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oai:ginmu.naramed-u.ac.jp:10564/20482017-06-11T23:20:26Zhdl_10564_2047表紙、目次、投稿規定、奥付(Vol.41 No.4)表紙目次投稿規定奥付奈良医学会2012-03-12T06:40:55Z2012-03-12T06:40:55Z1990-08-31OtherOthers1874874 bytesapplication/pdf奈良医学雑誌 Vol.41 No.40469555013450069http://hdl.handle.net/10564/204804695550AN00180974奈良医学雑誌414jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/20492017-05-29T06:08:12Zhdl_10564_2047Korsakoff症候群を合併した後頭葉梗塞の神経放射線学的検討NEURORADIOLOGICAL STUDY ON OCCIPITAL INFARCTION WITH KORSAKOFF'S SYNDROME合田, 和生角田, 茂榊, 寿右森本, 哲也藤田, 豊久川田, 和弘柿崎, 俊雄岩崎, 聖Korsakoff's syndromecerebral infarctioncortical blindnessPapez circuitAnton's syndromeKorsakoff's syndrome is characterized by impairment of recent memory, disorientation and confabulation, and is now thought to be caused by bilateral damage of the Papez circuit. We conducted neuroradiological study of occipital infarction with Korsakoff's syndrome. CT findings allowed us to divide the cases into two groups. Group 1 (bilateral type) showed bilateral occipital infarction on CT, severe stenosis of the basilar bifurcation on angiography, and is clinically associated with Korsakoff's syndrome and cortical blindness. Differential diagnosis of this condition from Anton's syndrome should be made by confirming whether there is dementia or not. Group 2 (unilateral type) showed left occipitotemporal infarction on CT, obstruction of the left P₁ portion on angiography, and in clinically associated with Korsakoff's syndrome, right homonymous hemianopsia, right hemiplegia and right hemisensory disturbance. From the point of pathogenesis, Korsakoff's syndrome is caused by infarction of the bilateral mamillary body in Group 1, and the left mamillary body and hippocampus in Group 2. We point out that Korsakoff's syndrome will occur by unilateral damage of the Papez circuit on the dominant side.奈良医学会2012-03-12T07:19:45Z2012-03-12T07:19:45Z1990-08-31ArticleDepartmental Bulletin Paper768043 bytesapplication/pdf奈良医学雑誌 Vol.41 No.4 p.287-2910469555013450069http://hdl.handle.net/10564/204904695550AN00180974奈良医学雑誌414287291jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/20502017-05-29T06:08:09Zhdl_10564_2047胃癌と十二指腸癌が重複した1症例A CASE OF DOUBLE CANCER IN THE STOMACH AND THE DUODENUM森田, 博北神, 敬司七川, 歓次富土, 正夫辻, 求山尾, 純一福井, 博森田, 倫史辻井, 正gastric cancerduodenal cancerdouble cancerno metastasisautopsy caseA case of double cancer of the stomach and the duodenum is reported. A 72-year-old man developed vomiting in August 1986 and epigastralgia in October, and he was referred to our hospital for further examination and treatment. An upper gastrointestinal X-ray series revealed ulcerative tumor in the anterior wall of the gastric antrum and in the infra-ampullary portion of the duodenum. The pathological diagnosis of the biopsy specimen was adenocarcinoma of the stomach and benign duodenal tumor. However, the possibility of duodenal cancer had been suspected from the macroscopic findings. He died of pneumonia and renal failure in December 1986. The macrospecimen at autopsy showed 4.7×4.4 cm Borrmann 2 cancer in the stomach and 2.0×2.3 cm Borrmann 2 cancer in the duodenum. Histologically they were well differentiated tubular adenocarcinoma and moderately differentiated tubular adenocarcinoma respectively. But there were no invasions to the pancreas and common bile duct or metastasis to the lymph nodes, liver and so on. This type of double cancer is very rare, and to our knowledge, only nine cases including our case have been reported in Japan.