2 than in groups A and S1, although there was no difference in stability between group S1 and group A. Similarly, central motor conduction time (CMCT) was prolonged in group S2, compared with groups A and S1. In group S, there was a good correlation between stability and CMCT ; the worse a patient's stability was, the slower CMCT was. In SMON, patients with disability in walking have worse stability than those without disability in walking. This finding suggests that impaired stability parallels central motor system impairment.日本リハビリテーション医学会2008-07-09T01:34:58Z2008-07-09T01:34:58Z1994-08-18ArticleJournal Article231343 bytesapplication/pdfリハビリテーション医学 Vol.31 No.8 p.559-561188135260034351Xhttp://hdl.handle.net/10564/29918813526AN00250275リハビリテーション医学318559561jpnhttp://ci.nii.ac.jp/naid/110001862419/日本リハビリテーション医学会本文データは学協会の許諾に基づきCiNiiから複製したものであるpublisher
oai:ginmu.naramed-u.ac.jp:10564/3082017-06-11T23:20:26Zhdl_10564_21筋疲労について : 1994年/第31回日本リハビリテーション医学会学術集会/幕張眞野, 行生筋疲労日本リハビリテーション医学会2008-07-09T06:05:03Z2008-07-09T06:05:03Z1994-09-18ArticleJournal Article299303 bytesapplication/pdfリハビリテーション医学 Vol.31 No.9 p.622-62618813526http://hdl.handle.net/10564/30818813526AN00250275リハビリテーション医学319622626jpnhttp://ci.nii.ac.jp/naid/110001862429/日本リハビリテーション医学会本文データは学協会の許諾に基づきCiNiiから複製したものであるpublisher
oai:ginmu.naramed-u.ac.jp:10564/3102017-06-11T23:20:26Zhdl_10564_212連続経頭蓋的磁気刺激による運動誘発電位 : 安静時と収縮時との比較生駒, 一憲矢倉, 一錫村, 明生高柳, 哲也経頭蓋磁気刺激運動誘発電位日本リハビリテーション医学会2008-07-10T04:56:08Z2008-07-10T04:56:08Z1997-11-18ArticleJournal Article124016 bytesapplication/pdfリハビリテーション医学 Vol.34 No.11 p.762188135260034351Xhttp://hdl.handle.net/10564/31018813526AN00250275リハビリテーション医学3411762762jpnhttp://ci.nii.ac.jp/naid/110001863300/日本リハビリテーション医学会本文データは学協会の許諾に基づきCiNiiから複製したものであるpublisher
oai:ginmu.naramed-u.ac.jp:10564/3112017-06-11T23:20:26Zhdl_10564_21運動誘発電位と神経伝導検査による頸部神経根障害の検討(電気診断)田丸, 司市川, 昌平上野, 聡運動誘発電位神経伝導検査頸部神経根障害電気診断日本リハビリテーション医学会2008-07-10T05:27:09Z2008-07-10T05:27:09Z2002-04-18ArticleJournal Article84534 bytesapplication/pdfリハビリテーション医学 Vol.39 Suppl. p.S298188135260034351Xhttp://hdl.handle.net/10564/31118813526AN00250275リハビリテーション医学39Suppl.S298S298jpnhttp://ci.nii.ac.jp/naid/110001850702/日本リハビリテーション医学会本文データは学協会の許諾に基づきCiNiiから複製したものであるpublisher
oai:ginmu.naramed-u.ac.jp:10564/3122017-06-11T23:20:26Zhdl_10564_21脳幹脳炎に迷走神経麻痺による洞機能不全症候群と起立性頻脈症候群をきたした一例(その他の脳疾患・脳炎,リハビリテーション,ポスター,一般演題,実学としてのリハビリテーションの継承と発展,第44回日本リハビリテーション医学会学術集会)谷掛, 万里脳幹脳炎迷走神経麻痺洞機能不全症候群起立性頻脈症候群脳疾患日本リハビリテーション医学会2008-07-10T06:51:39Z2008-07-10T06:51:39Z2007-05-18ArticleJournal Article84534 bytesapplication/pdfリハビリテーション医学 Vol.44 Suppl. p.S382188135260034351Xhttp://hdl.handle.net/10564/31218813526AN00250275リハビリテーション医学44Suppl.S382S382jpnhttp://ci.nii.ac.jp/naid/110006450975/日本リハビリテーション医学会本文データは学協会の許諾に基づきCiNiiから複製したものであるpublisher
oai:ginmu.naramed-u.ac.jp:10564/3132017-06-11T23:20:26Zhdl_10564_21排便後に脊髄梗塞を生じた一例(脊髄損傷および脊髄疾患・症例1,ポスター,一般演題,実学としてのリハビリテーションの継承と発展,第44回日本リハビリテーション医学会学術集会)谷掛, 万里排便脊髄梗塞脊髄損傷脊髄疾患日本リハビリテーション医学会2008-07-10T07:16:20Z2008-07-10T07:16:20Z2007-05-18ArticleJournal Article81589 bytesapplication/pdfリハビリテーション医学 Vol.44 Suppl. p.S403188135260034351Xhttp://hdl.handle.net/10564/31318813526AN00250275リハビリテーション医学44Suppl.S403S403jpnhttp://ci.nii.ac.jp/naid/110006451027/日本リハビリテーション医学会本文データは学協会の許諾に基づきCiNiiから複製したものであるpublisher
oai:ginmu.naramed-u.ac.jp:10564/3332017-06-11T23:20:26Zhdl_10564_21外傷性側頭葉てんかん難治例に対するAmygdalohippocampectomy森本, 哲也江口, 隆彦中瀬, 裕之多田, 隆興榊, 寿右京井, 喜久男内海, 庄三郎外傷性側頭葉てんかんAmygdalohippocampectomy日本てんかん学会2008-07-11T03:19:34Z2008-07-11T03:19:34Z1990-11-16ArticleJournal Article112604 bytesapplication/pdf日本てんかん学会プログラム・抄録集 24回 p.98http://hdl.handle.net/10564/333AA11832791日本てんかん学会プログラム・抄録集249898jpnhttp://ci.nii.ac.jp/naid/110002669510/日本てんかん学会本文データは学協会の許諾に基づきCiNiiから複製したものであるpublisher
oai:ginmu.naramed-u.ac.jp:10564/3342017-06-11T23:20:26Zhdl_10564_21Mongolian jerbilにおける扁桃核電気刺激の検討江口, 隆彦多田, 隆興中瀬, 裕之平林, 秀裕榊, 寿右Mongolian jerbil扁桃核電気刺激日本てんかん学会2008-07-15T05:16:22Z2008-07-15T05:16:22Z1990-11-16ArticleJournal Article104042 bytesapplication/pdf日本てんかん学会プログラム・抄録集 24回 p.135http://hdl.handle.net/10564/334AA11832791日本てんかん学会プログラム・抄録集24135135jpnhttp://ci.nii.ac.jp/naid/110002669582/日本てんかん学会本文データは学協会の許諾に基づきCiNiiから複製したものであるpublisher
oai:ginmu.naramed-u.ac.jp:10564/3352017-06-11T23:20:26Zhdl_10564_21両側性周期性同期性放電(PSD)および多彩な脳波所見を呈したてんかんの1症例岩坂, 英巳飯田, 順三織部, 裕明平岡, 幸栄平尾, 文雄井川, 玄朗両側性周期性同期性放電PSD日本てんかん学会2008-07-16T01:09:23Z2008-07-16T01:09:23Z1990-11-16ArticleJournal Article103273 bytesapplication/pdf日本てんかん学会プログラム・抄録集 24回 p.228http://hdl.handle.net/10564/335AA11832791日本てんかん学会プログラム・抄録集24228228jpnhttp://ci.nii.ac.jp/naid/110002669765/日本てんかん学会本文データは学協会の許諾に基づきCiNiiから複製したものであるpublisher
oai:ginmu.naramed-u.ac.jp:10564/3362017-06-11T23:20:26Zhdl_10564_21ネブライザの微生物汚染防止と適正試用法Microbial Decontamination of Nebulizers and Their Proper Use勝井, 則明真鍋, 美智子喜多, 英二ネブライザ微生物汚染適正試用法Nebulizers have been recognized as potential agents of nosocomial respiratory infection. In this study, ultrasonic and jet nebulizers were evaluated for their relative hazard as measured by the concentration of bacterial output delivered with the aerosol and the contaminant counts of components of the nebulizers. Reservoirs were seeded with a tracer organism Pseudomonas fluorescens (~10^6 CFU/ml) in distilled water. Results indicate that the jet nebulizer produces heavily contaminated bacterial aerosols (uncountable colonies in the 10sec sampling period), whereas the ultrasonic nebulizer produces 135 CFU/plate in the 60sec. The contaminant counts of components of the jet nebulizer were 10^2~10^3 times higher than those of the ultrasonic nebulizer. When the contaminated corrugated and nasal tubes were used, the contaminants stayed on those tubes. And the use of the contaminated airfilter also gave identical results. The contamination due to the flow backwards of snivel or saliva from a nasal tube or a mouthpiece was protected by the back-flow valve. No viable organisms were detected in every component of the nebulizers after the disinfection with 0.1% Tego 51 for 15 min at room temperature.日本医科器械学会2008-07-16T01:32:38Z2008-07-16T01:32:38Z2000-07-01ArticleJournal Article560631 bytesapplication/pdf医科器械学 Vol.70 No.7 p.311-3160385440Xhttp://hdl.handle.net/10564/3360385440XAN00013123医科器械学707311316jpnhttp://ci.nii.ac.jp/naid/110002515217/日本医科器械学会本文データは学協会の許諾に基づきCiNiiから複製したものであるpublisher
