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oai:ginmu.naramed-u.ac.jp:10564/20582017-06-11T23:20:26Zhdl_10564_2056表紙、目次、投稿規定、奥付(Vol.41 No.3)表紙目次投稿規定奥付奈良医学会2012-03-14T04:56:16Z2012-03-14T04:56:16Z1990-06-30OtherOthers1783711 bytesapplication/pdf奈良医学雑誌 Vol.41 No.30469555013450069http://hdl.handle.net/10564/205804695550AN00180974奈良医学雑誌413jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/20592017-06-11T23:20:26Zhdl_10564_2056Campylobacter jejuniの肝障害性に関する研究STUDIES OF THE HEPATOPATHOGENESIS OF CAMPYLOBACTER JEJUNI安井, 浩一Campylobacter jejunihepatitishepatotoxic factor(s)mouse hepatocytesMice orally infected Campylobacter jejuni developed focal infiltrative necrotic lesions in the liver, as determined by both histology and liver function tests. Histopathological feature of the liver, a focal infiltrative necrosis, was seen between days 30 and 60 postinoculation, and it became gradually more profound with time, despite the fact that liver functions of infected mice were most affected at 2 months postinoculation. The capacity of C. jejuni to induce hepatic lesions seemed to be related to that of organisms to persist in the gall bladdar. Hepatic lesions following C. jejuni infection was attributable to the hepatotoxic factor which was isolated from the subcellular components of bacteria by two series of chromatographic separations. This factor was able to induce hepatitis after it was injected intravenously into mice at a dose of 10 μg. Hepatotoxic activity of this factor was confirmed by incubating several doses of this factor with mouse hepatocytes : at low concentrations (<5 μg/ml) hepatocytes became rounding-up, while at high concentrations (>20 μg/ml) they exhibited cytolytic changes. Among 20 clinical isolates of C. jejuni, only four strains evoked hepatitis in mice and produced the hepatotoxic factor.奈良医学会2012-03-14T05:08:42Z2012-03-14T05:08:42Z1990-06-30ArticleDepartmental Bulletin Paper2609948 bytesapplication/pdf奈良医学雑誌 Vol.41 No.3 p.217-2300469555013450069http://hdl.handle.net/10564/205904695550AN00180974奈良医学雑誌413217230jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/20602017-05-29T06:08:12Zhdl_10564_2056橋本病とシェーグレン症候群を合併した多発性筋炎の1症例A CASE OF POLYMYOSITIS ASSOCIATED WITH CHRONIC THYROIDITIS AND SJÖGREN'S SYNDROME山口, 充子土肥, 和紘椎木, 英夫藤井, 謙裕石川, 兵衞chronic thyroiditispolymyositisSjögren's syndromeA 57-year-old man with polymyositis complicated by chronic thyroiditis and Sjögren's syndrome is repoted. The patient developed muscle weakness and myalgia of the extremities, joint pain in the elbow and hip, and dry mouth around February 1982. The laboratory data on admission revealed serum CPK, LDH, and creatine, and urinary creatine coefficient. Thyroid function test showed lowered T₃, T₄, free T₃ and free T₄ with elevation of TSH. In EMG, typical myogenic changes were observed. The histological features of biopsy specimens obtained from the submandibular gland and thyroid corresponded to those of Sjögren's syndrome and chronic thyroiditis, respectively. Prednisolone therapy was followed by improvement of the clinical symptoms as well as thyroid function.奈良医学会2012-03-14T05:28:39Z2012-03-14T05:28:39Z1990-06-30ArticleDepartmental Bulletin Paper1022085 bytesapplication/pdf奈良医学雑誌 Vol.41 No.3 p.231-2360469555013450069http://hdl.handle.net/10564/206004695550AN00180974奈良医学雑誌413231236jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/20612017-05-29T06:08:06Zhdl_10564_2056半月体形成をともなう膜性腎症を合併した慢性関節リウマチの1例A CASE OF MEMBRANOUS NEPHROPATHY WITH CRESCENTS IN RHEUMATOID ARTHRITIS川野, 貴弘神元, 章雄吉村, 克敏山中, 富美男土肥, 和紘椎木, 英夫金内, 雅夫石川, 兵衞crescentic glomerulonephritismembranous nephropathyrheumatoid arthritisrheumatoid vasuculitisA case of membranous nephropathy with crescents in rheumatoid arthritis is reported. This patient was a 59-year-old male with longstanding rheumatoid arthritis. He developed renal dysfunction, proteinuria and hematuria. Neither gold nor pencillamine
was given. Real biopsy revealed membranous nephropathy with various stages of crescents.