奈良医学会2012-03-12T08:17:48Z2012-03-12T08:17:48Z1990-08-31ArticleDepartmental Bulletin Paper1476844 bytesapplication/pdf奈良医学雑誌 Vol.41 No.4 p.292-2980469555013450069http://hdl.handle.net/10564/205004695550AN00180974奈良医学雑誌414292298jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/20512017-05-29T06:08:14Zhdl_10564_2047脳内出血における大脳・脳幹誘発電位の臨床的研究CLINICAL STUDY OF CORTICAL AND BRAINSTEM EVOKED POTENTIALS IN PATIENTS WITH INTRACEREBRAL HEMORRHAGE平林, 秀裕hypertensive intracerebral hemorrhageshort-latency somatosensory evoked potentialbrainstem auditory evoked potentialCTprognosisBrainstem auditory evoked potentials (BAEP) and shortlatency somatosensory evoked potentials (SSEP) were examined in a total of 148 patients with hypertensive intracranial hemorrhage (brainstem in 31, cerebellum in 13, thalamus in 42 and putamen in 62). BAEPs were divided into 5 grades : Grade Ⅰ for normal Ⅰ-Ⅴ IPL (4.1±0.2 msec) ; Grade Ⅱ for the presence of waves Ⅰ-Ⅴ on both sides with prolongation of Ⅰ-Ⅴ IPL (>4.5 msec) ; Grade Ⅲ for the disappearance of wave Ⅴ at least on one side and the pressence of waves Ⅰ-Ⅲ on both sides ; Grade Ⅳ for the presence of only wave Ⅲ on one side ; and Grade Ⅴ for the absence of response on both sides. SSEPs were also divided into 5 grades : Grade Ⅰ for normal CCT (5.8±0.4 msec) ; Grade Ⅱ for prolongation of CCT (>6.6 msec) ; Grade Ⅲ for nonresponse on the affected side and normal CCT on the other ; Grade Ⅳ for nonresponse on the affected side and prolongation of CCT on the other ; and Grade Ⅴ for nonresponse on both sides. The neurological findings, CT findings and prognosis were comparatively studied in relation to these BAEP and SSEP grades. The BAEP grading reflected the severity of consciousness disturbance and was useful for prediction of prognosis in posterior fossa hemorrhage. It was useful as a guide to indication of surgical intervention in cerebellar hemorrhage. For supratentorial lesions, however, it was not helpful in pathological assessment. The SSEP grading proved to be useful for prediction of prognosis in intcranial hemorrhage occurring in any region of the brain structure. It reflected the degree of consciousness disturbance in brainstem hemorrhage. It was effective as a guide to the choice of surgical treatment methods in cerebeller or putaminal hemorrhage.奈良医学会2012-03-13T05:45:52Z2012-03-13T05:45:52Z1990-08-31ArticleDepartmental Bulletin Paper2077216 bytesapplication/pdf奈良医学雑誌 Vol.41 No.4 p.299-3180469555013450069http://hdl.handle.net/10564/205104695550AN00180974奈良医学雑誌414299318jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/20522017-05-29T06:08:14Zhdl_10564_2047肝硬変と膜性増殖性糸球体腎炎様病変を合併した日本住血吸虫症の1剖検例A RARE AUTOPSY CASE OF SCHISTOSOMA JAPONICA COMPLICATED WITH LIVER CIRRHOSIS AND SECONDARY MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS藤本, 順一郎土肥, 和紘椎木, 英夫中堀, 克巳林, 需石川, 兵衞Schistosoma japonicasecondary membranoproliferative glomerulonephritisliver cirrhosisAn 80-year-old female was hospitalized because of abdominal bulging. She was diagnosed as having discomensatory liver cirrhosis, judging from her physical findings
and laboratory data. Her ascites immidiately disappeared after duretics were administered.