oai:ginmu.naramed-u.ac.jp:10564/3372017-06-11T23:20:26Zhdl_10564_21371. 1km歩行による膝伸展筋の筋活運動量の変化について : 大腿直筋・外側広筋・内側広筋の筋持久性における一考察貝谷, 誠久大西, 竜哉弘本, 律子田中, 秀和生駒, 一憲歩行筋持久力筋活動日本理学療法士協会2008-07-16T02:16:06Z2008-07-16T02:16:06Z1998-04-20ArticleJournal Article163586 bytesapplication/pdf理学療法学 Vol.25 Suppl. p.37102893770http://hdl.handle.net/10564/33702893770AN10146032理学療法学25Suppl.371371jpnhttp://ci.nii.ac.jp/naid/10016490329/日本理学療法士協会本文データは学協会の許諾に基づきCiNiiから複製したものであるpublisher
oai:ginmu.naramed-u.ac.jp:10564/3382017-06-11T23:20:26Zhdl_10564_21けいれん発作発現機序に関与する興奮性アミノ酸中瀬, 裕之多田, 隆興江口, 隆彦平林, 秀裕榊, 寿右けいれん発作興奮性アミノ酸日本てんかん学会2008-07-16T23:57:31Z2008-07-16T23:57:31Z1990-11-16ArticleJournal Article110669 bytesapplication/pdf日本てんかん学会プログラム・抄録集 24回 p.234http://hdl.handle.net/10564/338AA11832791日本てんかん学会プログラム・抄録集24234234jpnhttp://ci.nii.ac.jp/naid/110002669777/日本てんかん学会本文データは学協会の許諾に基づきCiNiiから複製したものであるpublisher
oai:ginmu.naramed-u.ac.jp:10564/3392017-06-11T23:20:26Zhdl_10564_21乳癌サーモグラムの解析(第6回 日本医用サーモグラフィ研究会記録(II))太居, 英夫三木, 吉治乳癌サーモグラム日本医科器械学会2008-07-17T00:18:00Z2008-07-17T00:18:00Z1974-12-01ArticleJournal Article164339 bytesapplication/pdf醫科器械學雜誌 Vol.44 No.12 p.654-65500191736http://hdl.handle.net/10564/33900191736AN00013145醫科器械學雜誌4412654655jpnhttp://ci.nii.ac.jp/naid/110002530652/日本医科器械学会本文データは学協会の許諾に基づきCiNiiから複製したものであるpublisher
oai:ginmu.naramed-u.ac.jp:10564/3402017-06-11T23:20:26Zhdl_10564_21Skeletal Extension(半埋め込み型人工四肢)富田, 直秀Skeletal Extension人工四肢日本機械学会2008-07-17T00:37:23Z2008-07-17T00:37:23Z1990-12-05ArticleJournal Article93794 bytesapplication/pdf日本機械学會誌 Vol.93 No.865 p.99600214728http://hdl.handle.net/10564/34000214728AN00187394日本機械学會誌93865996996jpnhttp://ci.nii.ac.jp/naid/110002436748/日本機械学会本文データは学協会の許諾に基づきCiNiiから複製したものであるpublisher
oai:ginmu.naramed-u.ac.jp:10564/3412017-06-11T23:20:26Zhdl_10564_21脊髄小脳変性症のリハビリテーション真野, 行生小脳疾患脊髄疾患脊髄小脳変性症リハビリテーション日本理学療法士協会2008-07-17T00:48:49Z2008-07-17T00:48:49Z1983-06-25ArticleJournal Article872639 bytesapplication/pdf臨床理学療法 Vol.10 No.2 p.88-9602870827http://hdl.handle.net/10564/34102870827AN00254061臨床理学療法1028896jpnhttp://ci.nii.ac.jp/naid/110004004275/日本理学療法士協会本文データは学協会の許諾に基づきCiNiiから複製したものであるpublisher
oai:ginmu.naramed-u.ac.jp:10564/3422017-06-11T23:20:26Zhdl_10564_21MSA(Multiple System Atrophy)に対する理学療法について天野, 三郎寺本, 純榊原, 敏正真野, 行生Shy-Drager症候群MSA(Multiple System Atrophy)理学療法日本理学療法士協会2008-07-17T00:55:41Z2008-07-17T00:55:41Z1983-10-25ArticleJournal Article89643 bytesapplication/pdf臨床理学療法 Vol.10 No.4 p.19802870827http://hdl.handle.net/10564/34202870827AN00254061臨床理学療法104198198jpnhttp://ci.nii.ac.jp/naid/110003999767/日本理学療法士協会本文データは学協会の許諾に基づきCiNiiから複製したものであるpublisher
oai:ginmu.naramed-u.ac.jp:10564/3432017-06-11T23:20:26Zhdl_10564_21スモン後遺症の基本的動作について : 臨床所見との対比天野, 三郎真野, 行生北岡, 俊二門脇, 明仁安間, 治川村, 邦男SMONスモン後遺症基本的動作日本理学療法士協会2008-07-17T01:01:37Z2008-07-17T01:01:37Z1983-10-25ArticleJournal Article89643 bytesapplication/pdf臨床理学療法 Vol.10 No.4 p.19802870827http://hdl.handle.net/10564/34302870827AN00254061臨床理学療法104198198jpnhttp://ci.nii.ac.jp/naid/110003999768/日本理学療法士協会本文データは学協会の許諾に基づきCiNiiから複製したものであるpublisher
oai:ginmu.naramed-u.ac.jp:10564/5532017-06-11T23:20:26Zhdl_10564_21痙攣発作発現機序に関する基礎的研究 : 痙攣発作前後の興奮性アミノ酸の変動中瀬, 裕之江口, 隆彦平林, 秀裕森本, 哲也多田, 隆興榊, 寿右痙攣発作アミノ酸日本てんかん学会2008-11-04T02:02:03Z2008-11-04T02:02:03Z1991-10-04ArticleJournal Article112443 bytesapplication/pdf日本てんかん学会プログラム・抄録集 25回 p.95http://hdl.handle.net/10564/553AA11832791日本てんかん学会プログラム・抄録集259595jpnhttp://ci.nii.ac.jp/naid/110002669796/日本てんかん学会本文データは学協会の許諾に基づきCiNiiから複製したものであるpublisher
oai:ginmu.naramed-u.ac.jp:10564/5542017-06-11T23:20:26Zhdl_10564_21痙攣重積状態における頭蓋内圧と脳循環動態江口, 隆彦中瀬, 裕之辻本, 正三郎星田, 徹森本, 哲也角田, 茂榊, 寿右痙攣重積状態頭蓋内圧脳循環動態日本てんかん学会2008-11-04T02:18:32Z2008-11-04T02:18:32Z1991-10-04ArticleJournal Article92272 bytesapplication/pdf日本てんかん学会プログラム・抄録集 25回 p.202http://hdl.handle.net/10564/554AA11832791日本てんかん学会プログラム・抄録集25202202jpnhttp://ci.nii.ac.jp/naid/110002669973/日本てんかん学会本文データは学協会の許諾に基づきCiNiiから複製したものであるpublisher
oai:ginmu.naramed-u.ac.jp:10564/5552017-06-11T23:20:26Zhdl_10564_21腹部大動脈置換術後の後腹膜腔乳糜貯留に対するリンパ管結紮術の1治験例Successful Surgical Treatment of Retroperitoneal Lymphocele after an Abdominal Aortic Aneurysm Repair桒田, 俊之多林, 伸起川田, 哲嗣阿部, 毅寿上田, 高士谷口, 繁樹腹部大動脈瘤人工血管置換術乳糜貯留リンパ管結紮術腹部大動脈置換術後,非常に希な合併症である乳糜貯留を認め,外科的治療で治癒しえたので報告する.症例は70歳男性.最大径5cmの腎動脈下腹部大動脈瘤に対して,左後腹膜アプローチによる人工血管置換術を施行した.術後17日目より腹部膨満感と発熱が出現し,CTにて後腹膜腔に液体の貯留を認めたため,経皮的ドレナージ術を施行した.細菌培養が陰性で,脂肪滴が存在する乳白色の排液を得たため,乳糜貯留と診断した.絶食,IVH,ドレナージの保存的療法で加療したが,排液の減少が認められないため,リンパ管結紮術を施行した.術直後より乳糜は完全に消失し,軽快退院した.Retroperitoneal lymphocele is a very rare complication of abdominal aortic aneurysm repair. An abdominal aortic aneurysm 5 cm in diameter was repaired with the retroperitoneal approach in a 70-year-old man. On the 17th postoperative day, mild abdominal distention was reported and a fever of 38℃ had developed. A computed tomography scan demonstrated massive fluid collection in the retroperitoneal cavity. Total parenteral nutrition with complete fasting was initiated. A pigtail catheter was inserted into the cavity, and 1,000 ml of milky, odorless, alkaline and sterile fluid was drained. Subsequently, a retroperitoneal lymphocele following abdominal aortic surgery was diagnosed. The leaking lymph tract was ligated because the lymphocele did not improve with long term drainage. Administration of ice cream through the nasogastric tube was used to detect the leaking lymph tract, and we ligated the leaking lymph tract completely. We believe that surgical repair is an alternative strategy when conservative treatments, i. e., fasting, intravenous hyperallimentation and drainage are not effective.日本心臓血管外科学会2008-11-04T02:36:05Z2008-11-04T02:36:05Z2002-05-15ArticleJournal Article513487 bytesapplication/pdf日本心臓血管外科学会雑誌 Vol.31 No.3 p.224-22602851474http://hdl.handle.net/10564/55502851474AN00193284日本心臓血管外科学会雑誌313224226jpnhttp://ci.nii.ac.jp/naid/110004000530/日本心臓血管外科学会本文データは学協会の許諾に基づきCiNiiから複製したものであるpublisher
