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oai:ginmu.naramed-u.ac.jp:10564/19882017-06-11T23:20:26Zhdl_10564_1987表紙、目次、投稿規定、奥付(Vol.42 No.2)表紙目次投稿規定奥付奈良医学会OtherOthersapplication/pdf奈良医学雑誌 Vol.42 No.20469555013450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/1988奈良医学雑誌, 42(2)http://hdl.handle.net/10564/1988http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/1988/1/%e8%a1%a8%e7%b4%99%e3%80%81%e7%9b%ae%e6%ac%a1%e3%80%81%e6%8a%95%e7%a8%bf%e8%a6%8f%e5%ae%9a%e3%80%81%e5%a5%a5%e4%bb%98%28Vol.42_No.2%29.pdf04695550AN00180974奈良医学雑誌4221991-04-30jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/19892017-05-29T06:07:52Zhdl_10564_1987大腸癌の臨床・病理学的動向 : 当教室における過去18年間の大腸癌症例の検討A STUDY FOR CLINICO-PATHOLOGICAL TRENDS OF PRIMARY COLORECTAL CANCER CASES仲川, 昌之藤井, 久男山本, 克彦佐道, 三郎山本, 雅敏渡邊, 巌安田, 慎治吉川, 周作中野, 博重colorectal cancertrend of clinico-pathological factorStatistical examinations were performed on clinico-pathological factors of 505 primary colorectal cancer cases treated at the First Department of Surgery of Nara Medical University during 18 years (from April, 1972 to March, 1990). They were divided in two groups : one is the first term group which consists of cases between April, 1972 and
March, 1982. and the other is the latter term group between April, 1982 and March, 1990. Clinico-pathological trends were studied by comparing the two groups. The results were as follows. 1. The average number of annual cases in the latter term increased 1.6 times compared with that in the first term. 2. The sexual difference of colorectal cancers decreased from 1.6 (male/female) to 1.3. 3. The ratio of the rectum/colon also decreased from 1.6 to 0.93. This change was more significant in females (from 1.96 to 1.05). This result suggests the relative increase of colonic cancer in females. 4. Regarding the distribution of the location, sigmoid colon increased and middle and lower rectum decreased (from 15.8% to 25.9%, 27% to 15.1%, 28.6% to 22.4%, respectively). But in the other portions there was no significant change. So the ratios of sigmoid colon and rectum/whole large intestine were even in both periods. 5. The ratio of curative operation was about 75% at the latter term. There were many reasons for non-curative operations including liver metastasis, peritoneal disseminations and metastasis to other organs except liver (colon cases 22%, rectal cases 8.5%). Especially the liver metastasis occurred in 54% of non-curatively operated colon cancers and 61% of rectal cancers.奈良医学会ArticleDepartmental Bulletin Paperapplication/pdf奈良医学雑誌 Vol.42 No.2 p.111-1180469555013450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/1989奈良医学雑誌, 42(2): 111-118http://hdl.handle.net/10564/1989http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/1989/1/111-118p%ef%bc%9a%e5%a4%a7%e8%85%b8%e7%99%8c%e3%81%ae%e8%87%a8%e5%ba%8a%e3%83%bb%e7%97%85%e7%90%86%e5%ad%a6%e7%9a%84%e5%8b%95%e5%90%91.pdf04695550AN00180974奈良医学雑誌4221111181991-04-30jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/19902017-05-29T06:07:52Zhdl_10564_1987身体診療科共観目的で精神科病棟に入院した精神障害患者についてPSYCHIATRIC PATIENTS WHO WERE ADMITTED TO THE PSYCHIATRIC WARD FOR THE PURPOSE OF TREATING SOMATIC ILLNESS鶴薗, 琢也広瀬, 高志松山, 光晴松村, 一矢橋野, 健一田原, 宏一青山, 富貴子平井, 基陽井川, 玄朗somatic complicationgeneral hospital psychiatrypsychiatric wardSome psychiatric cases are complicated by somatic illnesses during the treatment of mental disorder. This can become a troubling question for psychiatrists. For example, it may become a subject of discussion whether a psychiatric outpatient who suffers from severe diabetes mellitus should be treated in the psychiatric ward. We examined 57 patients who were admitted to the psychiatric ward in the general hospital for the purpose of treating somatic complications. The patients had already suffered from mental disorders, and moreover, they were complicated by somatic illnesses. Somatic illnesses were relatively severe so that each somatic specialist cooperated with psychiatrists on treatment.