However, eight weeks after admission, her ascites developed and were reflectory to diuretics. Her consciousness was confused, and 12 weeks later, she died of aspiration
pneumonia. The autopsy findings were as follows. The liver was cirrhotic and Schistosoma japonica (Sj) eggs were scatteredly present in the Glisson's capsule. The kidneys contained lesions
which resembled membranoproliferative glomerulonephritis (MPGN). She was finally
diagnosed as having Sj complicated with liver cirrhosis and secondary MPGN. It seemed
that the occurrence of MPGN was related with immunological reactions of Sj. We here report a rare autopsy case of Sj complicated liver cirrhosis and secondary MPGN.奈良医学会2012-03-13T06:00:10Z2012-03-13T06:00:10Z1990-08-31ArticleDepartmental Bulletin Paper1013686 bytesapplication/pdf奈良医学雑誌 Vol.41 No.4 p.319-3240469555013450069http://hdl.handle.net/10564/205204695550AN00180974奈良医学雑誌414319324jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/20532017-05-29T06:08:16Zhdl_10564_2047ニバレノール(マイコトキシン)の代謝と毒性機構に関する研究 : 第一報.ニバレノールの単離精製と新代謝物 ; 脱エポキシニバレノールの同定STUDIES ON METABOLISM AND TOXICITIES OF NIVALENOL (MYCOTOXIN) : Ⅰ. PURIFICATION OF NIVALENOL AND IDENTIFICATION OF NEW METABOLITE OF NIVALENOL, DEEPOXYNIVALENOL陰地, 義樹trichothecene mycotoxinnivalenoldeepoxynivalenolLarge amounts of two mycotoxins, nivalenol and fusarenon-X were produced from Fusarium graminearum F-1465 cultured on pressed barley. The centrifugal partition chromatography (CPC) using two-phase solvent systems n-butanol-water and chloroform-methanol-water could be applied to a preparative purification of nivalenol and fusarenon-X. Starting from the Fusarium grown on 1 kg of pressed barley substrate, 0.34 g of nivalenol and 0.78 g of fusarenon-X were obtained by recrystallization of CPC fraction from hot methanol. Fusarenon-X was converted to nivalenol by alkaline hydrolysis giving to 0.55 g of crystalline nivalenol. A new metabolite of nivalenol was detected in the feces of rats when nivalenol was administered orally. The new metaboite was identified as 3, 4, 7, 15-tetrahydroxytrichothec-9, 12-dien-8-one, or deepoxynivalenol, on the basis of mass spectrometry and ¹H and ¹³C nuclear magnetic resonance spectroscopy. In repeated oral administration, the deepoxy metabolite was detected in feces at 80% and in urine at 1% of total dose, and the parent compound was detected in feces at 7% and in urine at 1%, respectively.奈良医学会2012-03-13T06:33:13Z2012-03-13T06:33:13Z1990-08-31ArticleDepartmental Bulletin Paper869563 bytesapplication/pdf奈良医学雑誌 Vol.41 No.4 p.325-3340469555013450069http://hdl.handle.net/10564/205304695550AN00180974奈良医学雑誌414325334jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/20542017-05-29T06:08:14Zhdl_10564_2047ニバレノール(マイコトキシン)の代謝と毒性機構に関する研究 : 第二報.ラットにおけるニバレノールの吸収,代謝,排泄および毒性についてSTUDIES ON METABOLISM AND TOXICITIES OF NIVALENOL (MYCOTOXIN) : Ⅱ. ABSORPTION, METABOLISM, EXCRETION, AND TOXICITIES OF NIVALENOL IN RATS陰地, 義樹trichothecene mycotoxinnivalenolabsorptionmetabolismexcretiontoxicityAbsorption, distribution, and excretion of nivalenol and its major metabolite, deepoxynivalenol, were invesitigated in male rats after a single intraperitoneal (1 mg/Kg) or oral (5 mg/Kg) administration. After intraperitoneal administration, nivalenol and deepoxynivalenol excreted by the rats in urine were 48.3% and 3.8% of the
total dose given respectively, and those excreted in feces were 10.0% and 25.5% of the dose, respectivly, within 72 hr. On the contrary, in oral administration, nivalenol and deepoxynivalenol excreted in urine were 9.9% and 5.6% of the dose, respectively, and those excreted in feces were 5.4% and 18.7% of the dose, respectively, in 72 hr. Deepoxynivalenol was excreted in feces to a higher extent than in urine and later than nivalenol. The levels of nivalenol detected in serum, liver and kidney were much lower than in urine or feces even 1 hr after oral dosing and were rapidly lowered. Deepoxynivalenol was not detected in serum, liver, or kidney at any time within 24 hr. The major metabolic pathways of nivalenol in rats are considered to be the deepoxidation at 12, 13-epoxide ring in the gastrointestine. The effect of feeding diets containing 0, 10, and 50 μg/g of nivalenol for 8 weeks on the growth rate, hematology, and histopathology were also examined. In 50 μg/g nivalenol dosing group, body-weight gain was significantly reduced and weak erythrocytopenia was observed. Histopathologically, mucosal necrosis and the disruption of gut epithelium, and an increase of erythroid series in bone marrow was observed. However, in 10 μg/g nivalenol dosing group, no significant change was observed in comparison with the control group.