oai:ginmu.naramed-u.ac.jp:10564/5562017-06-11T23:20:26Zhdl_10564_21心大血管術後の呼吸不全に対する非侵襲的陽圧換気法(NIPPV)の使用経験Noninvasive Possitive Pressure Ventilation (NIPPV) for Patients with Acute Respiratory Failure after Cardiovascular Surgery内藤, 洋川田, 哲嗣坂口, 秀仁多林, 伸起上田, 高士平井, 勝治福岡, 篤彦谷口, 繁樹NIPPV術後呼吸不全COPD心大血管術後の呼吸不全に対して,挿管することなくマスクを用いて陽圧換気を行う非侵襲的陽圧換気法(NIPPV)を施行し,良好な結果を得た.症例1:63歳,男性.COPDを合併した弓部大動脈瘤に対して人工血管置換術を施行した.術後5日目に抜管したが,COPDの急性増悪のため,再挿管となった.抜管後の呼吸補助を目的に,術後14日目にNIPPVを開始した.徐々に圧補助を減らし,18日目にNIPPVから離脱しえた.症例2:67歳,男性.狭心症に対して冠状動脈バイパス術を施行した.術翌日に抜管したが,3日目に無気肺による低酸素血症となった.高濃度酸素投与および持続陽圧呼吸目的にNIPPVを開始した.速やかに症状の改善を認め,術後7日目にNIPPVから離脱しえた.NIPPVは心大血管術後の呼吸不全に対して有用であり,積極的に試みてもよいと思われた.NIPPV provides positive pressure ventilation through a face mask without intubation. We performed NIPPV for 2 patients with acute respiratory failure following cardiovascular surgery. (Case 1) A 63-year-old man, who had had COPD (Hugh-Jones class III), underwent replacement of the aortic arch. He was extubated after 5 days. However, he was re-intubated under controlled ventilation because of deterioration of his respiratory condition. The patient had NIPPV after cxtubation on postoperative day 14 because he was alert and had no cardiovascular compromise. On the 18th postoperative day he was weaned from NIPPV. (Case 2) A 67-year-old man underwent coronary artery bypass surgery. On the next day he was extubated, but he suffered from hypoxemia due to impaired respiratory condition on postoperative day 3. The patient underwent NIPPV instead of conventional mechanical ventilation because his condition was stable except for respiration. Respiratory condition improved quickly and he was weaned from NIPPV on the 7th postoperative day. NIPPV is an effective method for managing patients with acute respiratory failure after cardiovascular surgery.日本心臓血管外科学会2008-11-04T03:01:39Z2008-11-04T03:01:39Z2003-03-15ArticleJournal Article1264943 bytesapplication/pdf日本心臓血管外科学会雑誌 Vol.32 No.2 p.94-9702851474http://hdl.handle.net/10564/55602851474AN00193284日本心臓血管外科学会雑誌3229497jpnhttp://ci.nii.ac.jp/naid/110003992822/日本心臓血管外科学会本文データは学協会の許諾に基づきCiNiiから複製したものであるpublisher
oai:ginmu.naramed-u.ac.jp:10564/5572017-06-11T23:20:26Zhdl_10564_21Lateral MIDCABを用いた再冠状動脈バイパス術 : Graft,inflow,およびgraft経路の選択における工夫Redo CABG Using Lateral Minimally Invasive Direct Coronary Artery Bypass Technique : Selection of Grafts, Bypass Inflow and Bypass Routes早田, 義宏川田, 哲嗣坂口, 秀仁多林, 伸起吉川, 義朗長阪, 重雄上田, 高士阿部, 毅寿森田, 耕三谷口, 繁樹lateral MIDCAB再冠状動脈バイパス術冠状動脈バイパス術後遠隔期に回旋枝領域の虚血が出現した3症例に対し,左開胸心拍動下冠状動脈バイパス術(lateral MIDCAB)を用いて再冠状動脈バイパス術を行い良好な結果を得たので報告する.症例1)52歳男性,初回手術後11年目に狭心症が再発した.胸部下行大動脈をinflowとして肺門下経路を通した橈骨動脈(RA)を用いて,後側壁枝(PL)と鈍縁枝(OM)にsequential bypassを行った.症例2)67歳男性,初回手術後7年目に狭心症が再発した.RAでT-composite srraftを作製し,胸部下行大動脈をinflowとして肺門下経路を通してPLとOMの血行再建を行った.症例3)69歳男性,初回手術後10年目に狭心症が再発した.胸部下行大動脈に全長にわたる高度石灰化を認めたため,左腋窩動脈をinflowとして大伏在静脈(SVG)を肺門前経路を通し,開存していたSVG-PLバイパスヘ端側吻合した.回旋枝領域への再冠状動脈バイパス術を行う場合に,lateral MIDCABは非常に有用であるが,graftやgraft経路,inflowの選択には工夫を要すると考えられる.We performed redo coronary artery bypass grafting (CABG) using lateral MIDCAB for 3 patients with severe symptomatic ischemia in the left circumflex system alone. When the descending thoracic aorta had no atherosclerotic lesions on chest CT, it was selected as the inflow of the bypass. According to the location of the target artery, we undertook sequential or T-composite off-pump bypass using the radial artery through a left lateral thoracotomy. On the other hand, when the descending aorta was diseased, the left axillary artery was chosen as the inflow of the bypass. We selected the saphenous vein as a conduit to obtain sufficient graft length. A proximal anastomosis was made through a left infraclavicular incision, and then a distal anastomosis was done through a left lateral thoracotomy without cardiopulmonary bypass. Moreover, care was taken not to kink the grafts. The postoperative course was uneventful in all patients. Lateral MIDCAB technique was useful for redo revascularization to the circumflex system. We believe that selection of bypass conduits, routes, and bypass inflow according to the individual patient is essential for the procedure.日本心臓血管外科学会2008-11-04T05:41:50Z2008-11-04T05:41:50Z2003-09-15ArticleJournal Article1124972 bytesapplication/pdf日本心臓血管外科学会雑誌 Vol.50 No.5 p.318-32102851474http://hdl.handle.net/10564/55702851474AN00193284日本心臓血管外科学会雑誌505318321jpnhttp://ci.nii.ac.jp/naid/110003992877/日本心臓血管外科学会本文データは学協会の許諾に基づきCiNiiから複製したものであるpublisher
oai:ginmu.naramed-u.ac.jp:10564/7772017-05-29T06:06:31Zhdl_10564_21hdl_10564_2599腎移植患者17例における血中サイトメガロウイルスのPCRによる検出とその臨床的意義PCR-detection of Cytomegalovirus in 17 Patients with Renal Transplantation松本, 雅則藤村, 吉博辻内, 智美島, 正幸下山, 丈人成田, 亘啓小林, 恵子吉田, 佳嗣谷口, 繁樹北村, 惣一郎米田, 龍生平尾, 佳彦吉田, 克法岡島, 英五郎Renal transplantationCMVPCR著作権者:日本移植学会日本移植学会2009-02-12T01:00:34Z2009-02-12T01:00:34Z1995-10-10ArticleJournal Article3582237 bytesapplication/pdf移植 Vol.30 No.3 p.464-47105787947http://hdl.handle.net/10564/77705787947AN00014749移植305464471jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/9082017-06-11T23:20:26Zhdl_10564_21What is the Critical Hyperthermia Target in Cancer Cells?Takahashi, AkihisaOhnishi, Takeohyperthermiacell killingprotein denaturationγH2AXdouble-strand breakCurrently, the molecular mechanisms involved in heat-induced cell killing are not completely understood, although protein denaturation is known to be the major target for hyperthermia in cancer cells. A new hypothesis is described here which proposes that heat-induced cell killing is associated with cellular DNA double-strand break (DSB) formation. This review provides details of this model for hyperthermia cell killing, and a possible mechanism to explain heat-induced DSB formation.著作権者:日本ハイパーサーミア学会日本ハイパーサーミア学会及び著作者の許諾を得て登録日本ハイパーサーミア学会2009-11-26T03:17:25Z2009-11-26T03:17:25Z2006ArticleJournal Article685348 bytesapplication/pdf日本ハイパーサーミア学会誌 = Japanese journal of hyperthermic oncology Vol. 22 (2006) , No. 4 pp.229-23709112529http://hdl.handle.net/10564/90809112529AN10084762日本ハイパーサーミア学会誌 = Japanese journal of hyperthermic oncology224229237enghttp://www.jstage.jst.go.jp/article/thermalmedicine/22/4/229/_pdfhttp://www.jsho.jp/publisher