Mental disorders were schizophrenic disorder (N=30), mental retardation (N=8), dementia (N=6) and others. They were diagnosed by the criteria of DSM-Ⅲ. Of the 57 patients 46 were transferred from other institutions. Eleven were our out patients before admission. Among the purposes of admissions surgery was the most common (N=38). But in four cases operations were suspended after admission because of rejection by the patients (N=2) or the difficulties of postoperative management (N=2), Fifty patients were treated in the psychiatric ward throughout their admissions. Only seven cases were transferred to the "somatic" ward in the same hospital after admission to the psychiatric ward. Two patients died in the psychiatric ward.奈良医学会ArticleDepartmental Bulletin Paperapplication/pdf奈良医学雑誌 Vol.42 No.2 p.119-1230469555013450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/1990奈良医学雑誌, 42(2): 119-123http://hdl.handle.net/10564/1990http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/1990/1/119-123p%ef%bc%9a%e8%ba%ab%e4%bd%93%e8%a8%ba%e7%99%82%e7%a7%91%e5%85%b1%e8%a6%b3%e7%9b%ae%e7%9a%84%e3%81%a7%e7%b2%be%e7%a5%9e%e7%a7%91%e7%97%85%e6%a3%9f%e3%81%ab%e5%85%a5%e9%99%a2%e3%81%97%e3%81%9f%e7%b2%be%e7%a5%9e%e9%9a%9c%e5%ae%b3%e6%82%a3%e8%80%85%e3%81%ab%e3%81%a4%e3%81%84%e3%81%a6.pdf04695550AN00180974奈良医学雑誌4221191231991-04-30jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/19912017-05-29T06:07:53Zhdl_10564_1987糖尿病性腎症における運動負荷時の尿中シアル酸合有糖蛋白分子量パターンSDS-POLYACRYLAMIDE GEL ELECTROPHORESIS OF URINARY GLYCOPROTEINS AFTER EXERCISE IN PATIENTS WITH DIABETIC NEPHROPATHY西浦, 公章土肥, 和紘金内, 雅夫中島, 靖夫山野, 繁石川, 兵衞土肥, 祥子杉本, 和夫森山, 忠重diabetic nephropathyexercise testSDS-polyacrylamide gel electrophoresisurinary glycoproteinUrinary glycoprotein patterns after exercise were studied by electrophoresis in patients with diabetes mellitus for early diagnosis of diabetic nephropathy. The subjects were 21 patients with non-insulin dependent diabetes mellitus and 5 healthy volunteers. For each subject, voiding urine collection was done at rest and after a 20-minute exercise (300 Kpm/min). Urine samples were freeze-dried and subjected to electrophoresis (7.5% SDS-PAGE), followed by staining with PAS (sensitive to carbohydrate)
and CBB (sensitive to protein) for assay with a chromatoscanner. Urine samples were additionally assayed for albumin, sialic acid and acid-soluble protein. As for advanced diabetic nephropathy, many glycoproteins appeared in the urine at
rest. The molecular weights (MW) of the major glycoproteins detected in the urine at rest were 53,000 and 33,000. In healthy controls, urine collected after exercise contained no glycoproteins. However, in patients with incipient diabetic nephropathy, the MW 53,000 and 33,000 glycoproteins were present. Moreover, the levels of these two glycoproteins were higher than that of the urine at rest. In addition, postexercise urine from diabetics showed significantly elevated levels of sialic acid and acid-soluble protein. These results indicate that analysis of glycoprotein patterns in the urine at rest and after exercise is useful for the diagnosis of early diabetic nephropathy.奈良医学会ArticleDepartmental Bulletin Paperapplication/pdf奈良医学雑誌 Vol.42 No.2 p.124-1290469555013450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/1991奈良医学雑誌, 42(2): 124-129http://hdl.handle.net/10564/1991http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/1991/1/124-129p%ef%bc%9a%e7%b3%96%e5%b0%bf%e7%97%85%e6%80%a7%e8%85%8e%e7%97%87%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e9%81%8b%e5%8b%95%e8%b2%a0%e8%8d%b7%e6%99%82%e3%81%ae%e5%b0%bf%e4%b8%ad%e3%82%b7%e3%82%a2%e3%83%ab%e9%85%b8%e5%90%88%e6%9c%89%e7%b3%96%e8%9b%8b%e7%99%bd%e5%88%86%e5%ad%90%e9%87%8f%e3%83%91%e3%82%bf%e3%83%bc%e3%83%b3.pdf04695550AN00180974奈良医学雑誌4221241291991-04-30jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/19922017-05-29T06:07:53Zhdl_10564_1987Praziquantelによって駆虫しえた多数寄生の横川吸虫症の一例A