This case showed improvement in renal function with predonisolone treatment. Although the actual mechanism remains unclear, it seems likely that a mechanism similar to rheumatoid vasculitis or necrotizing glomerulonephritis may superimpose on pre-existing membranous nephropathy.奈良医学会2012-03-14T06:41:20Z2012-03-14T06:41:20Z1990-06-30ArticleDepartmental Bulletin Paper1078813 bytesapplication/pdf奈良医学雑誌 Vol.41 No.3 p.237-2420469555013450069http://hdl.handle.net/10564/206104695550AN00180974奈良医学雑誌413237242jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/20622017-05-29T06:08:12Zhdl_10564_2056肺癌組織におけるレクチン結合性LECTIN BINDINGS REVEALED BY SEMI-QUANTITATIVE IMMUNOHISTOCHEMISTRY IN HUMAN LUNG CANCER福岡, 和也lectin immunohistochemistrylung cancersialic acidIn order to find a cancer specific pattern of lectin bindings, semiquantitative immunohistochemical analysis using a panel of lectins (DBA, UEA-Ⅰ, RCA-Ⅰ, WGA, ConA, PNA) was conducted on fresh-frozen tissue sections of non-cancerous bronchus, metaplastic bronchus and lung cancer. The following results were obtained : 1) In non-cancerous bronchus, the binding distributions of RCA-Ⅰ, WGA, ConA, and PNA with neuraminidase (PNA•N(+)) were observed in almost all tissue components ; in contrast, those of DBA, DBA•N(+), UEA-Ⅰ, and PNA were localized in bronchial epithelial cells, bronchial glands, and endothelial cells. 2) All the lectins except for PNA bound to the metaplastic bronchial epithelial cells. 3) Almost all the cancerous tissues were positively stained with UEA-Ⅰ, RCA-Ⅰ, WGA, ConA, and PNA•N(+). DBA was found to bind adenocarcinomas preferentially to squamous cell carcinomas and small cell carcinomas. 4) Bindings of DBA and UEA-Ⅰ in lung cancer tended to be correlated with cancer cell differentiation.
5) There were relationships between DBA, UEA-Ⅰ, RCA-Ⅰ, and PNA bindings and clinical staging in lung cancer. 6) DBA and UEA-Ⅰ bindings showed no relationship with ABO blood group status of lung cancer patients. 7) The incidence of the phenotype, PNA, PNA•NC(+)⁺ representing the cryptic PNA binding sites were masked by sialic acids might be correlated with the serum CEA values in squamous cell carcinoma and lymphnodes metastasis. In conclusion, semi-quantitative lectin immunohistochemistry using DBA, UEA-Ⅰ, and PNA contributes to the assessment of various abnormalites of glycoconjugates associated with lung cancer.奈良医学会2012-03-14T07:38:22Z2012-03-14T07:38:22Z1990-06-30ArticleDepartmental Bulletin Paper3130534 bytesapplication/pdf奈良医学雑誌 Vol.41 No.3 p.243-2600469555013450069http://hdl.handle.net/10564/206204695550AN00180974奈良医学雑誌413243260jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/20632012-03-15T04:24:02Zhdl_10564_2056先天性骨形成不全症(Osteogenesis imperfecta congenita)の2例TWO CASES OF OSTEOGENESIS IMPERFECTA CONGENITA久世, 晋徳今中, 康文高橋, 綾子武田, 以知郎上辻, 秀和根津, 智子高瀬, 俊夫西久保, 敏也南淵, 芳瓜生, マキ一条, 元彦osteogenesis imperfecta congenitaskeletal dysplasiaSillence classificationWe observed 2 cases of osteogensis imperfecta congenita. They were born after 38 weeks gestation, weighed less than 2,500g, and had blue sclera or short limbs. Their roentgenograms showed multiple fracture of the ribs and ostopenia in the skull. They died in a few months after birth, of respiratory insufficiency due to a defective thoracic cage. These findings suggest that the 2 cases were osteogenesis imperfecta congenita Type ⅡA.個人の特定が出来ると思われる写真が掲載されているため本文PDFの登録はなし奈良医学会2012-03-15T04:23:11Z2012-03-15T04:23:11Z1990-06-30ArticleDepartmental Bulletin Paper745806 bytesapplication/pdf奈良医学雑誌 Vol.41 No.3 p.261-2640469555013450069http://hdl.handle.net/10564/206304695550AN00180974奈良医学雑誌413261264jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/20642017-05-29T06:08:13Zhdl_10564_2056重症クモ膜下出血の経過中に発症した中枢性肺水腫の検討 : 急性期手術の適否に関してCLINICAL ANALYSIS OF NEUROGENIC PULMONARY EDEMA FOLLOWING SEVERE SUBARACHNOID HEMORRHAGE : DIRECT SURGERY IN THE ACUTE STAGE中村, 光利榊, 寿右京井, 喜久男内海, 庄三郎宮本, 誠司鎌田, 喜太郎青山, 信房neurogenic pulmonary edemasubarachnoid hemorrhagepositive end-expiratory pressureNeurogenic pulmonary edema (NPE) following severe subarachnoid hemorrhage (SAH) have been reported recently. The incidence, the treatment and the prognosis of NPE are discussed among authors. In this study, 11 cases of SAH complicated with NPE are reported, and clinical features, especially the best timing for surgery, are discussed. Among 460 patients admitted for SAH during a recent three-year period, 11 cases (2.3%) were complicated with NPE. According to Hunt & Kosnik grading on admission, one patient was in Grade Ⅱ, two were in Grade Ⅲ, three were in Grade Ⅳ and five were in Grade Ⅴ. Chest X-ray films demonstrated a typical pattern such as snowstorm-like shadowing in each case. CT revealed a diffuse subarachnoid hemorrhage or intraventricular homorrhage (Fisher type Ⅲ or Ⅳ) in each case. In 8 cases, artificial respiratory control with positive end-expiratory pressure (PEEP) following intratracheal intubation were successful, and NPE was improved within one to 8 days. Four patients