oai:ginmu.naramed-u.ac.jp:10564/9092017-06-11T23:20:26Zhdl_10564_21The Biology of Heat-induced DNA Double-Strand BreaksMori, EiichiroTakahashi, AkihisaOhnishi, TakeohyperthermiaDNA double-strand breakγH2AXendogenous DNA damageHyperthermia is widely used to treat patients with various types of cancers. However, the molecular mechanisms involved in heat-induced cell killing are not yet fully understood. Although protein denaturation is known to be a major type of damage caused by heat treatment, recent work has revealed that DNA double-strand breaks (DSBs) play important roles in heat-induced cell killing. The aim of this review is to specifically examine the formation and repair of DSBs and their role in heat sensitivity and thermotolerance.著作権者:日本ハイパーサーミア学会日本ハイパーサーミア学会及び著作者の許諾を得て登録日本ハイパーサーミア学会2009-11-26T05:05:32Z2009-11-26T05:05:32Z2006ArticleJournal Article379027 bytesapplication/pdfThermal Medicine Vol. 24 (2008) , No. 2 pp.39-5009112529http://hdl.handle.net/10564/90909112529AN10084762日本ハイパーサーミア学会誌 = Thermal medicine2423950enghttp://www.jstage.jst.go.jp/article/thermalmed/24/2/39/_pdfhttp://www.jsho.jp/publisher
oai:ginmu.naramed-u.ac.jp:10564/9102017-06-11T23:20:26Zhdl_10564_21Heat-induced Signal Transduction Pathways Leading to Cell Death and Cell Survival in Cancer CellsKajihara, AtsuhisaTakahashi, AkihisaOhnishi, Takeosignal transductioncell deathcell survivalprotein microarrayheatIn recent years, cancer therapy research has focused on molecular targets. For efficient hyperthermic cancer therapy, potential targets of interest are molecules which respond to heat and selectively activate signal transduction factors which can inhibit cancer cell proliferation. Signal transduction pathways affected by heat include p53 mediated pathways, JNK (Jun N-terminal kinase) mediated pathways, Akt (protein kinase B) mediated pathways, NBS1 (Nijimegen breakage syndrome 1) mediated pathways, classic MAP (mitogen activated protein) kinase mediated pathways, and p38 MAP kinase mediated pathways. Events such as cell death, cell survival, cell proliferation, and/or cell cycle arrest can be affected by these pathways. To learn more about heat-induced gene and protein expression, cDNA arrays and protein microarrays were used to study cellular responses to heat. This paper briefly reviews interactions of pro- and anti-apoptotic genes and proteins which are induced by heat shock and are components of signal transduction pathways.著作権者:日本ハイパーサーミア学会日本ハイパーサーミア学会及び著作者の許諾を得て登録日本ハイパーサーミア学会2009-11-26T05:16:24Z2009-11-26T05:16:24Z2006ArticleJournal Article1271909 bytesapplication/pdfThermal Medicine Vol. 25 (2009) , No. 1 pp.1-1109112529http://hdl.handle.net/10564/91009112529AN10084762日本ハイパーサーミア学会誌 = Thermal Medicine251111enghttp://www.jstage.jst.go.jp/article/thermalmed/25/1/1/_pdfhttp://www.jsho.jp/publisher
oai:ginmu.naramed-u.ac.jp:10564/9112017-06-11T23:20:26Zhdl_10564_21A Priming Heat Treatment Can Induce the Development of Heat- and Radio-resistance via HSPs, Regardless of p53-gene StatusTakahashi, AkihisaOhnishi, Takeoheat-resistanceradio-resistanceHSPp53NOIt has been suggested that inducible heat shock proteins (HSPs) may function in multiple roles in cytoprotection. However, recent reports have shown that nitric oxide (NO) radicals are an initiator of heat- and radio-resistance, and act through the activation of the human homolog of MDM2 (HDM2), the depression of p53 accumulation, and the induction of NO synthase (iNOS, or alternatively, NOS2) which is observed following a priming irradiation. The aim of this work was to acquire additional information on the roles of p53, HDM2, iNOS, NO radicals, and HSPs on the development of heat- and radio-resistance as following a priming heat treatment. Wild-type (wt) p53 and mutated (m) p53 cells were used. These cells were derived from the H1299 human lung cancer cell line in which p53 is deleted. Cellular sensitivities were determined with a colony-forming assay. In both pre-heated wtp53 cells and in pre-heated mp53 cells, the induction of heat- and radio-resistance was observed in the absence of KNK437 (an inhibitor of HSPs), and in the presence of RITA (an inhibitor of p53-HDM2 interactions), aminoguanidine (an iNOS inhibitor) or c-PTIO (an NO radical scavenger). These findings suggest that following a priming heat treatment, HSPs contribute to heat- and radio-resistance.著作権者:日本ハイパーサーミア学会日本ハイパーサーミア学会及び著作者の許諾を得て登録日本ハイパーサーミア学会2009-11-26T05:26:31Z2009-11-26T05:26:31Z2006ArticleJournal Article251822 bytesapplication/pdfThermal Medicine Vol. 25 (2009) , No. 1 pp.13-2309112529http://hdl.handle.net/10564/91109112529AN10084762日本ハイパーサーミア学会誌 = Thermal Medicine2531323enghttp://www.jstage.jst.go.jp/article/thermalmed/25/1/13/_pdfhttp://www.jsho.jppublisher
oai:ginmu.naramed-u.ac.jp:10564/9122017-06-11T23:20:26Zhdl_10564_21Restraint Plus Water-immersion Stress (RWIS)-induced Stomach Ulcers in Mice are Depressed by a Conditioning Heat TreatmentYamagata, RikioTakahashi, AkihisaSu, XiaomingMorimoto, TomokoOhnishi, Takeoheat stressrestraint plus water-immersion stress (RWIS)stomach ulcerapoptosisadaptive responseA conditioning mild heat treatment can depress subsequent severe heat-induced biological damage by inducing thermal tolerance. In the work described here, the effect of a conditioning mild heat exposure at 37°C was examined on the formation of gastric mucosa damage induced by a restraint plus water-immersion stress (RWIS) treatment in mice. RWIS treatments induced stomach ulcers in about 42% of the control animals, but a mild conditioning heat treatment at 37°C was found to depress the appearance of ulcers, and only about 9% of the pre-exposed animals developed ulcers. In addition, RWIS treatment induced an apoptosis rate in the stomach of about 13%, but a conditioning mild heat treatment depressed the apoptotic rate to about 8%. Since the heat shock protein (HSP) inducer geranylgeranylacetone (GGA) also efficiently depressed stomach ulcer incidence rates, it is suggested that gastric mucosa damage may be depressed by HSPs induced by a mild conditioning heat treatment through the depression of apoptosis.著作権者:日本ハイパーサーミア学会日本ハイパーサーミア学会及び著作者の許諾を得て登録日本ハイパーサーミア学会2009-11-26T05:38:21Z2009-11-26T05:38:21Z2006ArticleJournal Article255214 bytesapplication/pdfThermal Medicine Vol. 25 (2009) , No. 3 pp.81-8709112529http://hdl.handle.net/10564/91209112529AN10084762日本ハイパーサーミア学会誌 = Thermal Medicine2538187enghttp://www.jstage.jst.go.jp/article/thermalmed/25/3/81/_pdfhttp://www.jsho.jp/publisher