CASE OF SEVERE METAGONIMIASIS YOKOGAWAI TREATED WITH PRAZIQUANTEL西山, 利正水野, 直人天野, 博之荒木, 恒治高谷, 章福井, 博辻井, 正Metagonimus yokogawaimetagonimiasis yokogawaipraziquantelMetagonimiasis yokogawai is one of the most common parasitic diseases affecting the gastrointestinal system in Japan. Most patients are usually asymptomatic and eggs from healthy carriers are found in stool. Infections of moderate to severe degree may
cause gastrointestinal signs and symptoms such as colic pain, weight loss, profuse mucus or occasional bloody diarrhea. This paper describes a severe case infected with Metagonimus yokogawai. A 41-year-old male who lived in Yoshino town, Nara Prefecture, complained of low abdominal pain, diarrhea and weight loss. He often eats sashimi (sliced raw fish) of Plecoglssus altivelis, the second intermediate host of M. yokogawai. He visited a nearby clinic because
of weight loss (-5 kg in 6 months) and severe diarrhea. Parasitic eggs were found in his stool, and he was referred to Nara Medical University. the eggs in the patient's stool were examined and the case was diagnosed as M. yokogawai infection. One day before treatment, his food intake was limited for the dose of examination of barium enema. On the day of treatment, he fasted except for water. he was treated with
a single administration of praziquantel (50 mg/kg). Three hours after treatment, he was
given magnesium sulfate (30 g) as a laxative in order to enhance defecation. More than 1,485 adult worms of M. yokogawai were found in this stool. In this case, side effects of
praziquantel were not observed. Three weeks after treatment, stool examinations did not reveal any parasite eggs in his stool and he recovered completely with this medication.奈良医学会ArticleDepartmental Bulletin Paperapplication/pdf奈良医学雑誌 Vol.42 No.2 p.130-1330469555013450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/1992奈良医学雑誌, 42(2): 130-133http://hdl.handle.net/10564/1992http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/1992/1/130-133p%ef%bc%9aPraziquantel%e3%81%ab%e3%82%88%e3%81%a3%e3%81%a6%e9%a7%86%e8%99%ab%e3%81%97%e3%81%88%e3%81%9f%e5%a4%9a%e6%95%b0%e5%af%84%e7%94%9f%e3%81%ae%e6%a8%aa%e5%b7%9d%e5%90%b8%e8%99%ab%e7%97%87%e3%81%ae%e4%b8%80%e4%be%8b.pdf04695550AN00180974奈良医学雑誌4221301331991-04-30jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/19932017-05-29T06:07:54Zhdl_10564_1987ラットの生体内で生成されたN-nitrosobis(2-hydroxypropyl)amineの発癌性に関する研究ENDOGENOUSLY SYNTHESIZED N-NITROSOBIS(2-HYDROXYPROPYL)AMINE AND ITS CARCINOGENIC POTENTIAL IN RATS山本, 一彦N-nitrosobis(2-hydroxypropyl)aminebis(2-hydroxyproryl)aminesodium nitriteendogenous nitrosationCarcinogenic activity of endogenously synthesized N-nitrosobis(2-hydroxypropyl)amine (BHP) from bis(2-hydroxypropyl)amine (BHPA) and tris(2-hydroxypropyl)amine (THPA) in the presence of sodium nitrite (SN) was investigated in male Wistar rats. The following results were obtained. 1) The synthesis of BHP from BHPA and THPA in the presence of SN was demonstrated in vitro and in vivo in the preliminary experiment and also confirmed by the urinary excretion of BHP in rats treated with 1% BHPA and 2% THPA in diet together with 0.3% SN in drinking water. 2) Tumors in nasal cavity and lung were induced in rats treated with 1% BHPA in diet together with 0.3% SN in drinking water for 94 weeks, the incidences of which reached
74% and 58%, respectively. However, no tumors were found in the target organs of