奈良医学会2012-03-13T07:55:02Z2012-03-13T07:55:02Z1990-08-31ArticleDepartmental Bulletin Paper1229559 bytesapplication/pdf奈良医学雑誌 Vol.41 No.4 p.335-3430469555013450069http://hdl.handle.net/10564/205404695550AN00180974奈良医学雑誌414335343jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/20552017-05-29T06:08:14Zhdl_10564_2047奈良医大精神科外来における児童および思春期の患者の現況THE CONDITION OF CHILD AND ADOLESCENT PSYCHIATRIC PRACTICE AT THE PSYCHIATRIC DEPARTMENT IN NARA MEDICAL UNIVERSITY岩坂, 英巳飯田, 順三平尾, 文雄松村, 一矢井川, 玄朗child and adolescent psychiatrystatistical dataschool refusalDSM-Ⅲ-R diagnostic criteriaStatistical research was conducted on the out-patients who were under 18 years of age at their first visit to the psychiatric clinic at Nara Medical University Hospital from April 1982 to March 1983 and from April 1987 to March 1988. We adapted DSM-Ⅲ-R criteria to all patients and compared with classical diagnosis. The results are as follows. 1. 104 out-patients (55 male, 49 female) were seen from April 1982 to March 1983, and 121 out-patients (59 male, 62 female) were seen from April 1987 to March 1988. 2. About 20% of the patients visited the Departement of Psychiatry through the
referral from the Departments of Pediatics and Internal Medicine in Nara Medical University. But there were few refferals from schools or children's consulting centers
3. The number of cases of Neurosis occupied about 50% of total cases. This is common to any other hospitals. 4. There is no category of School Refusal and Neurosis in DSM-Ⅲ-R, and so we tentatively categorized the patients with school refusal and neurosis accoding to DSM-Ⅲ-R. 5. School Refusal has incresed, especially among pupils in the higher grades of elementary schools and female junior high school students.奈良医学会2012-03-13T08:23:16Z2012-03-13T08:23:16Z1990-08-31ArticleDepartmental Bulletin Paper980907 bytesapplication/pdf奈良医学雑誌 Vol.41 No.4 p.344-3530469555013450069http://hdl.handle.net/10564/205504695550AN00180974奈良医学雑誌414344353jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/20572017-05-29T06:07:10Zhdl_10564_2047奈良県立医科大学附属病院口腔外科開設後5年間における外来患者の臨床統計的観察CLINICO-STATISTICAL OBSERVATION ON THE OUT-PATIENTS AT DEPARTMENT OF ORAL AND MAXILLOFACIAL SURGERY, NARA MEDICAL UNIVERSITY HOSPITAL DURING THE FIRST FIVE YEARS堀内, 克啓服部, 明伸吉川, 智也中橋, 一裕土田, 雅久西岡, 博人露木, 基勝浅香, 信竹内, 尚則望月, 光治吉田, 育弘権, 利文桐田, 忠昭植村, 和嘉匠原, 悦雄河野, 孝行杉村, 正仁clinico-statistical observationoral and maxillofacial surgeryThe authors performed clinico-statistical observation on 10,013 out-patients who presented during the five years following the inception of Department of Oral and Maxillofacial Surgery, Nara Medical University Hospital, on 19th October 1976. The results are as follows : 1. The yearly average number of out-patients was 2,003, which was the largest of any Departmant of Dentistry and/or Oral and Maxillofacial Surgery Medical University Hospital. 2. 7,448 patients (74.4%) had diseases associated with oral and maxillofacial surgery, who were divided into the following 14 groups : inflammations (21.8%), traumas (19.4%), diseases of temporomandibular joint (12.1%), diseases of oral mucosa (8.7%), impacted teeth (7.1%), cysts (6.9%), tumors and tumor-like diseases (5.6%), anomalies (3.7%), diseases of salivary gland (2.3%), iatrogenic diseases (1.9%), diseases of nervous system (1.3%), blood diseases (0.5%), jaw deformities (0.2%), and others (7.8%). 3. 7,273 patients (72.6%) were referred by dentists (30.7%), medical doctors (35.9%) and others (6.0%). Patients with diseases of TMJ were referred by orthopedists (25.1%) more than dentists (22.1%), which suggests that this disease has not been generally recognized yet. 4. In 1,812 patients with general dental diseases, 832 patients (45.9%) had systemic diseases.奈良医学会2012-03-14T04:49:04Z2012-03-14T04:49:04Z1990-08-31ArticleDepartmental Bulletin Paper997630 bytesapplication/pdf奈良医学雑誌 Vol.41 No.4 p.354-3630469555013450069http://hdl.handle.net/10564/205704695550AN00180974奈良医学雑誌414354363jpnpublisher