oai:ginmu.naramed-u.ac.jp:10564/17432017-06-11T23:20:26Zhdl_10564_21hdl_10564_2599動脈血栓症の制圧 : VWF-GPIb軸依存性血小板血栓形成を調節するADAMTS13の基礎・臨床病態解析Control of arterial thrombosis: basic and clinical research on the VWF-GPIb axis-dependent thrombotic disorders, modulated by ADAMTS13藤村, 吉博松本, 雅則植村, 正人杉本, 充彦小亀, 浩市宮田, 敏行The mortality due to arterial thrombosis such as myocardial infarction and cerebral
infarction exceeds that of malignant neoplasm, is increasing further, and is also becoming a big social issue in our country. Currently, arterial thrombosis is assumed to be established in vivo under rheological conditions where blood flow creates high shear stress. Under such conditions, the von Willebrand factor (VWF)-platelet glycoprotein
(GP) Ib interaction plays a definitive role on platelet adhesion and aggregation that
could be a key event for the formation of arterial thrombosis. In this regard. the biological activity of VWF under high shear stress is absolutely dependent upon its unique multimeric structure, the size of which is thought to be precisely regulated in vivo by the recently identified specific VWF-cleaving protease (ADAMTS13). Thus, the aim of our research project is to overcome arterial thrombosis targeting the functional relationships between the VWF-GPIb axis and ADAMTS13 in platelet thrombus formation.
In the initial stage of our research, we have focused on the structure-function relationships of VWF. We have clarified the several functional sites within the VWF molecule critical for platelet thrornbus formation. In addition, our functional
studies of VWF using a perfusion chamber system that can reproduce physiologic blood flow in vitro elucidated the shear-dependent function of VWF in platelet adhesion and aggregation, as well as the molecular mechanisms of the VWF-GPIb axis regulation by ADAMTS13 under blood flow conditions. Thus, our results altogether contributed to extend our understandings of molecular mechanisms for the arterial thrombosis.
In the progressed stage of our research. our focus was shifted to the pathophysiology
of the ADAMTS13 molecule. In particular, analyzing the phenotype-genotype relationships of congenital deficiency of ADAMTS13, termed Upshaw-Schulman syndrome (USS), due to ADAMTS13 gene mutations, can provide in vivo prototypic model of platelet thrombus formation under high shear stress. But USS is an extremely rare disease or often masqueraded as an isolated thrombocytopenia with mild clinical signs during childhood. During the past 10 years, we have diagnosed 37 patients with USS by assaying ADAMTS13 activity and its inhibitor titers in the laboratory of Nara Medical University. Further, through analyzing the natural history and ADAMTS13 gene mutations in these patients, we found that severe neonatal jaundice that requires exchange blood transfusions, a classic hallmark of USS, was seen in only 16 (43%) of 37 patients. Twenty-nine (79%) of the 37 patients had a history of thrombocytopenia during childhood that was misdiagnosed as idiopathic thrombocytopenic purpura(ITP). Nine women from 6 families were first diagnosed during pregnancy. Further, we documented that thrombocytopenia inevitably developed during the 2nd or 3rd trimesters of all 16 pregnancies in these 9 women. Often the initial isolated thrombocytopenia was followed by overt signs of microangiopathic hemolytic anemia and thrombotic thrombocytopenic purpura (TTP). Notably, of their 16 pregnancies,8 infants were stillborn or died soon after birth; the remaining 8 were all premature but survived. Six of these 9 women had the episodes of severe-to-mild thrombocytopenia during childhood that had been incorrectly diagnosed as ITP. In extension of the abovementioned studies, we have identified that the following disorders including TTP are related to acquired deficiencies of ADAMTS13 activity with an appearance of UL-VWFM; brain infarction, renal insufficiency, habitual abortion, liver cirrhosis,liver transplantation, acute severe pancreatitis, hepatic ven←occlusive disease, cardiac infarction, and sleeping apnea syndrome. Thus, during the past few years, Copernican-like conversion has been made on the understanding these diseases. Evolution of new rapid assays evaluating ADAMTS13 activity developed by our research group certainly accelerated this. Further, the idea of contraindication for platelet transfusions to the patients with severe deficiency of ADAMTS13 activity has also been well established, because of confident observations on platelet hyperaggregability under high shear stress in the presence of UL-VWFM.第45回2008年度 ベルツ賞2等賞受賞論文この文献は著作者(共著者も含む)及び出版社(最新医学社、ベーリンガーインゲルハイム社)の許諾を得て掲載しております。最新医学社2011-11-11T06:03:25Z2011-11-11T06:03:25Z2009-02-10ArticleJournal Article5464064 bytesapplication/pdf最新医学 64巻2号(通巻第800号) p.290-321 (2009.02)03708241http://hdl.handle.net/10564/174303708241AN00094908最新医学642290321jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/17442017-06-11T23:20:26Zhdl_10564_21hdl_10564_2599Natural history of Upshaw-Schulman syndrome based on ADAMTS13 gene analysis in JapanFujimura, YoshihiroMatsumoto, MasanoriIsonishi, AyamiYagi, HideoKokame, KoichiSoejima, KenjiMurata, MitsuruMiyata, ToshiyukiADAMTS13 gene mutationclinical phenotypenatural historyUpshaw–Schulman syndromeUpshaw–Schulman syndrome (USS) is an extremely rare hereditary deficiency of ADAMTS13 activity, termed congenital TTP. The clinical signs are usually mild during childhood, often with isolated thrombocytopenia. But their symptoms become more evident when patients have infections or get pregnant. We identified 43 USS-patients in Japan, who ranged in age from early childhood to 79 years of age. Analysing the natural history of these USS patients based on ADAMTS13 gene mutations may help characterise their clinical phenotypes. Severe neonatal jaundice that requires exchange blood transfusion, a hallmark of USS, was found in 18 of 43 patients (42%). During childhood, 25 of 43 patients were correctly diagnosed with USS without gender disparity. These 25 patients were categorised as having ‘the early-onset phenotype’. Between 15 and 45 years of age, 15 were correctly diagnosed, and, interestingly, they were all female. The remaining three patients were male and were diagnosed when they were older than 45 years of age, suggesting that they were ‘the late-onset phenotype’. Two of these three males developed sudden overt TTP when they were 55 and 63 years old, respectively. These two men had two different homozygous ADAMTS13 gene mutations, p.R193W/p.R193W and p.C1024R/p.C1024R, respectively. Both of which were not discovered in the US or Western countries. In vitro expression studies showed that these two proteins were consistently secreted into the culture medium but to a lesser extent and with reduced activity compared to the wild-type protein. Our results indicate that ‘the late-onset phenotype’ of USS is formed with ethnic specificity.