BHP in rats treated with 2% THPA in diet and 0.3% SN in drinking water for 102 weeks. 3) The initiation activity for liver by endogenously synthesized BHP was observed in rats treated with 1% BHPA in diet together with 0.15% and 0.3% SN in drinking water by
the quantitative analysis of glutathione S-transferase placental form (GST-P)-positive
foci but was not observed in rats treated with 2% THPA in diet together with 0.15% and 0.3% SN in drinking water. These results indicate that endogenously synthesized BHP has a carcinogenic activity similar to that of exogenously administered BHP, and that BHPA is more important as the precursor for endogenous BHP synthesis. Since the precursors of nitrosamines are widely distributed in the environment, endogenously
synthesized nitrosamines may play an important role in the development of human cancer.奈良医学会ArticleDepartmental Bulletin Paperapplication/pdf奈良医学雑誌 Vol.42 No.2 p.134-1520469555013450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/1993奈良医学雑誌, 42(2): 134-152http://hdl.handle.net/10564/1993http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/1993/1/134-152p%ef%bc%9a%e3%83%a9%e3%83%83%e3%83%88%e3%81%ae%e7%94%9f%e4%bd%93%e5%86%85%e3%81%a7%e7%94%9f%e6%88%90%e3%81%95%e3%82%8c%e3%81%9fN-nitrosobis%282-hydroxypropyl%29amine%e3%81%ae%e7%99%ba%e7%99%8c%e6%80%a7%e3%81%ab%e9%96%a2%e3%81%99%e3%82%8b%e7%a0%94%e7%a9%b6.pdf04695550AN00180974奈良医学雑誌4221341521991-04-30jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/19942017-05-29T06:07:55Zhdl_10564_1987パラインフルエンザ1型の抗体価の上昇を伴い特異な胸部X線所見を呈した器質化肺炎の1例A CASE OF ORGANIZING PNEUMONIA WITH ELEVATION OF ANTIBODY OF PARAINFLUENZA 1 VIRUS DURING THE COURSE友田, 恒一阿児, 博文濱田, 薫長, 澄人鴻池, 義純佐々木, 秀明成田, 亘啓organizing pneumoniaparainfluenza virusTBLBeosinophilic pneumoniaprednisolone therapyA case of organizing pneumonia is reported. A 74-year-old man was admitted to our hospital complaining of general fatigue and dyspnea of 2 months' duration. Chest roentogenogram on admission revealed interstitial shadow in the left upper-to-middle lung field. Thereafter the chest x-ray shadow showed migration to the left lower
lung and right middle lung fields, and superimposition with volume loss of the left lower lung. No pathogenic microorganisms were detected from sputum and throat swabs. No organisms were detected in the blood. Therefore he was set to conservative therapy alone. The antibody titer of parainfluenza virus type 1, initially 1:64, increased to 1:2048 just before bronchoscopy. The histopathological findings of TBLB showed that alveolar spaces were filled with organizing process and that septum was thickened slightly with edema and fibrosis, whose findings were compatible for organizing pneumonia. Prednisolone was begun and marked improvement of chest x-ray findings and clinical symptoms were achieved immediately. But recurrence was seen twice during withdrawal of steroids within six months and he died suddenly of unknown cause. Autopsy could not be performed. Although the pathogenesis of organizing pneumonia has not been determined yet, this case was of interest in two points : first, the chest x-ray finding was thought to be interstitial rather than alveolar process ; and second, antibody of parainfluenza virus type 1 fluctuated, suggesting some pathogenetic relation.