underwent an aneurysm surgery combined with the management of NPE in the acute stage. These outcomes were very good and they were discharged without major neurological deficit. The acquired results showed that NPE associated with severe SAH can be successfully treated and promptly improved the distinct management. Therefore direct surgery in the acute stage is not necessarily taboo if the appropriate respiratory and cardiovascular management can be given. The prognosis of patients with severe SAH complicated with NPE depends not the severities of NPE but on those of SAH. In conclusion, we recommend early direct surgery combined with distinct management of NPE in poor grade patients because it encabled us to control increased ICP and apply artificial ventilation with PEEP.奈良医学会2012-03-15T05:08:39Z2012-03-15T05:08:39Z1990-06-30ArticleDepartmental Bulletin Paper1638476 bytesapplication/pdf奈良医学雑誌 Vol.41 No.3 p.265-2720469555013450069http://hdl.handle.net/10564/206404695550AN00180974奈良医学雑誌413265272jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/20652012-03-15T07:42:59Zhdl_10564_2056重症型および軽症型Hunter症候群の各一例HUNTER SYNDROME : REPORT OF A SEVERE AND A MILD CASE吉田, 裕慈大久保, 芳明吉岡, 章平, 康二寺田, 茂紀碇, 久雄Hunter syndromemucopolysaccharidosisiduronate sulfatasecarrier detectionhair rootHunter syndrome is one of several types of mucopolysaccharidosis and is inherited in an X-linked recessive manner. Severity of Hunter syndrome is distinguished by the degree of intellectual impairment and prognosis. We report here two cases, one of the clinically severe and the other of mild form of Hunter syndrome. Activity of iduronate sulfatase was extremely reduced in both patients' cultured lymphocytes. We also performed carrier detection of each patient's mother by the determination of α-L-iduronate sulfatase and β-hexosaminidase activities using the hair root.個人の特定が出来ると思われる写真が掲載されているため本文PDFの登録はなし奈良医学会2012-03-15T07:10:41Z2012-03-15T07:10:41Z1990-06-30ArticleDepartmental Bulletin Paper1301565 bytesapplication/pdf奈良医学雑誌 Vol.41 No.3 p.273-2790469555013450069http://hdl.handle.net/10564/206504695550AN00180974奈良医学雑誌413273279jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/20662017-05-29T06:08:16Zhdl_10564_2056奈良県立医科大学附属病院輸血部における過去10年間の赤血球不規則性抗体の検出統計CUMULATIVE STATISTICS OF ANTI-RED BLOOD CELL IRREGULAR ANTIBODIES DETECTED AT NARA MEDICAL UNIVERSITY HOSPITAL DURING THE PAST 10 YEARS西田, 幸世辻, 令子秀能井, 正隆内田, 麻里前田, 美和石本, 盛治藤村, 吉博福井, 弘内田, 和人山根, 敏子嶋, 裕子中島, 克子市場, 邦通red blood cellirregular antibodyanti-Diªanti-JrªAnti-red blood cell (RBC) irregular antibody is a “hallmark" of antibodies which are produced by stimulating antigens "out-of-the-law" of Landsteiner. Experience has indicated that antibodies that are reactive only at temperatures below 37℃ are clinically benign except for certain clinical conditions such as hypothermic cardiac surgery. During the past 10 years, we have screened a total of 29,408 blood samples and found that 557 cases (1.9%) have irregular antibodies to specific antigen on RBC that are reactive at either 37℃ or below 37℃, or at both. Both the screening and identification tests for antibody detection were performed using a commercial kit (Ortho Co.) and by the methods of saline, bromelin, albumin, and Coombs. Prevalence of irregular antibody was in the following order ; anti-Lewis 39.3%, anti-P₁ 31.8%, anti-E (with complex form) 12.8%, anti-D 2.5%, and others 13.6%. Clinical course and laboratory findings of two rare cases having anti-Diª or anti-Jrª are also described on this specific occasion.奈良医学会2012-03-15T07:40:15Z2012-03-15T07:40:15Z1990-06-30ArticleDepartmental Bulletin Paper550242 bytesapplication/pdf奈良医学雑誌 Vol.41 No.3 p.280-2850469555013450069http://hdl.handle.net/10564/206604695550AN00180974奈良医学雑誌413280285jpnpublisher