・The definitive version is available at " http://dx.doi.org/10.1111/j.1538-7836.2011.04341.x "・State of the Art 2011 : XXIII Congress of the International Society on Thrombosis and Haemostasis Invited Reviewhttp://dx.doi.org/10.1111/j.1538-7836.2011.04341.xBlackwell Pub LTD2011-12-04T06:54:54Z2011-12-04T06:54:54Z2011-07-22ArticleJournal Article6 bytestext/plainJournal of thrombosis and haemostasis Vol.9 Suppl. 1 p.283–30115387933http://hdl.handle.net/10564/174415387933AA11811179Journal of thrombosis and haemostasis9Suppl. 1283301enghttp://www.ncbi.nlm.nih.gov/pubmed/21781265http://dx.doi.org/10.1111/j.1538-7836.2011.04341.xauthor
oai:ginmu.naramed-u.ac.jp:10564/22742017-06-11T23:20:26Zhdl_10564_21痙攣重積状態における発作性異常高血圧に対する実験的検討江口, 隆彦中瀬, 裕之辻本, 正三郎星田, 徹森本, 哲也角田, 茂榊, 寿右日本てんかん学会2012-08-08T06:27:24Z2012-08-08T06:27:24Z1992-10-01ArticleJournal Article日本てんかん学会プログラム・予稿集 26回 p.122http://hdl.handle.net/10564/2274AA11832805日本てんかん学会プログラム・予稿集26122122jpnhttp://ci.nii.ac.jp/naid/110002670114/日本てんかん学会本文データは学協会の許諾に基づきCiNiiから複製したものであるpublisher
oai:ginmu.naramed-u.ac.jp:10564/22752017-06-11T23:20:26Zhdl_10564_21けいれん準備性獲得過程に関する基礎的研究 : 発作発現域値と後発射持続時間の変動中瀬, 裕之江口, 隆彦平林, 秀裕森本, 哲也多田, 隆興榊, 寿右日本てんかん学会2012-08-08T06:34:39Z2012-08-08T06:34:39Z1992-10-01ArticleJournal Article日本てんかん学会プログラム・予稿集http://hdl.handle.net/10564/2275AA11832805日本てんかん学会プログラム・予稿集26152152jpnhttp://ci.nii.ac.jp/naid/110002670173/日本てんかん学会本文データは学協会の許諾に基づきCiNiiから複製したものであるpublisher
oai:ginmu.naramed-u.ac.jp:10564/22762017-06-11T23:20:26Zhdl_10564_21Nocturnal hypoxic stress activates invasive ability of monocytes in patients with obstructive sleep apnea syndromeTamaki, ShinjiYamauchi, MotooFukuoka, AtsuhikoMakinodan, KiyoshiKoyama, NorikoTomoda, KoichiYoshikawa, MasanoriKimura, Hiroshiatherosclerosishypoxiamonocytesleep apnoeaBackgrounds: Obstructive sleep apnea syndrome (OSAS) is known to be a risk factor of cardiovascular events. However, the precise mechanism has not been fully elucidated. OSAS-induced hypoxic stress may promote the production of inflammatory cytokines and chemokines by monocytes, which has a crucial role in the development of atherosclerosis. In addition, adhesion to the vascular endothelium and transendothelial migration of monocytes are considered to induce atherosclerosis. The aim of this study was to investigate the effects of hypoxic stress on the invasive ability of monocytes in OSAS.
Methods; Twenty-one male OSAS patients and 17 male healthy control subjects, age- and body mass index-matched, were enrolled. Venous blood samples were collected not only before and after sleep but also after CPAP titration for the purpose of monocyte isolation. The invasive ability of monocytes was evaluated by counting the number of invasive cells using a BD BioCoat Matrigel Invasion Chamber.
Results; The number of cells which represents invasive ability was significantly higher in OSAS patients as compared to control subjects in the early morning (p<0.001). Invasive ability in the early morning was significantly elevated as compared to that before sleep in OSAS patients (p<0.001), and it was positively correlated with oxygen desaturation index (p<0.05). CPAP titration led to alleviation of the invasive ability (p<0.001).
Conclusions; The results indicate that OSAS-induced hypoxic stress activates the invasive ability of monocytes, and that this phenomenon observed during sleep may contribute to the development of atherosclerosis in OSAS.The definitive version is available at " http://dx.doi.org/10.1111/j.1440-1843.2009.01540.x "アジア太平洋呼吸器学会(APSR:Asia Pacific Society of Respirology)第1回最優秀論文賞「Fukuchi Award」受賞論文WILEY-BLACKWELL PUBLISHING, INC2012-08-08T08:18:29Z2012-08-08T08:18:29Z2009-07ArticleJournal ArticleRespirology Vol.14 No.5 pp.689-6941323-7799http://hdl.handle.net/10564/22761323-7799AA11097269Respirology145689694enghttp://www.ncbi.nlm.nih.gov/pubmed/19476600http://dx.doi.org/10.1111/j.1440-1843.2009.01540.xauthor
oai:ginmu.naramed-u.ac.jp:10564/23202017-06-11T23:20:26Zhdl_10564_21Combination of Interferon-β and the Angiotensin-Converting Enzyme Inhibitor, Perindopril, Attenuates Murine Hepatocellular Carcinoma Development and Angiogenesis.Noguchi, RyuichiYoshiji, HitoshiKuriyama, ShigekiYoshii, JunichiIkenaka, YasuhideYanase, KojiNamisaki, TadashiKitade, MitsuteruYamazaki, MasaharuMitoro, AkiraTsujinoue, HirohisaImazu, HirooMasaki, TsutomuFukui, HiroshiVEGFangiogenesisACE inhibitorinterferonHCCPURPOSE: Angiogenesis is now recognized as a crucial step in the development of tumors, including hepatocellular carcinoma (HCC). The aim of this study was to elucidate the combined effect of the clinically used angiotensin I-converting enzyme (ACE) inhibitor, perindopril (PE), and IFN-beta on the development and angiogenesis of murine HCC at clinically comparable low doses.
EXPERIMENTAL DESIGN: PE and IFN were administered at doses of 2 mg/kg/day and 1 x 10(4) IU/twice a week, respectively.
RESULTS: Both PE and IFN significantly suppressed HCC development and inhibited neovascularization in the tumor, although the effect of low-dose IFN was weaker than that of PE. A combination regimen of PE plus IFN was effective; IFN significantly augmented the tumoricidal effect of PE. These inhibitory effects of PE plus IFN could be detected even on established tumors. The potent angiogenic factor, vascular endothelial growth factor, was markedly suppressed by combined treatment with PE and IFN, whereas these agents produced a marked increase of apoptosis in the tumor. The in vitro studies exhibited that PE and IFN inhibited endothelial cell tubular formation. IFN also suppressed endothelial cell proliferation, whereas neither IFN nor PE showed any inhibitory effect on proliferation of HCC cells.