奈良医学会ArticleDepartmental Bulletin Paperapplication/pdf奈良医学雑誌 Vol.42 No.2 p.153-1590469555013450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/1994奈良医学雑誌, 42(2): 153-159http://hdl.handle.net/10564/1994http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/1994/1/153-159p%ef%bc%9a%e3%83%91%e3%83%a9%e3%82%a4%e3%83%b3%e3%83%95%e3%83%ab%e3%82%a8%e3%83%b3%e3%82%b61%e5%9e%8b%e3%81%ae%e6%8a%97%e4%bd%93%e4%be%a1%e3%81%ae%e4%b8%8a%e6%98%87%e3%82%92%e4%bc%b4%e3%81%84%e7%89%b9%e7%95%b0%e3%81%aa%e8%83%b8%e9%83%a8X%e7%b7%9a%e6%89%80%e8%a6%8b%e3%82%92%e5%91%88%e3%81%97%e3%81%9f%e5%99%a8%e8%b3%aa%e5%8c%96%e8%82%ba%e7%82%8e%e3%81%ae1%e4%be%8b.pdf04695550AN00180974奈良医学雑誌4221531591991-04-30jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/19952017-05-29T06:07:55Zhdl_10564_198721-ハイドロキシラーゼ欠損症(塩喪失型)1家系における出生前診断の試みPRENATAL DIAGNOSIS IN A FAMILY WITH 21-HYDROXYLASE DEFICIENCY (SALT-WASTING TYPE)三上, 貞昭森井, 直之根津, 智子山下, 千賀子新家, 直子寺本, 好弘西村, 拓也中, 宏之21-hydroxylase deficiencyprenatal diagnosisDNA diagnosis17-OHPHLA haplotypeA prenatal diagnosis was performed in a family with salt-wasting type of 21-hydroxylase deficiency (21-OHD). A trial of DNA diagnosis in the family, including a
patient, did not reveal informative data when DNAs were restricted with TaqⅠ and hybridized with pC21/3c probe. The level of 17-OHP in the amnion was within a normal range. A girl was born without clinical symptoms. One HLA haplotype which was detected in the patient was inherited from the father. With a view to increasing the number of Japanese families which are proceeded to prenatal DNA diagnosis, it is expected that a beneficial combination with a small number of intragenic RFLPs and/or extragenic RFLPs close to the gene will be established and widely used. Hereafter, prenatal diagnosis in early pregnany will be important for families with 21-OHD.奈良医学会ArticleDepartmental Bulletin Paperapplication/pdf奈良医学雑誌 Vol.42 No.2 p.160-1640469555013450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/1995奈良医学雑誌, 42(2): 160-164http://hdl.handle.net/10564/1995http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/1995/1/160-164p%ef%bc%9a21-%e3%83%8f%e3%82%a4%e3%83%89%e3%83%ad%e3%82%ad%e3%82%b7%e3%83%a9%e3%83%bc%e3%82%bc%e6%ac%a0%e6%90%8d%e7%97%87%28%e5%a1%a9%e5%96%aa%e5%a4%b1%e5%9e%8b%291%e5%ae%b6%e7%b3%bb%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e5%87%ba%e7%94%9f%e5%89%8d%e8%a8%ba%e6%96%ad%e3%81%ae%e8%a9%a6%e3%81%bf.pdf04695550AN00180974奈良医学雑誌4221601641991-04-30jpnpublisher
oai:ginmu.naramed-u.ac.jp:10564/19962017-05-29T06:07:55Zhdl_10564_1987当科における過去8年間の顎顔面骨骨折の臨床統計的観察CLINICO-STATISTICAL STUDY OF MAXILLO-FACIAL FRACTURES FOR THE PAST 8 YEARS IN OUR CLINIC吉岡, 稔植村, 和嘉山本, 伸介吉田, 精司土田, 雅久板橋, 正憲藪内, 久江口, 陽子寺田, 貴子杉村, 正仁maxillo-facial fractureclinico-statistical analysisfacial multiple injuryClinico-statistical analysis was made in 537 patients with maxillo-facial fracture referred to the Department of Oral and Maxillo-facial Surgery, Nara Medical University Hospital, from October, 1981 to September, 1989. The following results were
obtained : 1. In an investigation of frequencies according to age, the two most common age groups were those in their teens and twenties. The ratio of males to females was 2.5:1. 2. Traffic accidents were the most frequent causes. Then falling and violence followed. About 70% of the patients came to our department within 7 days after injuries. 3. The common sites of the fractures were the mandible alone in 57.7% of cases, followed by zygomatic fracture. And 14 cases were found in the combined mandible, maxilla and zygoma. 4. Open reduction was applied to 48.9% of cases in mandibular fracture, and 41.6% in zygomatic fracture.奈良医学会ArticleDepartmental Bulletin Paperapplication/pdf奈良医学雑誌 Vol.42 No.2 p.165-1720469555013450069http://ginmu.naramed-u.ac.jp/dspace/handle/10564/1996奈良医学雑誌, 42(2): 165-172http://hdl.handle.net/10564/1996http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/1996/1/165-172p%ef%bc%9a%e5%bd%93%e7%a7%91%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e9%81%8e%e5%8e%bb8%e5%b9%b4%e9%96%93%e3%81%ae%e9%a1%8e%e9%a1%94%e9%9d%a2%e9%aa%a8%e9%aa%a8%e6%8a%98%e3%81%ae%e8%87%a8%e5%ba%8a%e7%b5%b1%e8%a8%88%e7%9a%84%e8%a6%b3%e5%af%9f.pdf04695550AN00180974奈良医学雑誌4221651721991-04-30jpnpublisher