CONCLUSION: The combination treatment of PE and IFN at clinically comparable low doses could inhibit HCC development and angiogenesis and suppress vascular endothelial growth factor as well. Because both agents are widely used in clinical practice, this combination regimen may represent a potential new strategy for HCC therapy in the future.The definitive version is available at " http://clincancerres.aacrjournals.org/content/9/16/6038 "American Association for Cancer Research2012-10-25T06:20:33Z2012-10-25T06:20:33Z2003-12-01ArticleJournal ArticleClinical Cancer Research Vol.9 No.16 pp.6038–604510780432http://hdl.handle.net/10564/232010780432AA11029881Clinical Cancer Research91660386045enghttp://www.ncbi.nlm.nih.gov/pubmed/14676130author
oai:ginmu.naramed-u.ac.jp:10564/23212017-06-11T23:20:26Zhdl_10564_21Different tumoricidal effects of interferon subclasses and p53 status on hepatocellular carcinoma development and neovascularization.Noguchi, RyuichiYoshiji, HitoshiIkenaka, YasuhideKitade, MitsuteruKaji, KosukeYoshii, JunichiYanase, KojiNamisaki, TadashiYamazaki, MasaharuTsujimoto, TatsuhiroAkahane, TakemiUemura, MasahitoFukui, Hiroshiangiogenesisinterferonhepatocellular carcinomap53vascular endothelial cell growth factorInterferon (IFN) is known as a multifunctional cytokine. The aim of this study was to examine the different effects of IFN subclass; namely, IFN-α and IFN-β, on hepatocellular carcinoma (HCC) growth especially in conjunction with angiogenesis that is known to play a pivotal role in the tumor growth. Furthermore, we also examined whether the p53 status in the tumor would alter the anti-tumoral effect of IFN against HCC growth since the p53 status reportedly affected the therapeutic effect of anti-angiogenic agents against cancer. When compared with IFN-α, IFN-β exerted a more potent inhibitory effect on HCC growth, even after the tumor was established, along with suppression of neovascularization in the tumor. A single treatment with clinically comparable low doses of IFN-β significantly inhibited HCC growth whereas the same dose of IFN-α did not. IFN-β also significantly suppressed the tumor growth both in the p53-wild and p53-mutant HCC cells. Our in vitro study revealed that IFN-β showed a more potent inhibitory effect on the endothelial cell proliferation than IFN-α as in the in vivo study. Collectively, IFN may be an alternative anti-angiogenic agent against HCC since it exerted a significant tumoricidal effect regardless of the host p53 status even at a low dose. A cautious approach may be also required in the clinical practice since even in a same IFN subclass (class-I), IFN-α and IFN-β exert tumoricidal effects of different magnitudes on HCC.Spandidos Publications2012-10-25T07:11:50Z2012-10-25T07:11:50Z2008-01Journal ArticleInternational Journal of Oncology Vol.32 No.1 pp.193-19910196439http://hdl.handle.net/10564/232110196439AA10992511International Journal of Oncology321193199enghttp://www.ncbi.nlm.nih.gov/pubmed/18097559publisher
oai:ginmu.naramed-u.ac.jp:10564/23222017-06-11T23:20:26Zhdl_10564_21Synergistic inhibitory effect of gemcitabine and angiotensin type-1 receptor blocker, losartan, on murine pancreatic tumor growth via anti-angiogenic activities.Noguchi, RyuichiYoshiji, HitoshiIkenaka, YasuhideNamisaki, TadashiKitade, MitsuteruKaji, KosukeYoshii, JunichiYanase, KojiYamazaki, MasaharuTsujimoto, TatsuhiroKawaratani, HidetoFukui, HiroshiVEGFangiogenesisgemcitabineangiotensinpancreatic tumorPancreatic cancer is one of the leading causes of cancer death, and represents a challenging chemotherapeutic problem. The crucial role of angiogenesis in tumor growth has been widely recognized, and several reports have revealed that the combination treatment of the conventional chemotherapeutic drugs and anti-angiogenic agents exerted synergistic anti-cancerous effects. It has been reported that the clinically used angiotensin type-1 receptor blocker (ARB) exerted potent anti-angiogenic activity. The aim of our current study was to examine the combination effect of gemcitabine (GEM), a widely used conventional chemotherapeutic drug against pancreas cancer, and losartan (Lo), an ARB, on murine pancreatic tumor growth, especially in conjunction with angiogenesis. When used individually, GEM and Lo at clinically comparable low doses moderately suppressed pancreatic tumor development. The combination treatment with GEM and Lo exerted a marked inhibitory effect as compared with single agent treatments even after the tumor was fully established. Neovascularization and the expression of the vascular endothelial growth factor (VEGF), a central angiogenic factor, in the tumor were both markedly suppressed in a magnitude similar to the inhibitory effects against the tumor growth. Since both agents are widely used in the clinical practice, the combination regimen of GEM and Lo may represent a potential new therapeutic strategy for pancreatic cancer in the future.Spandidos Publications2012-10-26T00:54:25Z2012-10-26T00:54:25Z2009-08ArticleJournal ArticleOncology Reports Vol.22 No.2 pp.355-3601021335Xhttp://hdl.handle.net/10564/23221021335XAA11016405Oncology Reports222355360enghttp://www.ncbi.nlm.nih.gov/pubmed/19578777http://dx.doi.org/10.3892/or_00000445publisher
oai:ginmu.naramed-u.ac.jp:10564/23232017-06-11T23:20:26Zhdl_10564_21Selective aldosterone blocker ameliorates the progression of non-alcoholic steatohepatitis in rats.Noguchi, RyuichiYoshiji, HitoshiIkenaka, YasuhideKaji, KosukeShirai, YusakuAihara, YosukeYamazaki, MasaharuNamisaki, TadashiKitade, MitsuteruYoshii, JunichiYanase, KojiKawaratani, HidetoTsujimoto, TatsuhiroFukui, Hiroshialdosteroneselective aldosterone blockerliver fibrosishepatocarcinogenesisangiogenesisAlthough non-alcoholic steatohepatitis (NASH) may progress to cirrhosis and hepatocellular carcinoma (HCC), no effective therapeutic modalities have been fully established yet. Recent studies have shown that the renin-angiotensin-aldosterone-system plays an important role in NASH. The aim of our current study was to elucidate the effects of aldosterone (Ald) inhibition on the progression of NASH. In the choline-deficient L-amino acid-defined diet-induced rat NASH model, the effects of a clinically used selective Ald blocker (SAB) were elucidated in conjunction with the activated hepatic stellate cells (HSC) and neovascularization, which are both known to play important roles in liver fibrosis development and hepatocarcinogenesis, respectively. Liver fibrosis development and the glutathione-S-transferase placental form-positive pre-neoplastic lesions were both markedly attenuated by SAB along with the suppression of the activated HSC and neovascularization. SAB inhibited the hepatic expression of transforming growth factor-β 1 and also that of the vascular endothelial growth factor. Our in vitro study showed that SAB also inhibited the Ald-induced HSC proliferation and in vitro angiogenesis in a dose-dependent manner. These results indicated that Ald plays a pivotal role in the progression of NASH. Considering that SAB is already widely used in clinical practice, this drug could represent a potential new strategy against NASH in the future.Spandidos Publications2012-10-26T01:07:59Z2012-10-26T01:07:59Z2010-09ArticleJournal ArticleInternational Journal of Molecular Medicine Vol.26 No.3 pp.407-41311073756http://hdl.handle.net/10564/232311073756AA11445762International Journal of Molecular Medicine263407413enghttp://www.ncbi.nlm.nih.gov/pubmed/20664958http://dx.doi.org/10.3892/ijmm_00000480publisher
oai:ginmu.naramed-u.ac.jp:10564/28892017-05-29T06:08:29Zhdl_10564_21Risk for lung cancer in workers exposed to benzidine and/or beta-naphthylamine: a protocol for systematic review and meta-analysis.Tomioka, KimikoSaeki, KeigoObayashi, KenjiTanaka, YuuKurumatani, NorioBenzidineBeta-naphthylamineLung cancerMortalityIncidenceOccupational exposureSystematic reviewMeta-analysisProtocolBACKGROUND:Risk for lung cancer in workers exposed to benzidine (BZ) and/or beta-naphthylamine (BNA), which are well-known bladder carcinogens, has been examined in many epidemiological studies, but individual epidemiological studies generally lack the power to examine the association between BZ/BNA exposure and lung cancer. We conduct a systematic review and meta-analysis to determine the risk for lung cancer among workers exposed to BZ/BNA occupationally.
METHODS/DESIGN:Studies will be identified by a MEDLINE, EMBASE, CDSR, and CINAHL search and by the reference lists of articles/relevant reviews. Eligible studies will be cohort and case-control studies that report occupational BZ/BNA exposure and the outcome of interest (lung cancer death/incidence). The method of meta-analysis will be used to combine standardized mortality ratios (SMRs) and/or standardized incidence ratios (SIRs) from retrospective and prospective cohort studies and odds ratios (ORs) from case-control studies. Two reviewers will independently screen articles, extract data, and assess scientific quality using standardized forms and published quality assessment tools tailored for each study design. Overall pooled risk estimates and their corresponding 95% confidence intervals (CIs) will be obtained using random effects model. This systematic review and meta-analysis will be conducted following the Meta-analysis of Observational Studies in Epidemiology (MOOSE) guidelines, and results will be reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement.DISCUSSION:
This review will identify and synthesize studies of the association between occupational BZ/BNA exposure and lung cancer. The findings will help to identify whether BZ/BNA could cause lung cancer and might indicate whether workers with exposure to BZ/BNA have a need for preventive measures against non-urological cancer besides bladder cancer.© 2014 Tomioka et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative
Commons Attribution License(http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article,unless otherwise stated.BioMed Central2015-02-09T00:49:21Z2015-02-09T00:49:21Z2014-10-03ArticleJournal ArticleSystematic reviews Vol.3 Art.No.112(3 October 2014)20464053http://hdl.handle.net/10564/288920464053Systematic reviews3112enghttp://www.ncbi.nlm.nih.gov/pubmed/25281283http://dx.doi.org/10.1186/2046-4053-3-112publisher
oai:ginmu.naramed-u.ac.jp:10564/32682017-06-11T23:20:26Zhdl_10564_21Risk of Lung Cancer in Workers Exposed to Benzidine and/or Beta-Naphthylamine: A Systematic Review and Meta-Analysis.Tomioka, KimikoSaeki, KeigoObayashi, KenjiKurumatani, Noriobenzidinebeta-naphthylaminelung canceroccupational exposuresystematic reviewBenzidine (BZ) and beta-naphthylamine (BNA) have been classified as definite human carcinogens for bladder cancer by the International Agency for Research on Cancer. However, the epidemiological evidence for an association between exposure to BZ and/or BNA and lung cancer has been inconclusive. We conducted a systematic review and meta-analysis to determine the risk for lung cancer among workers exposed to BZ/BNA. A systematic literature search was conducted to identify studies that had reported occupational BZ/BNA exposure and the outcome of interest (lung cancer death and/or incidence). Meta-analyses were performed using random effects models to combine standardized mortality ratios (SMRs) or standardized incidence ratios (SIRs). We identified 23 retrospective cohort studies including 1745 cases of lung cancer; only one study reported smoking-adjusted lung cancer risk. A significantly increased lung cancer risk (pooled SMR/SIR 1.28; 95% CI, 1.14–1.43) was observed by combining all studies, with significant heterogeneity among studies (I2 = 64.1%, P < 0.001). Effect estimates were higher for studies with direct BZ/BNA exposure (ie, dyestuff and manufacturing industries) (pooled SMR/SIR 1.58; 95% CI, 1.31–1.89), and studies that identified BZ/BNA-associated bladder cancer with SMR/SIR ≥4.7 (pooled SMR/SIR 1.68; 95% CI, 1.35–2.09). Effect estimates were similar for studies with and without concomitant occupational exposure to chromium, asbestos, arsenic, or bis(chloromethyl) ether. The cumulative meta-analysis showed that the evidence of association between occupational BZ/BNA exposure and lung cancer has been stable since 1995. Although the results of this meta-analysis have the potential for confounding by smoking and heterogeneity, our findings suggest that a finding of lung cancer following occupational BZ/BNA exposure should be considered to be a potential occupational disease.Copyright © 2016 Kimiko Tomioka et al. This is an open access article distributed under the terms of Creative Commons Attribution License,
which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Japan Epidemiological Association2016-09-21T03:53:06Z2016-09-21T03:53:06Z2016-09-05ArticleJournal ArticleJournal of epidemiology Vol.26 No.9 p.447-458 (2016 Sep)09175040http://hdl.handle.net/10564/326809175040AA10952696Journal of epidemiology269447458enghttp://www.ncbi.nlm.nih.gov/pubmed/26947956http://doi.org/10.2188/jea.JE20150233publisher
oai:ginmu.naramed-u.ac.jp:10564/38682021-04-22T16:30:09Zhdl_10564_21Analysis of Dimeric αβ Subunit Exchange between PEGylated and Native Hemoglobins (α 2 β 2 Tetramer) in an Equilibrated State by Intramolecular ββ-Cross-Linking.Matsuhira, TakashiKure, TomokoYamamoto, KeizoSakai, HiromiPeptides and proteinsOligomersMixturesChemical structureandPegylationVarious chemical modifications of hemoglobin (Hb) including PEGylation have been investigated to produce red blood cell substitutes. Some of those modifications are designed on the premise that the α2β2 tetrameric structure of Hb is fundamentally stable and that it rarely dissociates into two αβ dimers in a physiological condition. However, in the present work using the “clipping” method we detected and quantitatively analyzed the considerable degree of exchange reaction of αβ subunits between β93Cys-bis-PEGylated and native Hbs through dissociation into αβ dimers and restructuring to α2β2 tetramer in a physiological condition. The equilibrium constant (Keq) of subunit exchange reactions increased from 0.82 to 2.86 with increasing molecular weight of PEG from 2 to 40 kDa, indicating that longer PEG chains enhanced such exchange reaction. The results suggest that the exchange might occur for other modified Hbs even at a practically high concentration for use as a red blood cell substitute.This document is the Accepted Manuscript version of a Published Work that appeared in final form in Biomacromolecules, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.biomac.8b00728.American Chemical Society2021-04-22T00:26:43Z2021-04-22T00:26:43Z2018-08ArticleJournal ArticleBiomacromolecules Vol.19 No.8 p.3412-3420 (2018 Aug)15257797http://hdl.handle.net/10564/386815257797AA11435474Biomacromolecules19834123420enghttps://pubmed.ncbi.nlm.nih.gov/29952544/https://doi.org/10.1021/acs.biomac.8b00728author
oai:ginmu.naramed-u.ac.jp:10564/38692021-04-22T16:30:11Zhdl_10564_21Ring-Opening Polymerization of Hemoglobin.Matsuhira, TakashiYamamoto, KeizoSakai, HiromiRing-opening polymerizationPeptides and proteinsMonomersNucleic acid structurePolymersHemoglobin (Hb), an oxygen-carrying protein, has an α₂β₂ tetrameric structure that dissociates reversibly into two αβ dimers (α₂β₂ ⇄ 2αβ). We synthesized a cyclic Hb-ring monomer with two β subunits bound through a 10 kDa polyethylene glycol (PEG) chain. The monomer induced ring-opening polymerization to produce a supramolecular polymer via intersubunit interaction of αβ dimers of an Hb molecule at the PEG terminals. Both the ring-closed monomer and the ring-opened supramolecular polymer were then fixed covalently by intramolecular cross-linking of two β subunits. Quantification of fixed products at various monomer concentrations revealed the equilibrium constant (K), a ratio of propagation and depropagation rate constants, as 5.68 mM⁻¹. The average degree of polymerization (DP) increased proportionally, concomitantly with the initial monomer concentration. Hb polymer with DP = 13.2 (Mn = ca.1 MDa) was obtained by cross-linking at 2.33 mM. Our novel strategy of ring-opening polymerization of Hb will eventually realize a highly aligned and efficiently polymerized Hb for creating artificial oxygen carriers for a clinical use.This document is the Accepted Manuscript version of a Published Work that appeared in final form in Biomacromolecules, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.biomac.8b01789.American Chemical Society2021-04-22T00:57:05Z2021-04-22T00:57:05Z2019-04ArticleJournal ArticleBiomacromolecules Vol.20 No.4 p.1592-1602 (2019 Apr)15257797http://hdl.handle.net/10564/386915257797AA11435474Biomacromolecules20415921602enghttps://pubmed.ncbi.nlm.nih.gov/29039992/https://doi.org/10.1021/acs.biomac.8b01789author
oai:ginmu.naramed-u.ac.jp:10564/38702022-06-30T16:30:08Zhdl_10564_21Entropy-Driven Supramolecular Ring-Opening Polymerization of a Cyclic Hemoglobin Monomer for Constructing a Hemoglobin-PEG Alternating Polymer with Structural Regularity.Matsuhira, TakashiSakai, HiromiRing-opening polymerizationPeptides and proteinsEquilibriumMonomersPolymersOur earlier report described that a cyclic hemoglobin (Hb) monomer with two β subunits of a Hb molecule (α₂β₂) bound through a flexible polyethylene glycol (PEG) chain undergoes reversible supramolecular ring-opening polymerization (S-ROP) to produce a supramolecular Hb polymer with a Hb–PEG alternating structure. In this work, we polymerized cyclic Hb monomers with different ring sizes (2, 5, 10, or 20 kDa PEG) to evaluate the thermodynamics of S-ROP equilibrium. Quantification of the produced supramolecular Hb polymers and the remaining cyclic Hb monomers in the equilibrium state revealed a negligibly small enthalpy change in S-ROP (ΔHp ≤ 1 kJ·mol⁻¹) and a markedly positive entropy change increasing with the ring size (ΔSp = 26.8–33.2 J·mol⁻¹·K⁻¹). The results suggest an entropy-driven mechanism in S-ROP: a cyclic Hb monomer with the larger ring size prefers to form a supramolecular Hb polymer. The S-ROP used for this study has the potential to construct submicrometer-sized Hb–PEG alternating polymers having structural regularity.This document is the Accepted Manuscript version of a Published Work that appeared in final form in Biomacromolecules, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.biomac.1c00061.American Chemical Society2021-04-22T01:08:41Z2021-04-22T01:08:41Z2021-05-10ArticleJournal ArticleBiomacromolecules Vol.22 No.5 p.1944-1954 (2021 May)15257797http://hdl.handle.net/10564/387015257797AA11435474Biomacromolecules22519441954enghttps://pubmed.ncbi.nlm.nih.gov/33856766/https://doi.org/10.1021/acs.biomac.1c00061author